DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tjp1 and pyd

DIOPT Version :9

Sequence 1:	XP_006540841.1	Gene:	Tjp1 / 21872	MGIID:	98759	Length:	1875	Species:	Mus musculus
Sequence 2:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster

Alignment Length:	2332	Identity:	626/2332 - (26%)
Similarity:	938/2332 - (40%)	Gaps:	602/2332 - (25%)

- Green bases have known domain annotations that are detailed below.

Mouse    20 RERSGDKMK-YQKYLTVLQMAIGVTPSNRGSLLPLKRKLWVTPSSENPHGATSTVSQGKPSLRRI 83
            |||.||:.: |.:.:..|..|:|            ||     ...:|......|.|....|.||
  Fly   190 RERGGDRDRPYIRNVDDLLQALG------------KR-----DGGDNNSNLLETASTHSSSQRR- 236

Mouse    84 KGRLHRSKSLDSIDFCELTSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIV 148
                 |.|..|              ...||.|||.:.|.||:|||||:|||||||||.:|:.||.
  Fly   237 -----RFKKGD--------------RTTWEYHTVAVTRVPGYGFGIAVSGGRDNPHFANGDPSIA 282

Mouse   149 ISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSHPD 213
            :||||||||||.:||.|||:..|||||::|||:|.|||.||.||...::.::|:    :|::
  Fly   283 VSDVLKGGPAEDRLQVNDRIISVNGVSLENVEYATAVQVLRDSGNTVQLVVKRR----VPLN--- 340

Mouse   214 PEPVSDNEDDSYDEEVHDPRAGRGALANRRSEKSWARDRSASRERSLSPRSDRRSVASSQPAKPT 278
              |:  |...:...:.....:..|.:||.....:.....|.|:..||    :...|.::...:|.
  Fly   341 --PI--NAAGAVQHQHSHSLSSVGLMANGSGGVAPTPITSLSQPNSL----NSSLVQNASSGQPI 397

Mouse   279 KVTLVKSRKNEEYGLRLASHIFVKEIS---QDSLAARDGNIQEGDVVLKINGT-VTENMSLTDAK 339
            ||||.|..|.::||:.|...:||||||   ::.|.|...::||||::.:|:.| ..:.|||.:||
  Fly   398 KVTLTKGGKKDDYGVVLGCRLFVKEISSKAREQLNANGYSLQEGDIITRIHNTNCGDTMSLKEAK 462

Mouse   340 TLIERSKGKLKMVVQRD-ERATLLNVPDLSDSI-HSAN----ASERDDISEIQSLASDHSGRSHD 398
            .:|:..|.:|.:||.|| ...|.::..:|::|. |.|:    |:.:..:|...|     |..:.:
  Fly   463 KIIDGCKERLNLVVLRDITNQTAVSQLNLNNSASHQASGNIYATHQPQVSGCSS-----SNNNLE 522

Mouse   399 RP--PRRSQSRSPDQRSEPSDHSTQSPQQPSNGSLRSREEERMSKPGAISTPVKHVDDHPPKAVE 461
            .|  |..:...|.:...:|...::..|.  .||:..:.|:..::..|....|:          ::
  Fly   523 DPYLPGGASYSSQNLYVQPPTRTSNGPN--INGNGLNDEKSNLTPRGRSRGPI----------MD 575

Mouse   462 EVTVEKNEKQ-TPTL---------PEPKPVYAQVGQPDVDLPVSPSDGALPNSAHEDGIL----- 511
            .|::::.::. |||.         |.|.|            |...|.||    |.||...
  Fly   576 GVSLQQLDRPVTPTRGRSAAIDEPPRPPP------------PRGSSGGA----AQEDFYSSRRQL 624

Mouse   512 ---RPSM--KLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNI 571
               |.|.  :.:.|:|..|||:||.|||:.||||..|...|||:.:||..||:||:||::|...:
  Fly   625 YEERQSAEPRFISFQKEGSVGIRLTGGNEAGIFVTAVQPGSPASLQGLMPGDKILKVNDMDMNGV 689

