DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tjp2 and pyd

DIOPT Version :9

Sequence 1:	XP_006526967.1	Gene:	Tjp2 / 21873	MGIID:	1341872	Length:	1208	Species:	Mus musculus
Sequence 2:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster

Alignment Length:	1361	Identity:	401/1361 - (29%)
Similarity:	602/1361 - (44%)	Gaps:	371/1361 - (27%)

- Green bases have known domain annotations that are detailed below.

Mouse     4 GRRKGKEEKMPVFR-RSTNSLSSGPGKKQALRTTGKGPGMEEVIWEQYTVTLQKDSKRGFGIAVS 67
            |:|.|.:....:.. .||:|.|.....|:..|||          ||.:||.:.:....|||||||
  Fly   212 GKRDGGDNNSNLLETASTHSSSQRRRFKKGDRTT----------WEYHTVAVTRVPGYGFGIAVS 266

Mouse    68 GGRDNPHFENGETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKIAAI 132
            ||||||||.||:.||.:||||.||||:..||.|||::.|||..:|:|.::.|||.||.||....:
  Fly   267 GGRDNPHFANGDPSIAVSDVLKGGPAEDRLQVNDRIISVNGVSLENVEYATAVQVLRDSGNTVQL 331

Mouse   133 VVKRPRKVQVAPLQGSPPLSHDDRGFEVIEEFDGRSFRSGYSERSRHSSHDMLSHSWEGNRERGR 197
            |||  |:|.:.|:..:..:.|                        :| ||.:.|.....|.
  Fly   332 VVK--RRVPLNPINAAGAVQH------------------------QH-SHSLSSVGLMANG---- 365

Mouse   198 PHQRTQSRERERSRGRSLERGLDQEDYGRSRERSRGRSLERGLDRDFVSRDHSRGRSIDRDYDRD 262

  Fly   366 ----------------------------------------------------------------- 365

Mouse   263 YERSYHEAYEPDYGGGYSPSYDRRAHPETRYERSRSREHLRSRSPSPESRSRHEHKGQHDPDRPI 327
                         .||.:|:      |.|...:..|   |.|      |..::...||     ||
  Fly   366 -------------SGGVAPT------PITSLSQPNS---LNS------SLVQNASSGQ-----PI 397

Mouse   328 GVLLTKSKANEEYGLRLGSQIFIKEMT---RTGLATKDGNLHEGDIILKINGT-VTENMSLTDAR 388
            .|.|||....::||:.||.::|:||::   |..|.....:|.|||||.:|:.| ..:.|||.:|:
  Fly   398 KVTLTKGGKKDDYGVVLGCRLFVKEISSKAREQLNANGYSLQEGDIITRIHNTNCGDTMSLKEAK 462

Mouse   389 KLIEKSRGKLQLVVLRD-SKQTLINIPALNDSDS-------------EVEDISEIESNRSFSPEE 439
            |:|:..:.:|.|||||| :.||.::...||:|.|             :|...|...:|.......
  Fly   463 KIIDGCKERLNLVVLRDITNQTAVSQLNLNNSASHQASGNIYATHQPQVSGCSSSNNNLEDPYLP 527

Mouse   440 RRQQYSDQDYH-----------------SSTEKLKERPSSREE------------------TSGR 469
            ....||.|:.:                 .:.||....|..|..                  |.||
  Fly   528 GGASYSSQNLYVQPPTRTSNGPNINGNGLNDEKSNLTPRGRSRGPIMDGVSLQQLDRPVTPTRGR 592

Mouse   470 LSRMGATPTPFKSTGDITAAGVTE--ASREPRYQEEGPVPQPRTAPRVFLRPSPEDEAIYGPNTK 532
            .:.:...|.|....|....|...:  :||...|:|               |.|.|        .:
  Fly   593 SAAIDEPPRPPPPRGSSGGAAQEDFYSSRRQLYEE---------------RQSAE--------PR 634

Mouse   533 MVRFKKGDSVGLRLAGGNDVGIFVAGIQEGTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLL 597
            .:.|:|..|||:||.|||:.||||..:|.|:.|..:||..||:|||||..|..|:.||:|||:||
  Fly   635 FISFQKEGSVGIRLTGGNEAGIFVTAVQPGSPASLQGLMPGDKILKVNDMDMNGVTREEAVLFLL 699

Mouse   598 EIPKGETVTILAQSRADVYRDILACGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGK 662
            .:.  :.:.::.|...:.|.:::...|||||.|::||.|:..:...:||..|:||||:|||::|.
  Fly   700 SLQ--DRIDLIVQYCKEEYDEVVTNQRGDSFHIKTHFHCDNPSKGEMAFKAGDVFRVIDTLHNGV 762

Mouse   663 LGHWLAVRIG---NELEKGLIPNKSRAEQMASVQ-NAQRE--NAGD-RADFWRMRGQRSSGGVKK 720
            :|.|..::||   .|:::|:||||||||::|:.| ||.::  ||.: |.:|:|.|  ||:....|
  Fly   763 VGSWQVLKIGRGHQEMQRGVIPNKSRAEELATAQFNATKKEMNANESRGNFFRRR--RSTHRRSK 825

