DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tlr1 and Toll-7

DIOPT Version :9

Sequence 1:NP_001263374.1 Gene:Tlr1 / 21897 MGIID:1341295 Length:795 Species:Mus musculus
Sequence 2:NP_523797.1 Gene:Toll-7 / 37272 FlyBaseID:FBgn0034476 Length:1446 Species:Drosophila melanogaster


Alignment Length:777 Identity:168/777 - (21%)
Similarity:295/777 - (37%) Gaps:223/777 - (28%)


- Green bases have known domain annotations that are detailed below.


Mouse    35 PNANLTRVPKDLP--LQTTTLDLSQNNISELQTSDILSLSKLRVLIMSYNRLQYLNISVF----- 92
            |...|...|..|.  .|.|.|||..||:.:|.:..:..:..|:||.::.||::......|     
  Fly   174 PTRTLELFPDSLGGLKQLTDLDLGDNNLRQLPSGFLCPVGNLQVLNLTRNRIRTAEQMGFADMNC 238

Mouse    93 -----KFNTELEYLDLSHNELKVILCHPTVS----LKHLDLSFNAFDALPICKEFGNMSQLQFLG 148
                 ...:||:.||.|||||:.|.....:|    |:||:|::|....|. .:....::.|:.:.
  Fly   239 GAGSGSAGSELQVLDASHNELRSISESWGISRLRRLQHLNLAYNNLSELS-GEALAGLASLRIVN 302

Mouse   149 LSGSRVQSSSVQLIA--------HLNISKV-------------LLVLGDAYGEKEDPESLRHVST 192
            ||.:.:::....|.|        ||..:::             |||: |..|.:   .:..||..
  Fly   303 LSNNHLETLPEGLFAGSKELREIHLQQNELYELPKGLFHRLEQLLVV-DLSGNQ---LTSNHVDN 363

Mouse   193 ETL-----------------HIVFPSKREFRFLLDVSV-STTIG-------LELSNIKCV----- 227
            .|.                 .|.:.:.:|..||..::: :.:||       |.|.|:..:     
  Fly   364 TTFAGLIRLIVLNLAHNALTRIDYRTFKELYFLQILNLRNNSIGHIEDNAFLPLYNLHTLNLAEN 428

Mouse   228 ----LEDQGCSYFLRALSKLGKNL-KLSNLTLNNVETTWNSFINILQIVWHTPVKYFSISNVKLQ 287
                |:|           ||...| .||.|||||         |::.:|  .|..:.:.|::| :
  Fly   429 RLHTLDD-----------KLFNGLYVLSKLTLNN---------NLISVV--EPAVFKNCSDLK-E 470

Mouse   288 GQLAFRMFNYSDTSLKALSI--------HQVVTDVFSFPQSYIYSIFANMNIQNF-TMSGTHMVH 343
            ..|:....|....:|:.|::        :|:.|             |.|.:.:|. .::|..:: 
  Fly   471 LDLSSNQLNEVPRALQDLAMLRTLDLGENQIRT-------------FDNQSFKNLHQLTGLRLI- 521

Mouse   344 MLCPSQVSPFLHVDFTDNLLTDMVFKDCRNLVRLKTLSLQKNQLKNLENIILTSAKMTSLQKLDI 408
                            ||.:.::.....::|.||..|:|.||:::::|.  .:..|...|:.:.:
  Fly   522 ----------------DNQIGNITVGMFQDLPRLSVLNLAKNRIQSIER--GSFDKNFELEAIRL 568

Mouse   409 SQNSLRYSDGGIPCAWTQSLLVLNLSSNMLTGSVFRCLPPKVKVLDLHNNRIMSIPKDVTHLQAL 473
            .:|.|...:|..  |...|||.||||.|.|....:..:|..:|.||:|.|.|.::    .:...|
  Fly   569 DRNFLADINGVF--ATLVSLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEAL----GNYYKL 627

Mouse   474 QE------LNVASNSLTDLPGCGAFSSLSVLVIDHNSVSHPSEDFFQSCQNIRSLT--------- 523
            ||      |:.:.|.:|::......:::.:|.|::|.:.:...:.|....|:..:.         
  Fly   628 QEEIRVKTLDASHNRITEIGPMSIPNTIELLFINNNLIGNVQPNAFVDKANLARVDLYANQLSKL 692

Mouse   524 --------------------AGNNPFQCTCELRDFVKNIGWVAREVVEGWPD--SYRCDYPESSR 566
                                .|.|||:|.|.: |:::.|..:.........|  :..|..|. :|
  Fly   693 QLQQLRVAPVVAPKPLPEFYLGGNPFECDCTM-DWLQRINNLTTRQHPRVMDMANIECVMPH-AR 755

Mouse   567 GTALRDFHMSPLS--------------CDTVLLTVTIGATMLVLAVTGAFLCLYFDLPWYVRML- 616
            |.|:|     |||              |..:.......|....:.......| |.|..|...:: 
  Fly   756 GAAVR-----PLSGLRPQDFLCRYESHCFALCHCCDFDACDCEMTCPSNCTC-YHDQIWSTNVVD 814

