DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tie1 and Dscam1

DIOPT Version :9

Sequence 1:	NP_035717.2	Gene:	Tie1 / 21846	MGIID:	99906	Length:	1134	Species:	Mus musculus
Sequence 2:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster

Alignment Length:	971	Identity:	185/971 - (19%)
Similarity:	313/971 - (32%)	Gaps:	265/971 - (27%)

- Green bases have known domain annotations that are detailed below.

Mouse    40 FLTCVSGEAGAGRSSDPPLLLEKDDRIVRT---FPPGQPLYLARNGSHQVTLRGFSKPSDLVGVF 101
            ||.||     ||.:..|.:..|.|.:.:..   :..||  |:..||.....|...|..::..|::
  Fly   451 FLKCV-----AGGNPTPEISWELDGKKIANNDRYQVGQ--YVTVNGDVVSYLNITSVHANDGGLY 508

Mouse   102 SCVGGAG---ARRTRVLYVHNSPGAHLFPDKVTHTVNKGDTAVLSAHVHKEKQTDVIWKN----- 158
            .|:..:.   |..:..|.|:..|.......|   .:..|:|.:::..|.......::|:.
  Fly   509 KCIAKSKVGVAEHSAKLNVYGLPYIRQMEKK---AIVAGETLIVTCPVAGYPIDSIVWERDNRAL 570

Mouse   159 ----------NG--------------SYFNTLDWQEADDGRFQLQLQNVQPPSSGIYSATYLEAS 199
                      ||              :|......||....|..|::|.:..|.  |....|.:..
  Fly   571 PINRKQKVFPNGTLIIENVERNSDQATYTCVAKNQEGYSARGSLEVQVMVLPQ--IVPFAYEDLI 633

Mouse   200 PLGSA--FFRLIVRGCGAGRWGPGCVKDCPGCLHGGV---CHDHDGECVCPPGFTGTRCEQA--- 256
            .:|.:  .|..|.:|            |.|..:|...   ..|:..:.|.|...|....|:.
  Fly   634 NMGDSIDLFCQIQKG------------DRPIKVHWSFERSAGDYGFDQVQPQMRTNRISEKTSMI 686

Mouse   257 -------CREGRFGQSCQEQCPGTAGCRGLTFCLPDPYGCSCGSGWRGSQCQEACAPGHFGADCR 314
                   ...||.......:...|.....||..:|        ..|......:|.|.   |:|.:
  Fly   687 SIPSASPAHTGRDTCIASNKAGTTTYSVDLTVNVP--------PRWILEPTDKAFAQ---GSDAK 740

Mouse   315 LQCQCQN------------GGTCDRFSGCVCPSGWHGVHCEKSDRIPQ----------------- 350
            ::|:...            |.|...:.           ..:|||.|..
  Fly   741 VECKADGFPKPQVTWKKAVGDTPGEYK-----------DLKKSDNIRVEEGTLHVDNIQKTNEGY 794

Mouse   351 -----------------ILSMATEVEFNIGTMPRINCAAAGNPFPVRGSMKLRKPDGTMLLSTKV 398
                             ::|:....||.  ...|...|..|.|..::...|..||.|.:.....:
  Fly   795 YLCEAINGIGSGLSAVIMISVQAPPEFT--EKLRNQTARRGEPAVLQCEAKGEKPIGILWNMNNM 857

Mouse   399 IVEP---DRTTAEFEV------PSLTL-----GDSGFWECRVSTSGGQDSRRFKVNV-KVPPVPL 448
            .::|   :|.|...|:      .||::     .||..:.|..:.:.|.|.....:.| :||.:|.
  Fly   858 RLDPKNDNRYTIREEILSTGVMSSLSIKRTERSDSALFTCVATNAFGSDDASINMIVQEVPEMPY 922

Mouse   449 TAPRLLAKQSRQLVVSPLVSFSGDGPISSVRLHYRPQDSTIAWSAI--VVDP--SENVTLMNLKP 509
             |.::|.|..|.:.:|....:.|:.|:....:.::  .|..:||.|  |:.|  :....:..|.|
  Fly   923 -ALKVLDKSGRSVQLSWAQPYDGNSPLDRYIIEFK--RSRASWSEIDRVIVPGHTTEAQVQKLSP 984