Mouse   721 NL-RKSREDLAAAVSVSTKFPAYEKVLLREAGFKRPVVLFGPIADIAMERLATELPDLFQT-AKT 783
            :| |::.:|:..:.|:| ||||||:|:||..||.||||||||::|:|.||||.:.||.|.| .:.
  Fly   826 SLSRENWDDVVFSDSIS-KFPAYERVVLRHPGFVRPVVLFGPVSDLARERLAKDFPDKFSTPLQD 889

Mouse   784 EPKDAGSEKSSGVVRLNTVRQIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTIR 848
            :.|.|.:.....:|||:.:|.::::.||||||:||.|||.|||.|::|:|||...||:..:|.:|
  Fly   890 DDKSAATSGKCRIVRLSNIRDVMDRGKHALLDITPNAVDRLNYAQFYPVVIFLKTDSKHVIKQLR 954

Mouse   849 QRLSPTSNKSSRKLFDQANKLKKTCSHLFTATINVNSANDGWFGSLKDSIQQQQNEAVWVSEGK- 912
            ..|...::|||:||.:|..||::..||:|:..|.: |..:.|:..|:|||..||:.|||:||.|
  Fly   955 HGLPKAAHKSSKKLLEQCQKLERVWSHIFSTQIAL-SDEESWYRKLRDSIDLQQSGAVWMSESKP 1018

Mouse   913 MEGMDDDAEDRMSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELEEPAEEPLVSSITRSSE 977
            :|.:.||      :|..|....||..|...||.|.:.|...:.:...|.:     ||.:   ||:
  Fly  1019 VESLSDD------FLFPMTTSRLSYASSPESDLELSPGPSASLSLGNLPQ-----LVKA---SSD 1069

Mouse   978 P--VQHEENIRKSSPEPRAQMRRAASRDQLRDASPPPAFKP-EPPKARSQNREDSFDYSKSNLPA 1039
            |  ..:::|:.:             .||.:.:..|||...| :.....:.||..:.|.||.::
  Fly  1070 PSIATNQDNLDR-------------DRDIIGEGLPPPYTVPYDHAVPANPNRRQTMDSSKYSI-- 1119

Mouse  1040 TAGSEIP--------GGSTKGYPPPIAAKPAFG--RPILKP-----STPVPMP--------ESEE 1081
             .|:.:|        ||.|....|    :..:|  .|.|.|     |.|..:|        .:..
  Fly  1120 -YGTNVPPQQQQPGVGGDTAAVRP----QSLYGINAPDLPPRIDRQSKPGDIPLNTSGSSSRNGT 1179

Mouse  1082 VGESTEE--------QEDAPRSVLGRVKIF-----EKMDHKAKLQRMQ----ELQEAQNARI--- 1126
            :|.|.:|        |:|.....:.|..:.     |.:|.:.:.|:..    |.|...||::
  Fly  1180 LGRSAQERLFGKAVVQDDVQAEYITRNALVGSGAAETLDRQQQQQQQTHASLERQARLNAQLKAN 1244

Mouse  1127 ------------------------EIAQKH---------PDIYAVPIKAPKPDAGLPP----HMS 1154
                                    ::|.::         .|:.:||....:|   |||    |..
  Fly  1245 GVGAGGGGASTYDSVSSYDSYNNTQMAMQNLGRLGPNAPDDLKSVPNANGRP---LPPTGQSHEY 1306

Mouse  1155 SRPPEP------------QKAPSR-LYQDTRGSYGSDPEEEEYRQQLAAHSKRGYYSQPSR 1202
            .|.|..            |.:|.| .|.|...|...||.....::.    |..|..|.|.:
  Fly  1307 GRTPHDHRSFGGPNDLNRQSSPGRPHYHDMNASRNIDPRNGTPQRP----SNLGLESSPRK 1363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tjp2	XP_006526967.1	PDZ_signaling	50..135	CDD:238492	47/84 (56%)
		PDZ	329..406	CDD:214570	34/81 (42%)
		PDZ_signaling	531..608	CDD:238492	35/76 (46%)
		SH3_ZO-2	625..687	CDD:212960	31/64 (48%)
		GuKc	723..902	CDD:214504	81/179 (45%)
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492	47/84 (56%)
		PDZ_signaling	396..477	CDD:238492	32/80 (40%)
		PDZ_signaling	633..710	CDD:238492	35/78 (45%)
		SH3_ZO	729..790	CDD:212793	27/60 (45%)
		GuKc	831..1007	CDD:214504	80/177 (45%)
		ZU5	2263..2351	CDD:279170
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845443
Domainoid	1	1.000	113	1.000	Domainoid score	I6130
eggNOG	1	0.900	-	-		E1_KOG3580
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1175136at2759
OrthoFinder	1	1.000	-	-		FOG0001438
OrthoInspector	1	1.000	-	-		otm42386
orthoMCL	1	0.900	-	-		OOG6_103390
Panther	1	1.100	-	-	O	PTHR13865
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3326
SonicParanoid	1	1.000	-	-		X1692
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.740