DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klf10 and btd

DIOPT Version :9

Sequence 1:	XP_036015210.1	Gene:	Klf10 / 21847	MGIID:	1101353	Length:	547	Species:	Mus musculus
Sequence 2:	NP_511100.1	Gene:	btd / 31912	FlyBaseID:	FBgn0000233	Length:	644	Species:	Drosophila melanogaster

Alignment Length:	469	Identity:	116/469 - (24%)
Similarity:	166/469 - (35%)	Gaps:	139/469 - (29%)

- Green bases have known domain annotations that are detailed below.

Mouse    78 QMREGKMELISEKPREGMHPWDKAEQSDFEAVEALMSMSCDWKSHFKKYLENRPVTPVSDTSEDD 142
            |.::.:.:...::.::...|  :.:|.||.:..||:|                  .|.|.:....
  Fly    66 QQQQQQQQQQQQQQQQQQQP--QQQQHDFLSAAALLS------------------APPSLSGSSS 110

Mouse   143 SLLPGTPDLQTVPAFCLTPPYSPSDFEPSQGSNLTA-------SAPSTG------------HFKS 188
            ....|:..|...|...|..||      |...|..||       ||||:.            .|.|
  Fly   111 GSSSGSSPLYGKPPMKLELPY------PQASSTGTASPNSSIQSAPSSASVSPSIFPSPAQSFAS 169

Mouse   189 FSDAAKPPGAT--PFKEEEKNPLAAPPLPKAQATSVIRHTADAQLCNHQSCPVKAASILNYQDNS 251
            .|.:...|..|  |........||..|...:.::|.....|.|......:..:.||::.:
  Fly   170 ISASPSTPTTTLAPPTTAAAGALAGSPTSSSPSSSAASAAAAAAAAAAAAADLGAAAVAS----- 229

Mouse   252 FRRRTHGNVEATRKNIPCAAVSPNRSK-PEPSTVSDGDEKAGAALYDFAVPSSETVICRSQPAPS 315
                     .|...|...:.:.|.||: |.....||        .|..||..|.:....|.
  Fly   230 ---------AAYGWNTAYSGLGPARSQFPYAQYASD--------YYGNAVGMSSSAAWFSH---- 273

Mouse   316 SPVQKSVLVSSPTVSTGGVPPLPVICQMVPLPANNSLVSTVVPSTPPSQPPAVCSPVLFMGTQVP 380
               |:.:                                 ..|.:..|.|......:.|. ||:.
  Fly   274 ---QERL---------------------------------YQPWSSQSYPGFNFDDIAFQ-TQLQ 301

Mouse   381 EGTVVFVVPQPVVQ-SPRPPVVSPSGTRLSPIAPAPGFSPSAARVTPQIDSSRVRSHICSHPGCG 444
            ..:|....|....: |..||:|.|                         |....:.|||..|||.
  Fly   302 RRSVRCTCPNCTNEMSGLPPIVGP-------------------------DERGRKQHICHIPGCE 341

Mouse   445 KTYFKSSHLKAHVRTHTGEKPFSCSWKGCERRFARSDELSRHRRTHTGEKKFACPMCDRRFMRSD 509
            :.|.|:||||.|:|.||||:||.|  ..|.:||:|||||.||.||||..:.:|||:|.::|.|||
  Fly   342 RLYGKASHLKTHLRWHTGERPFLC--LTCGKRFSRSDELQRHGRTHTNYRPYACPICSKKFSRSD 404

Mouse   510 HLTKHARRHLSAKK 523
            ||:||.:.|...||
  Fly   405 HLSKHKKTHFKDKK 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klf10	XP_036015210.1	KLF10_N	101..436	CDD:409241	64/357 (18%)
		COG5048	441..>491	CDD:227381	30/49 (61%)
		C2H2 Zn finger	441..460	CDD:275368	11/18 (61%)
		C2H2 Zn finger	468..490	CDD:275368	12/21 (57%)
		zf-C2H2	496..518	CDD:395048	12/21 (57%)
		C2H2 Zn finger	498..518	CDD:275368	11/19 (58%)
btd	NP_511100.1	C2H2 Zn finger	338..357	CDD:275368	11/18 (61%)
		zf-H2C2_2	349..374	CDD:290200	15/26 (58%)
		C2H2 Zn finger	365..385	CDD:275368	12/21 (57%)
		zf-H2C2_2	377..402	CDD:290200	13/24 (54%)
		zf-C2H2	391..413	CDD:278523	12/21 (57%)
		C2H2 Zn finger	393..413	CDD:275368	11/19 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910