Protein Alignment ACSL4 and FAA4

DIOPT Version :10

• Sequence 1: NP_075266.1
• Gene: ACSL4 / 2182
• HGNCID: 3571
• Length: 711
• Species: Homo sapiens
• Sequence 2: NP_013974.1
• Gene: FAA4 / 855288
• SGDID: S000004860
• Length: 694
• Species: Saccharomyces cerevisiae
• Alignment Length: 691
• Identity: 221/691 - (31%)
• Similarity: 349/691 - (50%)
• Gaps: 58/691 - (8%)

Human    57 SPYRSVTHFDSLAVIDI-PGADTLDKLFDHAVSKFGKKDSLGTREILS-----------EENEMQ 109
            :|.|::...|...:..| ..|.||.:......:|.||:|.:..|:|:.           .:.:.:
Yeast    19 APRRNIRVKDQPLIRPINSSASTLYEFALECFTKGGKRDGMAWRDIIDIHETKKTIVKRVDGKDK 83

Human   110 PNGKVFKKLILGNYKWMNYLEVNRRVNNFGSGLTALGLKP--KNTIAIFCETRAEWMIAAQTCFK 172
            |..|.:....|..|..|.|.|:...:::.|.||..:|:||  :|...||..|..:||.....|..
Yeast    84 PIEKTWLYYELTPYITMTYEEMICVMHDIGRGLIKIGVKPNGENKFHIFASTSHKWMKTFLGCMS 148

Human   173 YNFPLVTLYATLGKEAVVHGLNESEASYLITSVELLESKLKTALLDISCVKHIIY---VD----- 229
            ...|:||.|.|||:..::|.:.|:::..:.|..:|| |||...|.....||.:|:   :|
Yeast   149 QGIPVVTAYDTLGESGLIHSMVETDSVAIFTDNQLL-SKLAVPLKTAKNVKFVIHNEPIDPSDKR 212

Human   230 -NKAINKA---------EYPEGFEIHSMQSVEELGSNPENLGIPPSRPTPSDMAIVMYTSGSTGR 284
             |..:.||         |.....:|:|...:.|:|...:: .:....|.|.|.|.:||||||||.
Yeast   213 QNGKLYKAAKDAVDKIKEVRPDIKIYSFDEIIEIGKKAKD-EVELHFPKPEDPACIMYTSGSTGT 276

Human   285 PKGVMMHHSNLIAGMTGQCERIPG-LGPKDTYIGYLPLAHVLELTAEISCFTYGCRIGYSSPLTL 348
            ||||::.|.|::||:.|....:.| :||.|..|.:|||||:.|||.|...|.:...:||::..||
Yeast   277 PKGVVLTHYNIVAGIGGVGHNVIGWIGPTDRIIAFLPLAHIFELTFEFEAFYWNGILGYANVKTL 341

Human   349 SDQSSKIKKGSKGDCTVLKPTLMAAVPEIMDRIYKNVMSKVQEMNYIQKTLFKIGYDYKLEQIKK 413
            :..|:   :..:||....|||:|..|..:.:.:.|.:::|:.|:....:|||...|..|...|
Yeast   342 TPTST---RNCQGDLMEFKPTVMVGVAAVWETVRKGILAKINELPGWSQTLFWTVYALKERNI-- 401

Human   414 GYDAPLCNL---LLFKKVKALLGGNVRMMLSGGAPLSPQTHRFMNVCFCCPIGQGYGLTESCGAG 475
                |...|   |:||:::...|||:|.:|:||:.:|....:|:: ...||:..||||||.....
Yeast   402 ----PCSGLLSGLIFKRIREATGGNLRFILNGGSAISIDAQKFLS-NLLCPMLIGYGLTEGVANA 461

Human   476 TVTEVTDYTTGRVGAPLICCEIKLKDWQEGGYTINDKPNPRGEIVIGGQNISMGYFKNEEKTAED 540
            .|.|...:..|..|..:.....||.|.::.||...   |.:||::..|..|...|:||.|:||..
Yeast   462 CVLEPEHFDYGIAGDLVGTITAKLVDVEDLGYFAK---NNQGELLFKGAPICSEYYKNPEETAAA 523

Human   541 YSVDENGQRWFCTGDIGEFHPDGCLQIIDRKKDLVKLQAGEYVSLGKVEAALKNCPLIDNICAFA 605
            ::.|    .||.||||.|:.|.|.::||||||:|||...|||::|.|:|:..::.|.:.|||.:|
Yeast   524 FTDD----GWFRTGDIAEWTPKGQVKIIDRKKNLVKTLNGEYIALEKLESIYRSNPYVQNICVYA 584

Human   606 KSDQSYVISFVVPNQKRLTLLAQQKGVEGTWVDI---CNNPAMEAEILKEIREAANAMKLERFEI 667
            ..::...:..||||...|:.||.:.|:.....|:   .:...::..:.|::...|.:..|...|:
Yeast   585 DENKVKPVGIVVPNLGHLSKLAIELGIMVPGEDVESYIHEKKLQDAVCKDMLSTAKSQGLNGIEL 649

Human   668 PIKVRLSPEPWTPETGLVTDAFKLKRKELRNHYLKDIERMY 708
            ...:....|.||||.||||.|.||||:::......|:||:|
Yeast   650 LCGIVFFEEEWTPENGLVTSAQKLKRRDILAAVKPDVERVY 690

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACSL4	NP_075266.1	LC_FACS_euk1	121..696	CDD:341294	201/601 (33%)
FAA4	NP_013974.1	LC_FACS_euk1	96..678	CDD:341294	201/600 (34%)
		PRK04319	<230..>285	CDD:235279	21/55 (38%)