Protein Alignment PTK2B and Fak

DIOPT Version :10

• Sequence 1: NP_004094.3
• Gene: PTK2B / 2185
• HGNCID: 9612
• Length: 1009
• Species: Homo sapiens
• Sequence 2: NP_001137718.1
• Gene: Fak / 37233
• FlyBaseID: FBgn0020440
• Length: 1500
• Species: Drosophila melanogaster
• Alignment Length: 1371
• Identity: 373/1371 - (27%)
• Similarity: 565/1371 - (41%)
• Gaps: 430/1371 - (31%)

Human    52 PGKNFKL----VKCTVQTEIREIITSILLSGRIGPNIRLAECYGLRLKHMKSDEIHWLHPQMTVG 112
            |.|:||.    ||.||...||..:..:...||. |:|   :.|..|:.:|.:.|:.||....::.
  Fly    29 PNKSFKAVRFNVKETVFHVIRRTVEDLGTDGRT-PSI---QRYACRMLNMITKEVIWLARSTSMQ 89

Human   113 EVQ--------DKYECLHVEAE-----------------WRYDLQIRYLPEDFMESLKEDRTTLL 152
            :|.        ...:|.:.::|                 ||.:|::||:|.:..|..:||:.|..
  Fly    90 KVLSHILTPGCSNVDCPNNQSELDEVLLEHGRRITDNRVWRVELRVRYVPNNIQELFEEDKATCF 154

Human   153 YFYQQLRNDYMQRYASKVSEGMALQLGCLELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPKQ 217
            |::.|::.|::|...:.:...:|:||.||.:|.:||::...|.|||.:.:.:|||:|...|.|:.
  Fly   155 YYFNQVKEDFIQANVTAIDTEVAVQLCCLGIRHYFKNITVKAPDKKQHIDYIEKEIGFKSFLPQS 219

Human   218 MQENLKPKQFRKMIQQTFQQYASLREEECVMKFFNTLAGFANIDQETYRCELIQGWNITVDLVIG 282
            :....|||..:|:||..:::..:..:.|.:.:||:.|......:.|.:...|...|||:..|.:|
  Fly   220 VIATSKPKNLKKLIQVGYKKVYNYNDIEYLTRFFDLLKNIYLTNFEQFSVTLSSAWNISGILHVG 284

Human   283 PK-GIRQLTSQDAKPTCLAEFKQIRSIR-C-LPLEE----GQ------------------AVLQL 322
            |. ||...|...|....:|:||.:.||: | ||.|:    |:                  ..:::
  Fly   285 PHIGISYQTHPQASLKNVAQFKDVVSIKTCTLPKEKLSKSGENTTEPELQNFNCNCQKIKTQIKI 349

Human   323 GIEGAPQALSIKTSSLAEAENMADLIDGYCRLQGEHQGSLIIHPRKDGEKRNSLPQIPM-LNLEA 386
            ......:.|.|..:.:..||::||||||||||..:.....|.|...:....:|...:|. ..|.:
  Fly   350 SASNNVEDLVITCNGINTAESIADLIDGYCRLLSKDLEFTIWHRETNASNEDSAKALPNDATLGS 414

Human   387 RRSHLSESCSIESDIYAEI----PDETLRRPGGPQYGIAREDVVLNRILGEGFFGEVYEGVYT-- 445
            .:|..|:...:.:|.||||    .:.....|....|.:.|..:..:..:|.|.||:||.|.||
  Fly   415 NKSTSSQGKPMLTDDYAEIGLLEGEGDYSTPTVRNYELDRALITPSAKIGVGQFGDVYVGTYTLP 479

Human   446 ----------------------NHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIVK 488
                                  :.:.:.|.||:||||.:...:..|.|::||.||:..|||||::
  Fly   480 KLGKGKNLAGNGKNSNSDQRNADSRPDVIQVAIKTCKANDDPEKTENFLAEAYIMQKFDHPHIIR 544

Human   489 LIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVR 553
            ||||....|.||:|||...|||..||:.|...|...||:.|..|:..|::||||...||||||.|
  Fly   545 LIGICSVMPIWIVMELAKLGELRAYLKTNSERLSHGTLLKYCYQLSTALSYLESKKFVHRDIAAR 609

Human   554 NILVASPECVKLGDFGLSRYIEDEDYYKASVT-RLPIKWMSPESINFRRFTTASDVWMFAVCMWE 617
            |:||:||.||||.||||||::.|:.||.::.| .|||||||||||||||||||||||||.||:||
  Fly   610 NVLVSSPTCVKLADFGLSRWVSDQSYYHSTPTVALPIKWMSPESINFRRFTTASDVWMFGVCIWE 674

Human   618 ILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTELVCSL--- 679
            ||..|.:||..::|.|||..||.|:|||.|..|||.||:||::||.|:|..||.|..:..:|
  Fly   675 ILMLGVKPFQGVKNSDVILKLENGERLPLPPNCPPRLYSLMSQCWAYEPLKRPNFKRIKETLHEI 739

