Protein Alignment Tjp2 and pyd

DIOPT Version :10

• Sequence 1: XP_006526967.1
• Gene: Tjp2 / 21873
• MGIID: 1341872
• Length: 1208
• Species: Mus musculus
• Sequence 2: NP_001246998.1
• Gene: pyd / 41062
• FlyBaseID: FBgn0262614
• Length: 2395
• Species: Drosophila melanogaster
• Alignment Length: 1361
• Identity: 401/1361 - (29%)
• Similarity: 602/1361 - (44%)
• Gaps: 371/1361 - (27%)

Mouse     4 GRRKGKEEKMPVFR-RSTNSLSSGPGKKQALRTTGKGPGMEEVIWEQYTVTLQKDSKRGFGIAVS 67
            |:|.|.:....:.. .||:|.|.....|:..|||          ||.:||.:.:....|||||||
  Fly   212 GKRDGGDNNSNLLETASTHSSSQRRRFKKGDRTT----------WEYHTVAVTRVPGYGFGIAVS 266

Mouse    68 GGRDNPHFENGETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKIAAI 132
            ||||||||.||:.||.:||||.||||:..||.|||::.|||..:|:|.::.|||.||.||....:
  Fly   267 GGRDNPHFANGDPSIAVSDVLKGGPAEDRLQVNDRIISVNGVSLENVEYATAVQVLRDSGNTVQL 331

Mouse   133 VVKRPRKVQVAPLQGSPPLSHDDRGFEVIEEFDGRSFRSGYSERSRHSSHDMLSHSWEGNRERGR 197
            |||  |:|.:.|:..:..:.|                        :| ||.:.|.....|.
  Fly   332 VVK--RRVPLNPINAAGAVQH------------------------QH-SHSLSSVGLMANG---- 365

Mouse   198 PHQRTQSRERERSRGRSLERGLDQEDYGRSRERSRGRSLERGLDRDFVSRDHSRGRSIDRDYDRD 262
                                                                             
  Fly   366 ----------------------------------------------------------------- 365

Mouse   263 YERSYHEAYEPDYGGGYSPSYDRRAHPETRYERSRSREHLRSRSPSPESRSRHEHKGQHDPDRPI 327
                         .||.:|:      |.|...:..|   |.|      |..::...||     ||
  Fly   366 -------------SGGVAPT------PITSLSQPNS---LNS------SLVQNASSGQ-----PI 397

Mouse   328 GVLLTKSKANEEYGLRLGSQIFIKEMT---RTGLATKDGNLHEGDIILKINGT-VTENMSLTDAR 388
            .|.|||....::||:.||.::|:||::   |..|.....:|.|||||.:|:.| ..:.|||.:|:
  Fly   398 KVTLTKGGKKDDYGVVLGCRLFVKEISSKAREQLNANGYSLQEGDIITRIHNTNCGDTMSLKEAK 462

Mouse   389 KLIEKSRGKLQLVVLRD-SKQTLINIPALNDSDS-------------EVEDISEIESNRSFSPEE 439
            |:|:..:.:|.|||||| :.||.::...||:|.|             :|...|...:|.......
  Fly   463 KIIDGCKERLNLVVLRDITNQTAVSQLNLNNSASHQASGNIYATHQPQVSGCSSSNNNLEDPYLP 527

Mouse   440 RRQQYSDQDYH-----------------SSTEKLKERPSSREE------------------TSGR 469
            ....||.|:.:                 .:.||....|..|..                  |.||
  Fly   528 GGASYSSQNLYVQPPTRTSNGPNINGNGLNDEKSNLTPRGRSRGPIMDGVSLQQLDRPVTPTRGR 592

Mouse   470 LSRMGATPTPFKSTGDITAAGVTE--ASREPRYQEEGPVPQPRTAPRVFLRPSPEDEAIYGPNTK 532
            .:.:...|.|....|....|...:  :||...|:|               |.|.|        .:
  Fly   593 SAAIDEPPRPPPPRGSSGGAAQEDFYSSRRQLYEE---------------RQSAE--------PR 634

Mouse   533 MVRFKKGDSVGLRLAGGNDVGIFVAGIQEGTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLL 597
            .:.|:|..|||:||.|||:.||||..:|.|:.|..:||..||:|||||..|..|:.||:|||:||
  Fly   635 FISFQKEGSVGIRLTGGNEAGIFVTAVQPGSPASLQGLMPGDKILKVNDMDMNGVTREEAVLFLL 699

Mouse   598 EIPKGETVTILAQSRADVYRDILACGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGK 662
            .:.  :.:.::.|...:.|.:::...|||||.|::||.|:..:...:||..|:||||:|||::|.
  Fly   700 SLQ--DRIDLIVQYCKEEYDEVVTNQRGDSFHIKTHFHCDNPSKGEMAFKAGDVFRVIDTLHNGV 762