Mouse   572 IREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEVF 636
            .|||||||||.|.  :.:.::.|..|:.|..:|.:..||||:|:|||..:..|...::|..|:||
  Fly   690 TREEAVLFLLSLQ--DRIDLIVQYCKEEYDEVVTNQRGDSFHIKTHFHCDNPSKGEMAFKAGDVF 752

Mouse   637 RVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPK---TAGGDRADFWRFR 698
            ||:|||:||.:|||..::||:.|:|::||:||||:|||:||:.|:...|   .|...|.:|:|.|
  Fly   753 RVIDTLHNGVVGSWQVLKIGRGHQEMQRGVIPNKSRAEELATAQFNATKKEMNANESRGNFFRRR 817

Mouse   699 GL--RSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDI 761
            ..  |.||...|::.:|:......:|||||||||||..||:|||.:|||::|:|||:||::.||.
  Fly   818 RSTHRRSKSLSRENWDDVVFSDSISKFPAYERVVLRHPGFVRPVVLFGPVSDLARERLAKDFPDK 882

Mouse   762 YQI-AKSEPRDAGTDHRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDS 825
            :.. .:.:.:.|.|..:.. |:||..|:.::|:.||||||:||||||||||||:||:|:||..||
  Fly   883 FSTPLQDDDKSAATSGKCR-IVRLSNIRDVMDRGKHALLDITPNAVDRLNYAQFYPVVIFLKTDS 946

Mouse   826 KQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQL 890
            |..:|.:|..|...:.||::||.|:..||.:...|:|:|.|.| |..:.||..|:::|..||:..
  Fly   947 KHVIKQLRHGLPKAAHKSSKKLLEQCQKLERVWSHIFSTQIAL-SDEESWYRKLRDSIDLQQSGA 1010

Mouse   891 VWVSEGKADGATSDD--LDLHDDRLSYLSAPGSEYSMYSTDSRHTS-----DYEDTDTEGGAYTD 948
            ||:||.|...:.|||  ..:...||||.|:|.|:..:....|...|     ......::....|:
  Fly  1011 VWMSESKPVESLSDDFLFPMTTSRLSYASSPESDLELSPGPSASLSLGNLPQLVKASSDPSIATN 1075

Mouse   949 QELDETLNDEV--GTPPESAITRS----SEPVRE---DSSGMHHENQTYPPYSPQ---------A 995
            |:..:...|.:  |.||...:...    :.|.|.   |||.........||...|         .
  Fly  1076 QDNLDRDRDIIGEGLPPPYTVPYDHAVPANPNRRQTMDSSKYSIYGTNVPPQQQQPGVGGDTAAV 1140

Mouse   996 QPQAIHRIDSPGLKPASQQKAEASSPVPYLSPETTPASS-------------------------A 1035
            :||:::.|::|.|.|...::::     |...|..|..||                         |
  Fly  1141 RPQSLYGINAPDLPPRIDRQSK-----PGDIPLNTSGSSSRNGTLGRSAQERLFGKAVVQDDVQA 1200

Mouse  1036 SAVNHNVSV-----------------TNVSLEEPAPAPPTSHASQPGC----------------- 1066
            ..:..|..|                 |:.|||..|.......|:..|.
  Fly  1201 EYITRNALVGSGAAETLDRQQQQQQQTHASLERQARLNAQLKANGVGAGGGGASTYDSVSSYDSY 1265

Mouse  1067 ------------LGAPSAEAAHVVLRGEGPPLPPHADPAKVYRKEPYSEEMM-RQNHILKQPALG 1118
                        ||..:.:....|....|.|||| ...:..|.:.|:..... ..|.:.:|.:.|
  Fly  1266 NNTQMAMQNLGRLGPNAPDDLKSVPNANGRPLPP-TGQSHEYGRTPHDHRSFGGPNDLNRQSSPG 1329

Mouse  1119 HP--------------GQRPDKEPNLAYE--PQLPYIEKQA-------SRDLEQPSYRY------ 1154
            .|              ...|.:..||..|  |:.|.:|.:.       :..:.|..|..
  Fly  1330 RPHYHDMNASRNIDPRNGTPQRPSNLGLESSPRKPLVETKTDYGKYSRNNSVTQADYTKLPKTAP 1394

