Protein Alignment ACSL4 and FAA3

DIOPT Version :10

• Sequence 1: NP_075266.1
• Gene: ACSL4 / 2182
• HGNCID: 3571
• Length: 711
• Species: Homo sapiens
• Sequence 2: NP_012257.1
• Gene: FAA3 / 854808
• SGDID: S000001271
• Length: 694
• Species: Saccharomyces cerevisiae
• Alignment Length: 714
• Identity: 211/714 - (29%)
• Similarity: 352/714 - (49%)
• Gaps: 83/714 - (11%)

Human    36 AKKKNAMAKRIKAKPTSDKPGSPYRSVTHFDSLAVIDIPGADTLDKLFDHAVSKFGKKDSLGTRE 100
            |.::|.   |:|.:|..    .|..|             .|.||.:......:|.||:|.:..|:
Yeast    19 APRRNV---RVKKRPLI----RPLNS-------------SASTLYEFALECFNKGGKRDGMAWRD 63

Human   101 ILSEENEMQPNGKVFKKLILGN---------------YKWMNYLEVNRRVNNFGSGLTALGLKP- 149
            ::    |:....|...:.:.|.               ||.|.|.|:...:::.|.||..:|:||
Yeast    64 VI----EIHETKKTIVRKVDGKDKSIEKTWLYYEMSPYKMMTYQELIWVMHDMGRGLAKIGIKPN 124

Human   150 -KNTIAIFCETRAEWMIAAQTCFKYNFPLVTLYATLGKEAVVHGLNESEASYLITSVELLESKLK 213
             ::...||..|..:||.....|.....|:||.|.|||:..::|.:.|:|::.:.|..:|| :|:.
Yeast   125 GEHKFHIFASTSHKWMKIFLGCISQGIPVVTAYDTLGESGLIHSMVETESAAIFTDNQLL-AKMI 188

Human   214 TALLDISCVKHIIY---VD--------------NKAINK-AEYPEGFEIHSMQSVEELG-SNPEN 259
            ..|.....:|.:|:   :|              ..|||| .|.....:|:|.:.|.::| .:.:.
Yeast   189 VPLQSAKDIKFLIHNEPIDPNDRRQNGKLYKAAKDAINKIREVRPDIKIYSFEEVVKIGKKSKDE 253

Human   260 LGIPPSRPTPSDMAIVMYTSGSTGRPKGVMMHHSNLIAGMTGQCERIPG-LGPKDTYIGYLPLAH 323
            :.:.|  |.|.|:|.:||||||...||||::.|.|:::|:.|....:.| :|..|..:.:|||||
Yeast   254 VKLHP--PEPKDLACIMYTSGSISAPKGVVLTHYNIVSGIAGVGHNVFGWIGSTDRVLSFLPLAH 316

Human   324 VLELTAEISCFTYGCRIGYSSPLTLSDQSSKIKKGSKGDCTVLKPTLMAAVPEIMDRIYKNVMSK 388
            :.||..|...|.:...:||.|..||::.|:   :..|||....|||:|..|..:.:.:.|.::.|
Yeast   317 IFELVFEFEAFYWNGILGYGSVKTLTNTST---RNCKGDLVEFKPTIMIGVAAVWETVRKAILEK 378

Human   389 VQEMNYIQKTLFKIGYDYKLEQIK-KGYDAPLCNLLLFKKVKALLGGNVRMMLSGGAPLSPQTHR 452
            :.::..:.:.:|...|..|.:.:. .|:    .:.::||||:...||:::.:::||:.:|....:
Yeast   379 ISDLTPVLQKIFWSAYSMKEKSVPCTGF----LSRMVFKKVRQATGGHLKYIMNGGSAISIDAQK 439

Human   453 FMNVCFCCPIGQGYGLTESCGAGTVTEVTDYTTGRVGAPLICCEIKLKDWQEGGYTINDKPNPRG 517
            |.::.. ||:..||||||:.....|.|...:..|.||..:.....||.|.::.||...   |.:|
Yeast   440 FFSIVL-CPMIIGYGLTETVANACVLEPDHFEYGIVGDLVGSVTAKLVDVKDLGYYAK---NNQG 500

Human   518 EIVIGGQNISMGYFKNEEKTAEDYSVDENGQRWFCTGDIGEFHPDGCLQIIDRKKDLVKLQAGEY 582
            |:::.|..:...|:||..:||..::.|    .||.||||.|:.|.|.|:||||:|:|||...|||
Yeast   501 ELLLKGAPVCSEYYKNPIETAVSFTYD----GWFRTGDIVEWTPKGQLKIIDRRKNLVKTLNGEY 561

Human   583 VSLGKVEAALKNCPLIDNICAFAKSDQSYVISFVVPNQKRLTLLAQQKGVEGTWVDICN---NPA 644
            ::|.|:|:..::...:.|||.:|...:...:..||||...|:..|.:..:.....||.|   :.|
Yeast   562 IALEKLESVYRSNSYVKNICVYADESRVKPVGIVVPNPGPLSKFAVKLRIMKKGEDIENYIHDKA 626

Human   645 MEAEILKEIREAANAMKLERFEIPIKVRLSPEPWTPETGLVTDAFKLKRKELRNHYLKDIERMY 708
            :...:.||:...|.:..|...|:...:....|.||||.|.||.|.||||:|:......::||:|
Yeast   627 LRNAVFKEMIATAKSQGLVGIELLCGIVFFDEEWTPENGFVTSAQKLKRREILAAVKSEVERVY 690

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACSL4	NP_075266.1	LC_FACS_euk1	121..696	CDD:341294	190/615 (31%)
FAA3	NP_012257.1	LC_FACS_euk1	95..678	CDD:341294	189/600 (32%)