Protein Alignment PTK2B and Abl

DIOPT Version :10

• Sequence 1: NP_004094.3
• Gene: PTK2B / 2185
• HGNCID: 9612
• Length: 1009
• Species: Homo sapiens
• Sequence 2: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Alignment Length: 926
• Identity: 219/926 - (23%)
• Similarity: 338/926 - (36%)
• Gaps: 303/926 - (32%)

Human   316 GQAVLQLGIEGA---------PQALSIKTSSLAEAENMADLIDGYCRLQGEHQGSLIIHPRKDGE 371
            ||..:.|..||.         |......|.. |:...:|:|:..:   ...|:|..:|.|.....
  Fly   304 GQRSISLRYEGRVYHYRISEDPDGKVFVTQE-AKFNTLAELVHHH---SVPHEGHGLITPLLYPA 364

Human   372 KRNSLPQIPMLNLEARRSHLSESCSIESDIYAEIPDETLRRPGGPQYGIAREDVVLNRILGEGFF 436
            .:.:.|.:..|:.|                    |||         :.|.|.|:::...||.|.:
  Fly   365 PKQNKPTVFPLSPE--------------------PDE---------WEICRTDIMMKHKLGGGQY 400

Human   437 GEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIVKLIGIIEEEPT-WI 500
            |||||.|:..:..   .|||||.|:| |:..|: |:.||.|||.:.||::|:|||:...||. :|
  Fly   401 GEVYEAVWKRYGN---TVAVKTLKED-TMALKD-FLEEAAIMKEMKHPNLVQLIGVCTREPPFYI 460

Human   501 IMELYPYGELGHYL-ERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVK 564
            |.|...:|.|..:| ...:.:|..:.|:..:.||...|:||||.|.:|||:|.||.||...:.||
  Fly   461 ITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVK 525

Human   565 LGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWL 629
            :.||||:|.:.|:.|...:..:.||||.:||.:.:.:|:|.||||.|.|.:|||.::|..|:..:
  Fly   526 VADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAI 590

Human   630 ENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTELVCSLSDVYQMEKDI--AME 692
            :..||...|:||.|:.:|..|||.:|.||.:||.:|.:|||.|..:..:|..::| |..|  |:|
  Fly   591 DLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALEHMFQ-ESSITEAVE 654

Human   693 QERNARYR---------------------------------------TPKI----------LEPT 708
            ::.||...                                       ||::          |.|.
  Fly   655 KQLNANATSASSSAPSTSGVATGGGATTTTAASGCASSSSATASLSLTPQMVKKGLPGGQALTPN 719

Human   709 AFQEPPPKPSRPKYRPPPQTNLLAPKLQFQVPEG-------------------------LCASSP 748
            |....|.:  :....|..:|...:.||.....:|                         |.:||.
  Fly   720 AHHNDPHQ--QQASTPMSETGSTSTKLSTFSSQGKGNVQMRRTTNKQGKQAPAPPKRTSLLSSSR 782

Human   749 TLTSPMEYPSP-----VNSLHTPPLHR---HNVFKR---------------HSMREEDFIQPSSR 790
            ..|...|.|:.     ::.|.|..:|:   .|.|.:               |.:|.:...|..|.
  Fly   783 DSTYREEDPANARCNFIDDLSTNGIHKLKTANYFSQTLSRNFKTQIPTHHTHQIRTQQQQQQQSV 847

Human   791 EEAQQLWEAEKVKMRQILDKQQKQ----------------------MVEDYQWLRQE-------- 825
            ::.||:  ......:|...:||||                      :..|...|.|.
  Fly   848 QQQQQI--VPLSVQQQAHQQQQKQQQYSIKKSSSCSSFLYDILFRGLARDINSLTQRYDSETDPA 910

Human   826 ------------EKSLDPMVYMNDKSPLT-----------------PEKEVGYLEF--------- 852
                        |:||..::    .:|:|                 |.....:..|
  Fly   911 ADPDTDATGDSLEQSLSQVI----AAPVTNKMQHSLHSGGGGGGIGPRSSQQHSSFKRPTGTPVM 971

Human   853 ---------------------TGPPQKPPRLGAQSIQPTANLDRTDDLVYLNVMELVRAVLELKN 896
                                 .|||...|..|...:..:|:......|..:||.::|       |
  Fly   972 GNRGLETRQSKRSQLHSQAPGPGPPSTQPHHGNNGVVTSAHPITVGALDVMNVKQVV-------N 1029

Human   897 ELCQLPPEGYVVVVKNVGLTLRKLIGSVDD----------LLPSLPSSSRTEIEGTQKLLNKDLA 951
            ....||.          |..:...:.|::|          ..||||.::........:|..|  |
  Fly  1030 RYGTLPK----------GARIGAYLDSLEDSSEAAPALPATAPSLPPANGHATPPAARLNPK--A 1082

Human   952 ELINKMRL----------AQQNAVTSLSEECKRQMLTASHTLAV---------------DAKNLL 991
            ..|...::          .|.||..||: :.:|...|...|:..               .|..:.
  Fly  1083 SPIPPQQMIRSNSSGGVTMQNNAAASLN-KLQRHRTTTEGTMMTFSSFRAGGSSSSPKRSASGVA 1146

Human   992 DAVDQAKVLANLAHPP 1007
            ..|..|  ||||..||
  Fly  1147 SGVQPA--LANLEFPP 1160

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTK2B	NP_004094.3	FERM_N_2	39..137	CDD:436229
		B41	41..254	CDD:214604
		FERM_C_FAK1	261..368	CDD:270011	14/60 (23%)
		PTKc_FAK	418..687	CDD:133187	109/270 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	701..725		6/33 (18%)
		Interaction with TGFB1I1. /evidence=ECO:0000250	801..1009		56/331 (17%)
		Focal adhesion targeting (FAT)	868..1009		36/175 (21%)
		Focal_AT	872..1001	CDD:460992	29/163 (18%)
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784
		SH2_ABL	268..363	CDD:198189	14/62 (23%)
		PTKc_Abl	382..644	CDD:270645	108/266 (41%)
		FABD	1584..1723	CDD:197885