Mouse  1155 -------EVSSYTDQFS---------------------RNYDHRLRFEDRIPTYE---------D 1182
                   .||:...|.:                     :||        |.|...         .
  Fly  1395 HGVVPPPNVSNGQGQMNGSGTPSSNGSGPFKPVPPPKPKNY--------RPPVQSGGSSGSGGTT 1451

Mouse  1183 QWSYYDDKQP-------YQPRPFENQHPRDL--------------DSRQHPEEASERGYFQRFEE 1226
            .|...|...|       |.|.|..:.:.:..              ..:|.|......|.:.  :.
  Fly  1452 PWENGDSGSPRSPNGFYYPPTPSHHHYGQQATPGSPSNGHMQPPPPQQQQPTYGGSNGNYG--QA 1514

Mouse  1227 PAPLSYDSRTRYE---------------------------QLPRTSTLRH-------EEQPAPAY 1257
            |.|.||.....|.                           .||..:..||       .||...|:
  Fly  1515 PPPQSYPQANGYNGNGHHYNGGSGTGPYIAPHRGMPPPIGNLPPHTPERHALDLAGSREQRGSAF 1579

Mouse  1258 EV-----------HNRYRPEAQPYS-------STGPKSSEPKQ-YFDQYPRSYEQVP---PP--- 1297
            |:           |:....|.:||.       :..|.::.|.| :..|..||..:.|   ||
  Fly  1580 ELYRKPQIGATAGHHHNMSEMEPYDERYDDYYNMPPPAAHPSQGHHMQRSRSAPRYPHERPPHAQ 1644

Mouse  1298 ------GFTSKTGHYEPL--------------HGAAVVPPLIPSSQQKPEVLPS----------- 1331
                  .:.:..||.:|.              ||..:.||.:|..::|..||.|
  Fly  1645 DPNYYGHYGTSRGHSQPRQQYSQHHQQQYYDDHGLEMGPPPLPPHKKKKSVLKSPLVALKNALLK 1709

Mouse  1332 ATKPQPPPPTLTEEEEDP--AMKPQSVLTRVKM--------------FE---------------- 1364
            :|:|.....::.|.|..|  ..:.||:|.|...              ||
  Fly  1710 STRPLRRMNSMVEPERKPKGLRRQQSMLERGVQRPYYPDEYPTYPAGFEERAHGGQGMMQPHSQD 1774

Mouse  1365 -----------------NKRSASLENKK---DVNDTASFKP------------------------ 1385
                             |....:||.:.   ::.:|....|
  Fly  1775 AYYQRGGHYAPQQQEMMNSTYQNLEGEDIYGNIGNTVPRMPHHQDNGYGYDQYDLYANRACIDLE 1839

Mouse  1386 ---PEVASK-------------------------PPGASLAGP--KPVPQSQFSEHDKTLYRLPE 1420
               .|.|:.                         ||...:..|  :..||..:...:.. |.||:
  Fly  1840 RRQAEAAAASGGRNGRRIVRRHSTTTADRGGNPGPPRRPMISPGYEQDPQEIYQTRNGA-YMLPD 1903

Mouse  1421 PQKPQVKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFESKPSA-HLPAGHH------SEPAKP 1478
            .::   .|..:::....:.|....|...::..|..||..:.:... ||.....      |:..:.
  Fly  1904 QRR---APSSEVMTRRRFYPGAANEQTEEEPLYQSRREMQREMQRNHLYQSKREMQERISQGKRD 1965

Mouse  1479 VHSQSQPNFSSYSSKFLGSYTSYDYLKRNIKWG--KPETDAVDRSFSEKRYDPAQATPPPPPLPS 1541
            :..:..|..||..|:...|...|. .:|..|..  |..:...|:.:..:|........|......
  Fly  1966 MEREFSPQSSSSQSEASNSEAIYQ-SRREAKESALKTRSQLRDQIYQTRREALDSMAEPIYVSKR 2029

