Protein Alignment Tie1 and tor

DIOPT Version :10

• Sequence 1: NP_035717.2
• Gene: Tie1 / 21846
• MGIID: 99906
• Length: 1134
• Species: Mus musculus
• Sequence 2: NP_476762.1
• Gene: tor / 35717
• FlyBaseID: FBgn0003733
• Length: 923
• Species: Drosophila melanogaster
• Alignment Length: 970
• Identity: 217/970 - (22%)
• Similarity: 348/970 - (35%)
• Gaps: 321/970 - (33%)

Mouse   312 DCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDRIPQILSMATEVEFNI-------GTMPRIN 369
            |||:     ||    .|.|.:       ...:::.::..|....:|:.|.|       ||.|
  Fly    59 DCRI-----NG----TFPGAL-------RKVQENYQMNMICRTESEIVFQIDWVQHSRGTEP--- 104

Mouse   370 CAAAGNPFPVRGSMKLRKPDGTMLLSTKVIVEPDRTTAEFEVPSLTLGDSGFWECRVSTSGGQDS 434
                             .|:.|.::....:.:.::.||      |.|.|..|
  Fly   105 -----------------APNATYIIRVDAVKDDNKETA------LYLSDDNF------------- 133

Mouse   435 RRFKVNVKVPPVPLTAPRLLAKQSRQLVVSPLVSFSGDGPISSVRLHYRPQDSTIAWSAIVVDPS 499
                         |..|.|.:..:..:..   ::..|||..|.:     .:|.|.|.......||
  Fly   134 -------------LILPGLESNSTHNITA---LAMHGDGSYSLI-----AKDQTFATLIRGYQPS 177

Mouse   500 E--NVTLMNLKPKTG--YNVRVQLSRPGEGGEGGWGPSALMTTDCPEPLLQPWLESWHVEGPDRL 560
            :  .|.|:...|:..  :::..::.         |.|||  .::|...:
  Fly   178 KMGAVNLLRFVPQPDDLHHIAAEIE---------WKPSA--ESNCYFDM---------------- 215

Mouse   561 RVSWSLPSV----PLSGDGFLLRLWDGARGQERR-------ENISFPQ-----ARTA-LLTGLTP 608
             ||:|..||    ||.           .:.::|:       :|:.|.:     .||. ::..|..
  Fly   216 -VSYSTNSVNMDEPLE-----------VQFRDRKKLYRHTVDNLEFDKQYHVGVRTVNIMNRLES 268

Mouse   609 GTHYQ-------LDVRLYHCTLLGPASPPAHVHLPPSGPPAPRHLHAQALSDSEIQLMWQHPEAP 666
            ...:.       ||...|:.||..|       |.|.:.....:......|:   :.:.|..|...
  Fly   269 DLQWLPIAVPSCLDWYPYNYTLCPP-------HKPENLTVTQKQYLPNILA---LNITWARPRYL 323

Mouse   667 SGPISKYIVEIQVAGGSGDPQWMDVDRPE--ETSIIVRGLNASTRYLFRVRASVQGLGDWSNTVE 729
            ....:.:|.:: ..||:.....:|.:|..  ...|.|.|.:      |.|....|..|  ...|.
  Fly   324 PDNYTLHIFDL-FKGGTELNYTLDQNRSHFYVPKITVLGSH------FEVHLVAQSAG--GKNVS 379

Mouse   730 EATLGNGLQSEGPVRESRAAEEGLDQQLVLAVVGSVSATCLTILAALLALVCIR-RSCLHRRRTF 793
            ..||..       |.......||...:|||.::  |...|:.:|.:|  ..|.| ||.:...:..
  Fly   380 GLTLDK-------VHRGVLLSEGNMVKLVLFII--VPICCILMLCSL--TFCRRNRSEVQALQMD 433

Mouse   794 TYQSGSGEETILQFSSGTLTLTRRPKPQPEPLSYPVLEWEDITFEDLIGEGNFGQVIRAMIKKDG 858
            ...:.:.|..:....|..|.:|.......|.:....:|...:..:|::|||.||.|.|.:.|
  Fly   434 AKDAKASEFHLSLMDSSGLLVTLSANESLEVMDELEVEPHSVLLQDVLGEGAFGLVRRGVYK--- 495

Mouse   859 LKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLG-ACENRGYLYIAIEYAPYGNLL 922
             |...|:|:||:..::.|...|..|:::|..:|.||||:.::| :......:.:.|||...|:|.
  Fly   496 -KRQVAVKLLKDEPNDEDVYAFKCEIQMLKAVGKHPNIVGIVGYSTRFSNQMMLLIEYCSLGSLQ 559

Mouse   923 DFLR------------------------------------------------------------- 926
            :|||
  Fly   560 NFLREEWKFRQEQNAIGLKKNLEQNVDNRRFNRLPRNSIHDRIEDINNSMLSTVEEESESDQTHS 624

Mouse   927 ----------------------------------------------------------------K 927
                                                                            |
  Fly   625 SRCETYTLTRITNAADNKGYGLEDIENIGGSYIPKTAEAPKDRPKRKLKPQPKKDSKQDFKSDNK 689

Mouse   928 SRVLETDPAF----AREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLA 988
            .|:.|....|    :.:......|....||..|...|.||::|::.:.:||||||||||:..:.:
  Fly   690 KRIFENKEYFDCLDSSDTKPRIPLKYADLLDIAQQVAVGMEFLAQNKVVHRDLAARNVLISVDRS 754

Mouse   989 SKIADFGLSRG---EEVYVKK-TMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTP 1049
            .|||||||||.   |.||.|. ..|:||::|:|:|||.:.|||::||||||||||:||.:|||.|
  Fly   755 IKIADFGLSRDVYHENVYRKSGGSGKLPIKWLALESLTHQVYTSQSDVWSFGVLLYEITTLGGMP 819

Mouse  1050 YCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLEA 1109
            |..::.::|.:.|.||:||::|..|..|::.||..||...|..||.|:.:..:||.|:.|
  Fly   820 YPSVSPSDLLQLLRQGHRMKRPEGCTQEMFSLMESCWSSVPSHRPTFSALKHRLGGMILA 879

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie1	NP_035717.2	ig	127..208	CDD:395002
		Furin-like	220..336	CDD:395614	7/23 (30%)
		EGF_Lam	225..263	CDD:238012
		Ig	348..439	CDD:472250	15/97 (15%)
		Ig strand B	366..370	CDD:409353	1/3 (33%)
		Ig strand C	382..386	CDD:409353	0/3 (0%)
		Ig strand E	407..411	CDD:409353	1/3 (33%)
		Ig strand F	421..426	CDD:409353	1/4 (25%)
		Ig strand G	434..437	CDD:409353	0/2 (0%)
		fn3	447..518	CDD:394996	15/74 (20%)
		fn3	546..628	CDD:394996	19/105 (18%)
		fn3	641..725	CDD:394996	15/85 (18%)
		PTKc_Tie1	832..1128	CDD:270671	116/412 (28%)
tor	NP_476762.1	PTKc	479..873	CDD:270623	112/397 (28%)