Protein Alignment ACSL4 and FAA1

DIOPT Version :10

• Sequence 1: NP_075266.1
• Gene: ACSL4 / 2182
• HGNCID: 3571
• Length: 711
• Species: Homo sapiens
• Sequence 2: NP_014962.3
• Gene: FAA1 / 854495
• SGDID: S000005844
• Length: 700
• Species: Saccharomyces cerevisiae
• Alignment Length: 683
• Identity: 214/683 - (31%)
• Similarity: 351/683 - (51%)
• Gaps: 83/683 - (12%)

Human    82 LFDHAVSKFGK---KDSLGTREILSEENEMQPNGKVFKKLILG-----NYKWMNYLEVNRRVNNF 138
            :::..:..|.|   .:::|.|::    .|:....|...|.:.|     ..|||.|...:...|:|
Yeast    42 VYEFVLECFQKNKNSNAMGWRDV----KEIHEESKSVMKKVDGKETSVEKKWMYYELSHYHYNSF 102

Human   139 ----------GSGLTALGLKPK--NTIAIFCETRAEWM---IAAQTCFKYNFPLVTLYATLGKEA 188
                      |.||..:||||.  :.:.::..|..:||   :.||:   ...|:||.|.|||::.
Yeast   103 DQLTDIMHEIGRGLVKIGLKPNDDDKLHLYAATSHKWMKMFLGAQS---QGIPVVTAYDTLGEKG 164

Human   189 VVHGLNESEASYLITSVELLESKLK--TALLDISCVKHIIYVD-----------------NKAIN 234
            ::|.|.::.:..:.|...||.|.:|  .|..|   ||:||:.|                 :.|||
Yeast   165 LIHSLVQTGSKAIFTDNSLLPSLIKPVQAAQD---VKYIIHFDSISSEDRRQSGKIYQSAHDAIN 226

Human   235 K-AEYPEGFEIHSMQSVEELGSNPEN-LGIPPSRPTPSDMAIVMYTSGSTGRPKGVMMHHSNLIA 297
            : .|.....:..|...:.:||....| :.:.|  |...|:..:||||||||.||||::.|||::|
Yeast   227 RIKEVRPDIKTFSFDDILKLGKESCNEIDVHP--PGKDDLCCIMYTSGSTGEPKGVVLKHSNVVA 289

Human   298 GMTG-QCERIPGLGPKDTYIGYLPLAHVLELTAEISCFTYGCRIGYSSPLTLSDQSSKIKKGSKG 361
            |:.| ....:..:|..|..|.:|||||:.||..|:..|.:|..|||::..||:..|   .:..:|
Yeast   290 GVGGASLNVLKFVGNTDRVICFLPLAHIFELVFELLSFYWGACIGYATVKTLTSSS---VRNCQG 351

Human   362 DCTVLKPTLMAAVPEIMDRIYKNVMSKVQEMNYIQKTLFKIGYDYKLE----QIKKGYDAPLCNL 422
            |....|||:|..|..:.:.:.|.:::::..:.::.|.:|...|:.||.    .|..|  ..|.|
Yeast   352 DLQEFKPTIMVGVAAVWETVRKGILNQIDNLPFLTKKIFWTAYNTKLNMQRLHIPGG--GALGN- 413

Human   423 LLFKKVKALLGGNVRMMLSGGAPLSPQTHRFMNVCFCCPIGQGYGLTESCGAGTVTEVTDYTTGR 487
            |:|||::...||.:|.:|:||:|:|.....|: ....||:..||||||:|.:.|:.:..::..|.
Yeast   414 LVFKKIRTATGGQLRYLLNGGSPISRDAQEFI-TNLICPMLIGYGLTETCASTTILDPANFELGV 477

Human   488 VGAPLICCEIKLKDWQEGGYTINDKPNPRGEIVIGGQNISMGYFKNEEKTAEDYSVDENGQRWFC 552
            .|....|..:||.|.:|.||...   |.:||:.|.|.|::..|:||||:|::..:.|    .||.
Yeast   478 AGDLTGCVTVKLVDVEELGYFAK---NNQGEVWITGANVTPEYYKNEEETSQALTSD----GWFK 535

Human   553 TGDIGEFHPDGCLQIIDRKKDLVKLQAGEYVSLGKVEAALKNCPLIDNICAFAKSDQSYVISFVV 617
            ||||||:..:|.|:||||||:|||...|||::|.|:|:..::...:.|||.:|...::..:..:|
Yeast   536 TGDIGEWEANGHLKIIDRKKNLVKTMNGEYIALEKLESVYRSNEYVANICVYADQSKTKPVGIIV 600

Human   618 PNQKRLTLLAQQKGV---EGTWVDICNNPAMEAEILK----EIREAANAMKLERFEIPIKVRLSP 675
            ||...||.||::.|:   :.:.::| .|...:|:::|    ::.:......|...|:...:....
Yeast   601 PNHAPLTKLAKKLGIMEQKDSSINI-ENYLEDAKLIKAVYSDLLKTGKDQGLVGIELLAGIVFFD 664

Human   676 EPWTPETGLVTDAFKLKRKELRNHYLKDIERMY 708
            ..|||:.|.||.|.|||||::.|.....::.:|
Yeast   665 GEWTPQNGFVTSAQKLKRKDILNAVKDKVDAVY 697

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACSL4	NP_075266.1	LC_FACS_euk1	121..696	CDD:341294	205/627 (33%)
FAA1	NP_014962.3	LC_FACS_euk1	95..685	CDD:341294	200/612 (33%)
		Adenylate forming domain, Class I superfamily	<217..>281	CDD:473059	22/65 (34%)