Mouse   617 CQWTQTRHRARHIPLEE----LQRN----LQFHAFVS--------YSGHDSAWVKNELLPNL 662
            |...||....|.:|::.    |..|    |:.|||:.        .:|...|.::|....:|
  Fly   815 CGGQQTTELPRRVPMDSSVVYLDGNNFPVLKNHAFIGRKNLRALYVNGSQVAAIQNRTFASL 876

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tlr1NP_001263374.1 PRK15370 <38..>133 CDD:185268 33/110 (30%)
LRR <48..317 CDD:227223 78/346 (23%)
leucine-rich repeat 50..73 CDD:275378 7/22 (32%)
LRR 1 54..77 6/22 (27%)
leucine-rich repeat 74..97 CDD:275378 6/32 (19%)
LRR 2 78..101 5/32 (16%)
leucine-rich repeat 98..118 CDD:275378 9/19 (47%)
LRR 3 102..125 11/26 (42%)
leucine-rich repeat 119..143 CDD:275378 6/23 (26%)
LRR 4 126..150 3/23 (13%)
leucine-rich repeat 144..156 CDD:275378 3/11 (27%)
LRR 5 151..175 7/44 (16%)
LRR 6 176..199 6/39 (15%)
LRR 7 200..223 7/30 (23%)
LRR 8 224..250 5/35 (14%)
LRR 9 251..278 8/26 (31%)
LRR 10 279..308 6/36 (17%)
LRR 11 309..337 5/28 (18%)
Interaction with bacterial lipopeptide. /evidence=ECO:0000250 316..319 0/2 (0%)
LRR 12 338..361 1/22 (5%)
leucine-rich repeat 355..376 CDD:275380 3/20 (15%)
LRR 13 362..388 7/25 (28%)
PRK15370 <377..>487 CDD:185268 34/115 (30%)
leucine-rich repeat 377..402 CDD:275380 7/24 (29%)
LRR 14 389..414 4/24 (17%)
leucine-rich repeat 403..427 CDD:275380 5/23 (22%)
LRR 15 415..437 9/21 (43%)
leucine-rich repeat 428..449 CDD:275380 9/20 (45%)
LRR 16 438..457 5/18 (28%)
leucine-rich repeat 450..472 CDD:275380 6/21 (29%)
LRR 17 458..478 6/25 (24%)
leucine-rich repeat 473..494 CDD:275380 6/26 (23%)
LRR 18 479..500 3/20 (15%)
leucine-rich repeat 495..518 CDD:275380 4/22 (18%)
LRR 19 501..524 3/51 (6%)
LRRCT 527..581 CDD:214507 17/69 (25%)
TIR 639..782 CDD:214587 7/32 (22%)
Toll-7NP_523797.1 LRR_8 135..201 CDD:290566 10/26 (38%)
leucine-rich repeat 136..159 CDD:275380
leucine-rich repeat 160..190 CDD:275380 4/15 (27%)
LRR_8 189..259 CDD:290566 21/69 (30%)
leucine-rich repeat 191..214 CDD:275380 7/22 (32%)
leucine-rich repeat 215..248 CDD:275380 6/32 (19%)
LRR_RI 247..501 CDD:238064 62/281 (22%)
LRR_8 247..308 CDD:290566 20/61 (33%)
leucine-rich repeat 249..273 CDD:275380 10/23 (43%)
leucine-rich repeat 274..297 CDD:275380 6/23 (26%)
LRR_8 297..356 CDD:290566 12/62 (19%)
leucine-rich repeat 298..321 CDD:275380 5/22 (23%)
leucine-rich repeat 322..345 CDD:275380 2/22 (9%)
LRR_8 345..406 CDD:290566 12/64 (19%)
leucine-rich repeat 346..371 CDD:275380 8/28 (29%)
leucine-rich repeat 372..395 CDD:275380 2/22 (9%)
leucine-rich repeat 396..419 CDD:275380 5/22 (23%)
LRR_8 419..478 CDD:290566 19/81 (23%)
leucine-rich repeat 420..443 CDD:275380 5/33 (15%)
leucine-rich repeat 444..467 CDD:275380 10/33 (30%)
LRR_RI 466..622 CDD:238064 44/194 (23%)
leucine-rich repeat 468..488 CDD:275380 4/20 (20%)
LRR_8 491..549 CDD:290566 15/87 (17%)
leucine-rich repeat 491..514 CDD:275380 5/35 (14%)
leucine-rich repeat 515..536 CDD:275380 3/37 (8%)
leucine-rich repeat 539..562 CDD:275380 7/24 (29%)
leucine-rich repeat 563..585 CDD:275380 5/23 (22%)
leucine-rich repeat 586..626 CDD:275380 15/43 (35%)
leucine-rich repeat 627..653 CDD:275380 6/25 (24%)
LRRCT 716..772 CDD:214507 17/62 (27%)
LRRNT 796..830 CDD:214470 9/34 (26%)
leucine-rich repeat 812..829 CDD:275380 4/16 (25%)
leucine-rich repeat 833..854 CDD:275380 6/20 (30%)
LRR_8 853..913 CDD:290566 4/24 (17%)
leucine-rich repeat 855..878 CDD:275380 4/22 (18%)
LRR_4 878..918 CDD:289563
leucine-rich repeat 879..902 CDD:275380
leucine-rich repeat 903..926 CDD:275380
leucine-rich repeat 927..953 CDD:275380
TIR 1098..1235 CDD:214587
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X221
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.820

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