Mouse   663 LGHWLAVRIG---NELEKGLIPNKSRAEQMASVQ-NAQRE--NAGD-RADFWRMRGQRSSGGVKK 720
            :|.|..::||   .|:::|:||||||||::|:.| ||.::  ||.: |.:|:|.|  ||:....|
  Fly   763 VGSWQVLKIGRGHQEMQRGVIPNKSRAEELATAQFNATKKEMNANESRGNFFRRR--RSTHRRSK 825

Mouse   721 NL-RKSREDLAAAVSVSTKFPAYEKVLLREAGFKRPVVLFGPIADIAMERLATELPDLFQT-AKT 783
            :| |::.:|:..:.|:| ||||||:|:||..||.||||||||::|:|.||||.:.||.|.| .:.
  Fly   826 SLSRENWDDVVFSDSIS-KFPAYERVVLRHPGFVRPVVLFGPVSDLARERLAKDFPDKFSTPLQD 889

Mouse   784 EPKDAGSEKSSGVVRLNTVRQIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTIR 848
            :.|.|.:.....:|||:.:|.::::.||||||:||.|||.|||.|::|:|||...||:..:|.:|
  Fly   890 DDKSAATSGKCRIVRLSNIRDVMDRGKHALLDITPNAVDRLNYAQFYPVVIFLKTDSKHVIKQLR 954

Mouse   849 QRLSPTSNKSSRKLFDQANKLKKTCSHLFTATINVNSANDGWFGSLKDSIQQQQNEAVWVSEGK- 912
            ..|...::|||:||.:|..||::..||:|:..|.: |..:.|:..|:|||..||:.|||:||.|
  Fly   955 HGLPKAAHKSSKKLLEQCQKLERVWSHIFSTQIAL-SDEESWYRKLRDSIDLQQSGAVWMSESKP 1018

Mouse   913 MEGMDDDAEDRMSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELEEPAEEPLVSSITRSSE 977
            :|.:.||      :|..|....||..|...||.|.:.|...:.:...|.:     ||.:   ||:
  Fly  1019 VESLSDD------FLFPMTTSRLSYASSPESDLELSPGPSASLSLGNLPQ-----LVKA---SSD 1069

Mouse   978 P--VQHEENIRKSSPEPRAQMRRAASRDQLRDASPPPAFKP-EPPKARSQNREDSFDYSKSNLPA 1039
            |  ..:::|:.:             .||.:.:..|||...| :.....:.||..:.|.||.::
  Fly  1070 PSIATNQDNLDR-------------DRDIIGEGLPPPYTVPYDHAVPANPNRRQTMDSSKYSI-- 1119

Mouse  1040 TAGSEIP--------GGSTKGYPPPIAAKPAFG--RPILKP-----STPVPMP--------ESEE 1081
             .|:.:|        ||.|....|    :..:|  .|.|.|     |.|..:|        .:..
  Fly  1120 -YGTNVPPQQQQPGVGGDTAAVRP----QSLYGINAPDLPPRIDRQSKPGDIPLNTSGSSSRNGT 1179

Mouse  1082 VGESTEE--------QEDAPRSVLGRVKIF-----EKMDHKAKLQRMQ----ELQEAQNARI--- 1126
            :|.|.:|        |:|.....:.|..:.     |.:|.:.:.|:..    |.|...||::
  Fly  1180 LGRSAQERLFGKAVVQDDVQAEYITRNALVGSGAAETLDRQQQQQQQTHASLERQARLNAQLKAN 1244

Mouse  1127 ------------------------EIAQKH---------PDIYAVPIKAPKPDAGLPP----HMS 1154
                                    ::|.::         .|:.:||....:|   |||    |..
  Fly  1245 GVGAGGGGASTYDSVSSYDSYNNTQMAMQNLGRLGPNAPDDLKSVPNANGRP---LPPTGQSHEY 1306

Mouse  1155 SRPPEP------------QKAPSR-LYQDTRGSYGSDPEEEEYRQQLAAHSKRGYYSQPSR 1202
            .|.|..            |.:|.| .|.|...|...||.....::.    |..|..|.|.:
  Fly  1307 GRTPHDHRSFGGPNDLNRQSSPGRPHYHDMNASRNIDPRNGTPQRP----SNLGLESSPRK 1363

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tjp2	XP_006526967.1	PDZ1_ZO1-like	50..136	CDD:467209	48/85 (56%)
		PDZ2_ZO1-like_ds	327..405	CDD:467210	33/81 (41%)
		PDZ3_ZO1-like_domain	530..611	CDD:467211	35/80 (44%)
		SH3_ZO-2	625..687	CDD:212960	31/64 (48%)
		GuKc	723..902	CDD:214504	81/179 (45%)
pyd	NP_001246998.1	PDZ1_ZO1-like	249..335	CDD:467209	49/87 (56%)
		PDZ2_ZO1-like_ds	397..479	CDD:467210	33/81 (41%)
		PDZ3_ZO1-like_domain	632..711	CDD:467211	36/88 (41%)
		SH3_ZO	729..790	CDD:212793	27/60 (45%)
		GuKc	831..1007	CDD:214504	80/177 (45%)
		ZU5	2264..2365	CDD:459941