DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tll1 and Cubn

DIOPT Version :9

Sequence 1:NP_033416.2 Gene:Tll1 / 21892 MGIID:106923 Length:1013 Species:Mus musculus
Sequence 2:NP_727348.2 Gene:Cubn / 326235 FlyBaseID:FBgn0052702 Length:3750 Species:Drosophila melanogaster


Alignment Length:836 Identity:204/836 - (24%)
Similarity:335/836 - (40%) Gaps:209/836 - (25%)


- Green bases have known domain annotations that are detailed below.


Mouse   301 RNTFSRGMFLDTILPSRDDNGIRPAIGQRTRLSKGDIAQARKLYRCPACGETLQESSGNLSSPGF 365
            |.|.|..:|:...||           |.|.||.:         .|..:|...|...||.|..|..
  Fly   481 RPTTSGDLFVCQCLP-----------GYRGRLCE
---------TRFSSCNGMLSAQSGRLRYPPE 525

Mouse   366 PNGYPSYTHCIWRVSVTPGEKIVLN--FTTMDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCGDKV 428
            ..||.....|.|  .:...|.:|:|  |.:.|:..|:.|.:|::::.||....:.::||:||:.:
  Fly   526 GTGYEHNAQCAW--VIRTNESLVVNVTFNSFDVEDSTECRFDWLQINDGRSAAAQIIGRYCGNHL 588

Mouse   429 --AGVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAI---CGGEIR-KNEGQIQSPNYPDDYRPMKE 487
              .|.:.|:.:::::.|||.::...:||...:.::   |||.:. :..|.:.||..|.:|...::
  Fly   589 PHGGNIVSSGNQLYLWFRSDNSTAKEGFDLTWNS
MEPQCGGRLNFETHGTLASPGSPGNYPKNRD 653

Mouse   488 CVWKIMVSEGYHVGLTFQAFEIERHDSCAYDHLEVRDGASENSPLIGRFCGYDKPEDIRSTSNTL 552
            |.|:::......:.|||.:.::|:|.:|.:|::.::|..|...  :.::|....|..:...::..
  Fly   654 CRWQLVAPTTKRIKLTFFSLQLEQHANCNFDYVLIKDSISGRE--LAKYCTTGAPAPLLLPTHLA 716

Mouse   553 WMKFVSDGTVNKAGFAANFFKEEDECAKPDRGGCEQRCLNTLGSYQCA-CEPG-----YE----- 606
            .:.|.||...:..||..::..||   ..|..||.......|:.....| .|||     ||     
  Fly   717 EIHFHSDAEGSDTGFQLHYSV
EE---RVPGCGGVYTAKEGTISESSTANTEPGGVSCEYEIHLAV 778

Mouse   607 ----------LGPDRRSC---------------EAACGGLLTKLN-------------------- 626
                      |..|...|               |..||...::||                    
  Fly   779 GEQVVIQFARLELDPLDCLEVLDITDEGGSILQEKICGSDASRLNPPTFTSEFNRLKIKFYARAG 843

Mouse   627 ------------------GTITTPGWPKEYPPNKNCVWQVIAPSQYRISVKFEFFEL-------E 666
                              ||||:||:|.....::.|.:.:...:...||:|...|:|       :
  Fly   844 SFQLNYRMACDYKLNNEQGTITSPGYPNLTRSDRICTYTISTATNTVISLKRIDFQLTNGESDDD 908

Mouse   667 GNEVCKYDYVEIWSGLSSESKLHGKFCGADIPEV-MTSHFNNMRIEFKSDNTVSKKGFKAHF--- 727
            .|:.|....:.|..||:  .|:.|.:||.:.||. ..|..|.:::...:|.....:|||..:   
  Fly   909 DNDECLTTNLRINDGLN--RKILGPYCGKNQPEENFVSETNYLQLHLSTDVDSMGRGFKFEYRAL 971

