Protein Alignment ACSL4 and acsl4a

DIOPT Version :10

• Sequence 1: NP_075266.1
• Gene: ACSL4 / 2182
• HGNCID: 3571
• Length: 711
• Species: Homo sapiens
• Sequence 2: NP_956943.1
• Gene: acsl4a / 393622
• ZFINID: ZDB-GENE-040426-1565
• Length: 706
• Species: Danio rerio
• Alignment Length: 707
• Identity: 523/707 - (73%)
• Similarity: 616/707 - (87%)
• Gaps: 1/707 - (0%)

Human     5 LNVLTIILLPVHLLITIYSALIFIPWYFLTNAKKKNAMAKRIKAKPTSDKPGSPYRSVTHFDSLA 69
            :::..::|.|||.::.:||.|.|:||||||.|::|.|:|||:|:|.|||:|..||||...|:||.
Zfish     1 MDLSAVLLFPVHAVVWLYSLLSFLPWYFLTGAQEKKALAKRLKSKSTSDQPDGPYRSTDRFESLV 65

Human    70 VIDIPGADTLDKLFDHAVSKFGKKDSLGTREILSEENEMQPNGKVFKKLILGNYKWMNYLEVNRR 134
            .:|.||.||||||||:||.:|||.|.|||||:||.:||.|||||||||||||.|||.:|.|::..
Zfish    66 TVDFPGKDTLDKLFDYAVERFGKLDCLGTREVLSGDNETQPNGKVFKKLILGEYKWKSYEELDIE 130

Human   135 VNNFGSGLTALGLKPKNTIAIFCETRAEWMIAAQTCFKYNFPLVTLYATLGKEAVVHGLNESEAS 199
            |::|||||.|||.:||:||||||||||||||.||.||:.||||||.|||||::||.:|||||..:
Zfish   131 VSHFGSGLAALGQQPKSTIAIFCETRAEWMITAQACFRRNFPLVTFYATLGEDAVAYGLNESGVT 195

Human   200 YLITSVELLESKLKTALLDISCVKHIIYVDNKAINKAEYPEGFEIHSMQSVEELGSNPENLGIPP 264
            :|:||:||||:|||:.||.|..:|||||||:|::|.|.:|:|.:||||.||||||:.||||..|.
Zfish   196 HLVTSIELLETKLKSVLLQIPNLKHIIYVDSKSMNTAGFPQGIQIHSMHSVEELGAKPENLNRPI 260

Human   265 SRPTPSDMAIVMYTSGSTGRPKGVMMHHSNLIAGMTGQCERIPGLGPKDTYIGYLPLAHVLELTA 329
            .:|.|||:|::||||||||||||||:.|||||.||.||||||||||||||||.|||||||||:||
Zfish   261 VKPVPSDLAVIMYTSGSTGRPKGVMIIHSNLIGGMAGQCERIPGLGPKDTYIAYLPLAHVLEMTA 325

Human   330 EISCFTYGCRIGYSSPLTLSDQSSKIKKGSKGDCTVLKPTLMAAVPEIMDRIYKNVMSKVQEMNY 394
            ||||.|||||||||||.||||||:||||||||||:||||:||||||||||||.||||||||||:.
Zfish   326 EISCVTYGCRIGYSSPQTLSDQSTKIKKGSKGDCSVLKPSLMAAVPEIMDRINKNVMSKVQEMSC 390

Human   395 IQKTLFKIGYDYKLEQIKKGYDAPLCNLLLFKKVKALLGGNVRMMLSGGAPLSPQTHRFMNVCFC 459
            :|:||||..|||||||||||||||||| :|||||:|||||||||||||||||||.|.||||:|||
Zfish   391 VQRTLFKPAYDYKLEQIKKGYDAPLCN-ILFKKVRALLGGNVRMMLSGGAPLSPATQRFMNICFC 454

Human   460 CPIGQGYGLTESCGAGTVTEVTDYTTGRVGAPLICCEIKLKDWQEGGYTINDKPNPRGEIVIGGQ 524
            ||:||||||||:|||||:|||.||:||||||||||||:|||||.|||||..|||:|||||:|||.
Zfish   455 CPVGQGYGLTETCGAGTITEVADYSTGRVGAPLICCEVKLKDWAEGGYTKRDKPHPRGEILIGGP 519

Human   525 NISMGYFKNEEKTAEDYSVDENGQRWFCTGDIGEFHPDGCLQIIDRKKDLVKLQAGEYVSLGKVE 589
            |::|||::.|....:|:.||:|||||||||||||.|.||||||:|||||||||||||||||||||
Zfish   520 NVTMGYYRTEGCNNDDFFVDQNGQRWFCTGDIGEMHADGCLQIVDRKKDLVKLQAGEYVSLGKVE 584

Human   590 AALKNCPLIDNICAFAKSDQSYVISFVVPNQKRLTLLAQQKGVEGTWVDICNNPAMEAEILKEIR 654
            :|||||..:|||||:|.|||:|||||:|||||:||.||.|||:||||.:|||:|.||.|:|:||:
Zfish   585 SALKNCSFVDNICAYANSDQNYVISFIVPNQKKLTALANQKGIEGTWEEICNHPVMEREVLREIK 649

Human   655 EAANAMKLERFEIPIKVRLSPEPWTPETGLVTDAFKLKRKELRNHYLKDIERMYGGK 711
            |.||::||:|||||:.|.||||||||||||||||||||||||:||||.|||||||.|
Zfish   650 EVANSIKLQRFEIPVMVHLSPEPWTPETGLVTDAFKLKRKELKNHYLNDIERMYGHK 706

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACSL4	NP_075266.1	LC_FACS_euk1	121..696	CDD:341294	438/574 (76%)
acsl4a	NP_956943.1	LC_FACS_euk1	117..691	CDD:341294	438/574 (76%)
		PRK04813	<230..>292	CDD:235313	41/61 (67%)