DRSC/TRiP Functional Genomics Resources

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Protein Alignment PTK2B and Btk

DIOPT Version :10

Sequence 1:NP_004094.3 Gene:PTK2B / 2185 HGNCID:9612 Length:1009 Species:Homo sapiens
Sequence 2:NP_476745.1 Gene:Btk / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster


Alignment Length:374 Identity:121/374 - (32%)
Similarity:190/374 - (50%) Gaps:53/374 - (14%)


- Green bases have known domain annotations that are detailed below.


Human   355 QGEHQGSLIIHPRKDGEK-------RNSLPQIPMLNLEARRS-----HLSESCSIESDIYAEIPD 407
            ||:.:|..::  ||...|       ...:||..:.:...:::     :|||....|:     |||
  Fly   426 QGDKEGCFVV--RKSSTKGLYTLSLHTKVPQSHVKHYHIKQNARCEYYLSEKHCCET-----IPD 483

Human   408 ------------------ETLRRPGGPQYGIARE-------DVVLNRILGEGFFGEVYEGVYTNH 447
                              ....||..|..|::.:       :::|...||.|.||.|..|.:.. 
  Fly   484 LINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRG- 547

Human   448 KGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIVKLIGII-EEEPTWIIMELYPYGELG 511
               .|:.|||..|:...  :::.|:.||.:|..|.||::|:|.|:. :..|.:|:.|...:|.|.
  Fly   548 ---SIDTAVKMMKEGTM--SEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLL 607

Human   512 HYLERNKNSL--KVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYI 574
            :||.|::.:|  .:..|:...:|:.|.|.|||..|.:|||:|.||.||.|...||:.||||:||:
  Fly   608 NYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYV 672

Human   575 EDEDYYKASVTRLPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLE 639
            .|:.|..:..|:.||||..||.:|:.||::.||||.:.|.||||.:.||.|:..|:|.:|:..::
  Fly   673 LDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQ 737

Human   640 KGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTELVCSLSDVYQMEKD 688
            :|..|.||..|...:|.:|..||.:.|.:||.|..|:..|:.|.|...|
  Fly   738 RGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQLALVAQTLTD 786

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PTK2BNP_004094.3 FERM_N_2 39..137 CDD:436229
B41 41..254 CDD:214604
FERM_C_FAK1 261..368 CDD:270011 3/12 (25%)
PTKc_FAK 418..687 CDD:133187 102/278 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 701..725
Interaction with TGFB1I1. /evidence=ECO:0000250 801..1009
Focal adhesion targeting (FAT) 868..1009
Focal_AT 872..1001 CDD:460992
BtkNP_476745.1 PH_Btk 44..222 CDD:269944
SH3_Tec_like 346..399 CDD:212702
SH2_Tec_family 403..505 CDD:198188 15/85 (18%)
PTKc_Tec_like 521..778 CDD:173637 98/262 (37%)
Blue background indicates that the domain is not in the aligned region.

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