DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tll1 and tld

DIOPT Version :9

Sequence 1:	NP_033416.2	Gene:	Tll1 / 21892	MGIID:	106923	Length:	1013	Species:	Mus musculus
Sequence 2:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster

Alignment Length:	964	Identity:	426/964 - (44%)
Similarity:	590/964 - (61%)	Gaps:	60/964 - (6%)

- Green bases have known domain annotations that are detailed below.

Mouse   102 PKK-RGALYQLIERIRRIGSGLEQNNTMKGKA-----PPKL-----------SEQSEKNRVP--- 146
            ||: :..:|||....:..|...:|::..:.||     ||.|           |.....|..|
  Fly    69 PKEPKDDIYQLKTTRQHSGRRRKQSHKSQNKAALRLPPPFLWTDDAVDVLQHSHSPTLNGQPIQR 133

Mouse   147 --RAATSRTERIWPGGVIPYVIGGNFTGSQRAMFKQAMRHWEKHTCVTFTERSD--EESYIVFTY 207
              ||.|.|.||.|..|||||.|...|:|:.:|:|||||||||..||:.|.||..  ..:||.||.
  Fly   134 RRRAVTVRKERTWDYGVIPYEIDTIFSGAHKALFKQAMRHWENFTCIKFVERDPNLHANYIYFTV 198

Mouse   208 RPCGCCSYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDNHVTIIRENIQPGQ 272
            :.|||||::|:.|||.|.||||:||:||||::|||||.|||.|||.|.|||.|:.|.:.||..||
  Fly   199 KNCGCCSFLGKNGNGRQPISIGRNCEKFGIIIHELGHTIGFHHEHARGDRDKHIVINKGNIMRGQ 263

Mouse   273 EYNFLKMEPGEVNSLGERYDFDSIMHYARNTFSRGMFLDTILPSRDDNGIRPAIGQRTRLSKGDI 337
            ||||..:.|.||:.....||.:||||||:|:||:..:||||.|.....|....:|||.|||:|||
  Fly   264 EYNFDVLSPEEVDLPLLPYDLNSIMHYAKNSFSKSPYLDTITPIGIPPGTHLELGQRKRLSRGDI 328

Mouse   338 AQARKLYRCPACGETLQESSGNLSSPGF---PNGY---------------------PSYTHCIWR 378
            .||..||:|.:||.|.|::||::.||.|   .||.                     .|.|:|.||
  Fly   329 VQANLLYKCASCGRTYQQNSGHIVSPHFIYSGNGVLSEFEGSGDAGEDPSAESEFDASLTNCEWR 393

Mouse   379 VSVTPGEKIVLNFTTMDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCGDKVAGVLTSTDSRMWIEF 443
            ::.|.|||::|:...:.|..|..|..||:|:|||||.||||:.|.||:....|:|:..|||.:.:
  Fly   394 ITATNGEKVILHLQQLHLMSSDDCTQDYLEIRDGYWHKSPLVRRICGNVSGEVITTQTSRMLLNY 458

Mouse   444 RSSSNWVG-KGFAAVYEAICGGEIRKNEGQ-IQSPNYPDDYRPMKECVWKIMVSEGYHVGLTFQA 506
            .:.:...| :||.|.:|.:|||:::..:.| |.|||||.||.|.|||||:|...:.:.|.|.||:
  Fly   459 VNRNAAKGYRGFKARFEVVCGGDLKLTKDQSIDSPNYPMDYMPDKECVWRITAPDNHQVALKFQS 523

Mouse   507 FEIERHDSCAYDHLEVRDGASENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANF 571
            ||:|:||.||||.:|:|||...:|.|||||||...|.:|::.||.::::||||.:|.|.||:|..
  Fly   524 FELEKHDGCAYDFVEIRDGNHSDSRLIGRFCGDKLPPNIKTRSNQMYIRFVSDSSVQKLGFSAAL 588

Mouse   572 FKEEDECAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLL--TKLNGTITTPGW 634
            ..:.|||...|. ||:..|:||||||||.|..||||..:.::||.||||::  ||.||::.:|.:
  Fly   589 MLDVDECKFTDH-GCQHLCINTLGSYQCGCRAGYELQANGKTCEDACGGVVDATKSNGSLYSPSY 652