Mouse  1542 QYSQPAPPLSSSSLHI-----------HSKGAQGEGNSVSLDFQ------NSYMSKPDPPPSQ-- 1587
            ...:|||...:....|           ..|..:.|...|.::.|      :|.:|:.|...|.
  Fly  2030 GMGRPAPIYETREESILQSRENETDEKKEKECKTEQIQVEINAQPEEQIEDSTLSRSDLQKSSDT 2094

Mouse  1588 --SKPATFRPPTREDPPQTFYPQKSFPDKAPV-NGAEQTQKTITPVYNRFTPKPYTSSARPFERK 1649
              ..||  |.|..:|.......::....:.|. :.|:||::......|.........|....:..
  Fly  2095 VIENPA--RAPLVQDEVDDDEEEEVQDQRDPAESSADQTEQPTAIENNLHNEGMVEQSQNDSDDV 2157

Mouse  1650 FESPKFNHNLLPSETVHKPEL--SSKTPTSPKTLMKAHSSTQPPEFDSGVETFSVHT------DK 1706
            ||:......|.|.....:|..  |.:.|.....::|  .:..||....|....|:.|      ..
  Fly  2158 FEAADKVSPLAPPPAPVQPPTPRSGRAPFHISNILK--RTAPPPSSPIGDSCTSIETQYTSQASL 2220

Mouse  1707 PKYQMNNIST-------MPKAVPVS--PSAVEEDEDEDGHTVV-----ATARGIFNSNGGVLSSI 1757
            |....|..||       :|.|.||:  |||       :|....     :|:||.|:||||.|:..
  Fly  2221 PVGPPNATSTPFSSSMSLPIAGPVNNQPSA-------NGRFPTLPREPSTSRGFFDSNGGTLADK 2278

Mouse  1758 ETGVSIIIPQGAIPEGIEQEIYFKVC--RDNSIL--PPLDKEKGETLLSPLVMCGPHGLKFLKPV 1818
            ...||:.||.||||.|:.|||||.|.  |....:  ||||.|.|||:|||||||||.||:||.||
  Fly  2279 LWHVSLQIPPGAIPAGVRQEIYFTVSDPRMGQAVGGPPLDMENGETMLSPLVMCGPQGLEFLVPV 2343

Mouse  1819 ELRLPHCASMTPDGWSFALKSSDSSSGDPKTWQNKCLPGDPNYLVGANCVSVLIDHF 1875
            .|.:||||..|. ....|||::||.......|.|..||.:    ..|:.|||.:|||
  Fly  2344 TLNIPHCAGRTA-SLGLALKATDSEKNLHTEWDNIDLPSN----AAAHTVSVKVDHF 2395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tjp1	XP_006540841.1	PDZ_signaling	115..200	CDD:238492	54/84 (64%)
		PDZ	276..356	CDD:214570	34/83 (41%)
		PDZ	518..594	CDD:366185	37/75 (49%)
		SH3_ZO-1	610..674	CDD:212959	33/63 (52%)
		GuKc	708..887	CDD:214504	82/179 (46%)
		PHA03247	<1006..1705	CDD:223021	178/1092 (16%)
		PRK10263	<1227..>1403	CDD:236669	59/371 (16%)
		ZU5	1742..1841	CDD:366307	57/102 (56%)
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492	54/84 (64%)
		PDZ_signaling	396..477	CDD:238492	33/80 (41%)
		PDZ_signaling	633..710	CDD:238492	37/78 (47%)
		SH3_ZO	729..790	CDD:212793	30/60 (50%)
		GuKc	831..1007	CDD:214504	81/177 (46%)
		ZU5	2263..2351	CDD:279170	51/87 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845442
Domainoid	1	1.000	113	1.000	Domainoid score	I6130
eggNOG	1	0.900	-	-		E1_KOG3580
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	625	1.000	Inparanoid score	I865
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001438
OrthoInspector	1	1.000	-	-		otm42386
orthoMCL	1	0.900	-	-		OOG6_103390
Panther	1	1.100	-	-	O	PTHR13865
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3326
SonicParanoid	1	1.000	-	-		X1692
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.780