Human   680 --SDVYQMEKDIAMEQERNARYRTPKILEPTAFQEPPPKPSRPKYRPP-----------PQTNLL 731
              .|.....:.:..||.:.|   :...:.......||.||||..:.|.           |||.::
  Fly   740 LIEDSINSSETLKREQRKVA---SMSWIGSDDIDIPPSKPSRVMHDPDITGLMPETTGLPQTYII 801

Human   732 A------PKLQFQ--------------------VPEGLCASSPT--------------------- 749
            |      .||..:                    :..||..|:|.
  Fly   802 AQNPAVLAKLMMENQKRGINPAAYTTPASVFNTLAVGLDDSNPNVSLKTTKLPAADLLKLDPIAE 866

Human   750 ----------------LTSPM-------------------------------------------- 754
                            |.:|:
  Fly   867 SERLRSQFSANSSASQLANPLTASVNPHESLNSHQAGMFTGSLPSKSSFVVCPPQTEEHMQAENI 931

Human   755 -------------------EYPSPVNSLHT-----------------------PPLHRHNVFKR- 776
                               ..|.|..::|:                       ||.:..|..:|
  Fly   932 SNPSVSKVSGYSLYGSLERHQPPPAKAMHSKGGSLERHQSLMSAQNLVFYNTKPPPNCTNTAERS 996

Human   777 ---------HSMREE---------------DF----------------------IQPSS------ 789
                     |:.|::               ||                      ::|:.
  Fly   997 RSMERNTYFHAYRQQMKTSIECEALPEEIYDFGGIGLKTCVSARQQPKFSPMVNVRPAELGQVQN 1061

Human   790 -----------------------------REEAQQLW--------------------------EA 799
                                         :.|.::.|                          :|
  Fly  1062 TDCMGLQQNIPMDSFGVISPHNLDESLRHQREMERQWMTSGPQSITVNPNISISEGAACLATLQA 1126

Human   800 EKV-----------KMRQILDKQQKQMVEDYQWLRQEE--KSLD-PMVYMNDKSPLTPEKEVGYL 850
            |.:           |:||    |||....|.:||.|||  :|.. |...:||.     :.::..|
  Fly  1127 EAMGNQGIHNVLGEKLRQ----QQKDSNSDSEWLIQEELLRSCSIPQGSLNDH-----QAQMFKL 1182

Human   851 EF--TGPPQKPPRLGAQS--IQPTANL-------------------------------------- 873
            :|  .||...|....:.|  :.|.|||
  Fly  1183 DFMSAGPSSLPDCSNSSSRPMTPNANLSSLKSNHSSADHLSSLTSAEEQMGSNARNLGSAVPSRP 1247

Human   874 -DRTDDLVYLNVMELVRAVLELKNELCQLPPEGYVVVVKNVGLTLRKLIGSVDDLLPSLPSSSRT 937
             :|.||.||.....:|::::.|...:.:...|||:.:|||||:.||.|:.|||.:....|:.:..
  Fly  1248 PNRADDEVYCATTLVVKSIMALSQGVEKANTEGYLELVKNVGVKLRNLLTSVDKISIIFPAQALK 1312

Human   938 EIEGTQKLLNKDLAELINKMRLAQQNAVTSLSEECKRQMLTASHTLAVDAKNLLDAVDQAKVLAN 1002
            |::...::|:||:.||::.||||||.:.|:|..|.::.||:|:|.||:|||||.|.||..:....
  Fly  1313 EVQMAHQVLSKDMHELVSAMRLAQQYSDTTLDCEYRKSMLSAAHVLAMDAKNLFDVVDSIRQRYQ 1377

Human  1003 LAHPPA 1008
            ...||:
  Fly  1378 HLFPPS 1383

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTK2B	NP_004094.3	FERM_N_2	39..137	CDD:436229	28/113 (25%)
		B41	41..254	CDD:214604	64/230 (28%)
		FERM_C_FAK1	261..368	CDD:270011	38/131 (29%)
		PTKc_FAK	418..687	CDD:133187	142/298 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	701..725		6/23 (26%)
		Interaction with TGFB1I1. /evidence=ECO:0000250	801..1009		79/265 (30%)
		Focal adhesion targeting (FAT)	868..1009		57/180 (32%)
		Focal_AT	872..1001	CDD:460992	53/167 (32%)
Fak	NP_001137718.1	B41	24..267	CDD:214604	66/241 (27%)
		FERM_B-lobe	152..257	CDD:271216	32/104 (31%)
		FERM_C_FAK1	263..394	CDD:270011	38/130 (29%)
		PTKc_FAK	450..744	CDD:133187	141/293 (48%)
		Focal_AT	1250..1376	CDD:460992	51/125 (41%)