Mouse   635 PKEYPPNKNCVWQVIAPSQYRISVKFEFFELEGNEV----CKYDYVEIWSGL-SSESKLHGKFCG 694
            |..||.:|.|||:|:||..:.:.:.|..|:|||...    |.|||:.|:|.: .:..|..|.:||
  Fly   653 PDVYPNSKQCVWEVVAPPNHAVFLNFSHFDLEGTRFHYTKCNYDYLIIYSKMRDNRLKKIGIYCG 717

Mouse   695 ADIPEVMTSHFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTMGSYTCQCRNG 759
            .::|.|:.|..:.:|:||.||.||.:.||.|.|..|.||||.:||||||.|.||.|||.|.||||
  Fly   718 HELPPVVNSEQSILRLEFYSDRTVQRSGFVAKFVIDVDECSMNNGGCQHRCRNTFGSYQCSCRNG 782

Mouse   760 FVLHENKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWVISAIPGHRITLAFNEFEVEQH 824
            :.|.||.|:|.|..|:.:|.:..|::.|||:|:.||....|.|....:.||||.|.|::||||.|
  Fly   783 YTLAENGHNCTETRCKFEITTSYGVLQSPNYPEDYPRNIYCYWHFQTVLGHRIQLTFHDFEVESH 847

Mouse   825 QECAYDHLEIFDGETEKSPILGRLCGSKIPDPLMATGNEMFIRFISDASVQRKGFQATHSTECGG 889
            |||.||::.|:||.:|.|..||..||.:.|..::|:.||||:...:||.:|||||:||..:||||
  Fly   848 QECIYDYVAIYDGRSENSSTLGIYCGGREPYAVIASTNEMFMVLATDAGLQRKGFKATFVSECGG 912

Mouse   890 RLKAESKPRDLYSHAQFGDNNYPGQLDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVEVF-D 953
            .|:|.:..:..|||.::|...|...:.|:|.:.::..|.:::.|..||:|....|.|||:|:. :
  Fly   913 YLRATNHSQTFYSHPRYGSRPYKRNMYCDWRIQADPESSVKIRFLHFEIEYSERCDYDYLEITEE 977

Mouse   954 GLSSKAVGLGRFCGSGPPEEIYSIGDVALIHFHTDDTINKKGFYIRYKSIRYPE 1007
            |.|...:. |||||...|..|.|..|..|:.|.||::.:.:||.|.:.::..||
  Fly   978 GYSMNTIH-GRFCGKHKPPIIISNSDTLLLRFQTDESNSLRGFAISFMAVDPPE 1030

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tll1	NP_033416.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	124..150		11/46 (24%)
		ZnMc_BMP1_TLD	148..347	CDD:239808	111/200 (56%)
		Astacin	155..348	CDD:279708	108/194 (56%)
		CUB	349..458	CDD:278839	48/133 (36%)
		CUB	462..571	CDD:278839	57/109 (52%)
		FXa_inhibition	582..614	CDD:291342	17/31 (55%)
		CUB	618..727	CDD:278839	46/115 (40%)
		FXa_inhibition	734..769	CDD:291342	23/34 (68%)
		CUB	774..883	CDD:278839	50/108 (46%)
		CUB	887..1000	CDD:278839	40/113 (35%)
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	111/200 (56%)
		Astacin	144..339	CDD:279708	108/194 (56%)
		CUB	388..474	CDD:214483	36/85 (42%)
		CUB	478..586	CDD:278839	56/107 (52%)
		FXa_inhibition	595..630	CDD:291342	18/35 (51%)
		CUB	634..750	CDD:278839	46/115 (40%)
		FXa_inhibition	757..792	CDD:291342	23/34 (68%)
		CUB	797..906	CDD:278839	50/108 (46%)
		CUB	910..1023	CDD:278839	40/113 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849595
Domainoid	1	1.000	286	1.000	Domainoid score	I1591
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1014	1.000	Inparanoid score	I286
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48714
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001707
OrthoInspector	1	1.000	-	-		mtm8692
orthoMCL	1	0.900	-	-		OOG6_101061
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1101
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.800