Mouse   510 KTGYNVRVQLSRPGEGGEGGWGPSALMTTDCP---------EPLLQPWLESWHVEGPDRLRVSWS 565
            .|.||:|:.........:.....:.:...:.|         ||:.|           ..:||:|.
  Fly   985 ATTYNIRIVAENAIGTSQSSEAVTIITAEEAPSGKPQNIKVEPVNQ-----------TTMRVTWK 1038

Mouse   566 LPSVPLSGDGFLLRLWDGARGQERR-----ENISF----PQARTALLTGLTPGTHYQLDVRLYHC 621
             |......:|.:|..:.|.:.....     |.|:|    .:.....|..|...|.|.:.::.::.
  Fly  1039 -PPPRTEWNGEILGYYVGYKLSNTNSSYVFETINFITEEGKEHNLELQNLRVYTQYSVVIQAFNK 1102

Mouse   622 TLLGPASPPAH---VHLPPSGPPAPRHLHAQALSDSEIQLMWQHP--EAPSGPISKYIVEIQVAG 681
            ...||.|....   ....||.||:  ......|:...|::.|..|  |:.:|.|..|    :|..
  Fly  1103 IGAGPLSEEEKQFTAEGTPSQPPS--DTACTTLTSQTIRVGWVSPPLESANGVIKTY----KVVY 1161

Mouse   682 GSGDPQWMD-----VDRPEETSIIVRGLNASTRYLFRVRASVQGLGDWSNTVEEATLGNGL---- 737
            ...| :|.|     ..:...:..::.||...|.|..:|.|:..|             |:|:
  Fly  1162 APSD-EWYDETKRHYKKTASSDTVLHGLKKYTNYTMQVLATTAG-------------GDGVRSVP 1212

Mouse   738 ---QSEGPVRESRAAEEGLDQQLVLAVVGSVSATCLTILAALLALVCIRRSCLHRRRTFTYQSGS 799
               |:|..|.|:....:.|       |:|:.            |::...|.........|
  Fly  1213 IHCQTEPDVPEAPTDVKAL-------VMGNA------------AILVSWRPPAQPNGIIT----- 1253

Mouse   800 GEETILQFSSGTLTLTRRPKPQPEPLSYPVLEWED-------ITFEDLIGEGNFGQVIRAM 853
             :.|:...:.|..|.|:..|.....:|:...|.|.       :|....||||...:.|.||
  Fly  1254 -QYTVYSKAEGAETETKTQKVPHYQMSFEATELEKNKPYEFWVTASTTIGEGQQSKSIVAM 1313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie1	NP_035717.2	ig	127..208	CDD:278476	18/111 (16%)
		IG_like	131..210	CDD:214653	17/109 (16%)
		EGF_Lam	225..263	CDD:238012	10/50 (20%)
		EGF_CA	312..343	CDD:238011	4/42 (10%)
		ig	353..439	CDD:278476	22/99 (22%)
		IG	367..441	CDD:214652	19/87 (22%)
		fn3	447..518	CDD:278470	20/74 (27%)
		fn3	546..628	CDD:278470	17/90 (19%)
		FN3	640..732	CDD:238020	21/98 (21%)
		PTKc_Tie1	832..1128	CDD:270671	9/29 (31%)
		TyrKc	835..1103	CDD:197581	8/19 (42%)
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653
		Ig	269..340	CDD:143165
		IG_like	353..425	CDD:214653
		IGc2	361..413	CDD:197706
		I-set	433..527	CDD:254352	20/82 (24%)
		IGc2	446..517	CDD:197706	18/72 (25%)
		I-set	533..618	CDD:254352	12/87 (14%)
		IGc2	544..607	CDD:197706	8/62 (13%)
		Ig	641..714	CDD:143165	14/84 (17%)
		IGc2	735..804	CDD:197706	9/82 (11%)
		I-set	819..914	CDD:254352	21/96 (22%)
		Ig	833..921	CDD:299845	20/87 (23%)
		FN3	918..1011	CDD:238020	21/95 (22%)
		FN3	1018..1116	CDD:238020	20/109 (18%)
		FN3	1124..1217	CDD:238020	23/112 (21%)
		FN3	1222..1312	CDD:238020	21/114 (18%)
		Ig	1339..1406	CDD:299845
		FN3	1409..1499	CDD:238020
		FN3	1504..1584	CDD:238020
		Dscam_C	1890..2008	CDD:289151
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000