Protein Alignment PTK2B and FER

DIOPT Version :10

• Sequence 1: NP_004094.3
• Gene: PTK2B / 2185
• HGNCID: 9612
• Length: 1009
• Species: Homo sapiens
• Sequence 2: NP_524288.3
• Gene: FER / 41118
• FlyBaseID: FBgn0000723
• Length: 1325
• Species: Drosophila melanogaster
• Alignment Length: 282
• Identity: 111/282 - (39%)
• Similarity: 163/282 - (57%)
• Gaps: 13/282 - (4%)

Human   402 YAEIP-----DETLRRP-GGPQYGIAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCK 460
            ::|:|     ...|||| ...::.::.:||||...:|.|.||:||:   ...|..|::||||||:
  Fly  1034 HSELPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYK---AKLKSTKLDVAVKTCR 1095

Human   461 KDCTLDNKEKFMSEAVIMKNLDHPHIVKLIGI-IEEEPTWIIMELYPYGELGHYLERNKNSLKVL 524
            .....:.|.||:.|..|:|..|||:||||||| ::::|..|:|||...|.|..||.:|.|.|...
  Fly  1096 MTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTR 1160

Human   525 TLVLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKA-SVTRLP 588
            ..:.........|.||||.||:|||:|.||.||.....||:.|||:||  |:|:|..: .:.::|
  Fly  1161 QQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR--EEEEYIVSDGMKQIP 1223

Human   589 IKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPV 653
            :||.:||::||.::|:..|||.:.:.||||.|.|..|:..:.|......::.|.|:|.|...|..
  Fly  1224 VKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEE 1288

Human   654 LYTLMTRCWDYDPSDRPRFTEL 675
            :|.||.:||..|...||.|.|:
  Fly  1289 MYRLMLQCWAADAESRPHFDEI 1310

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTK2B	NP_004094.3	FERM_N_2	39..137	CDD:436229
		B41	41..254	CDD:214604
		FERM_C_FAK1	261..368	CDD:270011
		PTKc_FAK	418..687	CDD:133187	105/260 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	701..725
		Interaction with TGFB1I1. /evidence=ECO:0000250	801..1009
		Focal adhesion targeting (FAT)	868..1009
		Focal_AT	872..1001	CDD:460992
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	1/4 (25%)
		PTKc_Fes_like	1067..1315	CDD:270637	101/249 (41%)