Mouse   728 FSDKDECSKDNGGCQHECVNTMGSYTCQCRNGFVLHENKHDCKEAECEQKIHSPSG-LITSPNWP 791
            .:..|:|    ||                                     :|:.|| .|..|...
  Fly   972 ATGNDKC----GG-------------------------------------VHTRSGDHIRLPVHD 995

Mouse   792 DKYPSRKECTWVISAIPGHRITLAFNEFEVEQHQECAYDHLEIFDG-----ETEKSPILGRLCGS 851
            |.|.....|.|||.|.....|.|.:|.|.:|...:|.||:|||:|.     ..|:|..|.:.||:
  Fly   996 DSYAGEATCYWVIMAPANKAIRLHWNSFSLENAVDCIYDYLEIYDSLGAQVNDERSKPLAKYCGN 1060

Mouse   852 KIPDPLMATGNEMFIRFISDASVQRKGFQATHSTE----CGGRLKAESKPRDLYSHAQFGD---- 908
            .:|:.|::...::.::|:||.|....||..|::.|    |||.:           ||..|:    
  Fly  1061 SVPEDLLSHSRQLVLKFVSDYSESDGGFDLTYTFEDRAKCGGHI-----------HASSGELTSP 1114

Mouse   909 ---NNYPGQLDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVEVFDGLSSKAVGLGRFCGSGP 970
               .||...|||:|.|.......||:..:.||:|:..:|..||:||.:|..:.:..:|||||...
  Fly  1115 EYPANYSAGLDCDWHLTGTIDHLLEIQVENFELEQSPNCSADYLEVRNGGGTDSPLIGRFCGRDI 1179

Mouse   971 PEEIYSIGDVALIHFHTDDTINKKGFYIRYK------------------SIRYPET 1008
            |..|........:..|||..||.:||.:|::                  |.|||.:
  Fly  1180 PARIPGFSHEMRLILHTDSAINGRGFRLRWRIFAFGCGGSLRSNMGAISSPRYPNS 1235

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tll1NP_033416.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 124..150
ZnMc_BMP1_TLD 148..347 CDD:239808 11/45 (24%)
Astacin 155..348 CDD:279708 11/46 (24%)
CUB 349..458 CDD:278839 31/112 (28%)
CUB 462..571 CDD:278839 26/109 (24%)
FXa_inhibition 582..614 CDD:291342 11/52 (21%)
CUB 618..727 CDD:278839 34/154 (22%)
FXa_inhibition 734..769 CDD:291342 3/34 (9%)
CUB 774..883 CDD:278839 37/114 (32%)
CUB 887..1000 CDD:278839 38/119 (32%)
CubnNP_727348.2 EGF_CA 156..190 CDD:238011
EGF_CA 192..233 CDD:238011
EGF_CA 282..322 CDD:214542
EGF_3 328..366 CDD:289699
EGF 430..457 CDD:278437
EGF_CA 469..503 CDD:238011 10/32 (31%)
CUB 509..622 CDD:238001 31/114 (27%)
CUB 627..737 CDD:238001 26/111 (23%)
CUB 744..849 CDD:294042 17/104 (16%)
CUB 853..970 CDD:238001 30/118 (25%)
CUB 978..1094 CDD:238001 41/156 (26%)
CUB 1100..1211 CDD:238001 39/121 (32%)
CUB 1216..1330 CDD:238001 4/20 (20%)
CUB 1446..1549 CDD:238001
CUB 1554..1667 CDD:238001
CUB 1792..1899 CDD:238001
CUB 1910..1998 CDD:294042
CUB 2019..2133 CDD:238001
CUB 2140..2242 CDD:238001
CUB 2263..2379 CDD:238001
CUB 2385..2511 CDD:238001
CUB 2516..2630 CDD:238001
CUB <2833..2892 CDD:294042
CUB 2898..3008 CDD:238001
CUB 3011..3127 CDD:238001
CUB 3130..3241 CDD:238001
CUB 3254..3363 CDD:238001
CUB 3379..3508 CDD:238001
CUB 3531..3601 CDD:294042
CUB 3623..3733 CDD:238001
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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