DRSC/TRiP Functional Genomics Resources

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Protein Alignment PTK2B and Src42A

DIOPT Version :10

Sequence 1:NP_004094.3 Gene:PTK2B / 2185 HGNCID:9612 Length:1009 Species:Homo sapiens
Sequence 2:NP_001400996.1 Gene:Src42A / 35524 FlyBaseID:FBgn0264959 Length:1606 Species:Drosophila melanogaster


Alignment Length:658 Identity:179/658 - (27%)
Similarity:287/658 - (43%) Gaps:125/658 - (18%)


- Green bases have known domain annotations that are detailed below.


Human   108 QMTVGEVQDKYECLHVEAEWRYDLQIRYLPEDFMESLKEDRTTLLYFYQQ-LRNDYMQRYASKVS 171
            |.|.|:.:.|.:  ..:|:.|..:....||.|     .|:..|.:...|: |..::.|....|.:
  Fly   987 QETTGKEETKPK--RTQAKRRIGVTNLLLPLD-----SEELYTRIIAQQRGLDKEHSQEPEEKCA 1044

Human   172 --EGMALQLGCLELRRFFKDMPHNALDKKSNFELLEKEVGLDLF---FPKQMQENLKPKQFRKMI 231
              |.|..:               |||.|.|:.:.:...|.:...   .|.:.:.:||..:..:..
  Fly  1045 SEEQMCTR---------------NALTKSSSLDAISLSVAISPASSPSPPRPRRSLKQHRCLQQH 1094

Human   232 QQT-----------FQQYASLREEECVMKFFN--------------------------------- 252
            |||           .|..:|....:.:.::.|                                 
  Fly  1095 QQTPLAKKHSLDNCLQVVSSTTSRQPLRRWSNQTPLKCTCHPATEELPLTAIEKSRSLPAACSAS 1159

Human   253 ---TLAGFANIDQE--TYRCELIQGWNITVDLVIGPKGIRQLTSQDAKPTCLAE----FKQIRSI 308
               |.|..:.|||.  |.:|     :..| .|....||..:..|:..:...|.|    |::|:.|
  Fly  1160 CSHTCAHLSVIDQSPATTKC-----FGKT-SLTTAKKGKSRRLSEFTRGEFLNEKSWYFRKIKRI 1218

Human   309 RC-----LPLEEGQAVLQLGIEGAPQALSIKTSSLAEAENMADLIDG----YCRLQGEHQGSLII 364
            ..     ||..|..|.|            |:.|.....:....:.||    :.|::...:|...|
  Fly  1219 EAEKKLLLPENEHGAFL------------IRDSESRHNDYSLSVRDGDTVKHYRIRQLDEGGFFI 1271

Human   365 HPRKDGEKRNSLPQIPMLNLEARRSHLSESCSIESDIYAEIPD------ETLRRPGGPQYGIARE 423
            ..|........|.:....:.:....:|.:.| ::::.::.:.:      |.|......|:.|.|.
  Fly  1272 ARRTTFRTLQELVEHYSKDSDGLCVNLCKPC-VQTNSFSGVFEIEKPVTEGLSHRTRDQWEIDRT 1335

Human   424 DVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIVK 488
            .:...|.||.|.||:|:||::.|    ...||:||.|.. |:|.|: |::||.|||.|.|..:::
  Fly  1336 SLKFVRKLGSGQFGDVWEGLWNN----TTPVAIKTLKSG-TMDPKD-FLAEAQIMKKLRHTKLIQ 1394

Human   489 LIGIIE-EEPTWIIMELYPYGELGHYLER---NKNSLKVLTLVLYSLQICKAMAYLESINCVHRD 549
            |..:.. |||.:||.||..:|.|..||:.   ...|||:.||:..:.||...||||||.|.:|||
  Fly  1395 LYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRD 1459

Human   550 IAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFRRFTTASDVWMFAVC 614
            :|.||:||.....||:.||||:|.|::::|......|.||||.:||:.|:.:|:..||||.|.:.
  Fly  1460 LAARNVLVGDGNIVKIADFGLARLIKEDEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGIL 1524

Human   615 MWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTELVCSL 679
            :.|::::|:.|:..:.|.:|:..:|.|.|:|:|..|.|.||.:|..||..||..||.|..|...|
  Fly  1525 LTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETLQWKL 1589

Human   680 SDVYQMEK 687
            .|.|..::
  Fly  1590 EDFYTSDQ 1597

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PTK2BNP_004094.3 FERM_N_2 39..137 CDD:436229 6/28 (21%)
B41 41..254 CDD:214604 32/198 (16%)
FERM_C_FAK1 261..368 CDD:270011 26/121 (21%)
PTKc_FAK 418..687 CDD:133187 111/272 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 701..725
Interaction with TGFB1I1. /evidence=ECO:0000250 801..1009
Focal adhesion targeting (FAT) 868..1009
Focal_AT 872..1001 CDD:460992
Src42ANP_001400996.1 SH2_Src_Src42 1210..1301 CDD:198233 18/102 (18%)
PTKc_Frk_like 1328..1596 CDD:270653 112/273 (41%)
Blue background indicates that the domain is not in the aligned region.

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