Protein Alignment ACSL4 and lcf1

DIOPT Version :10

• Sequence 1: NP_075266.1
• Gene: ACSL4 / 2182
• HGNCID: 3571
• Length: 711
• Species: Homo sapiens
• Sequence 2: NP_595726.1
• Gene: lcf1 / 2540731
• PomBaseID: SPBC18H10.02
• Length: 676
• Species: Schizosaccharomyces pombe
• Alignment Length: 697
• Identity: 221/697 - (31%)
• Similarity: 374/697 - (53%)
• Gaps: 57/697 - (8%)

Human    45 RIKAKPTSDKP----GSPYRSVTHFDSLAVIDIPGADTLDKLFDHAVSKFGKKDSLGTREILSEE 105
            ::::|..| ||    .:.||:....|.|.........||..:|.|:|.:||.|.::|.|.::.|.
pombe     2 KVQSKAIS-KPKEHESAIYRNANFPDHLVETYSDDVHTLFDVFRHSVKQFGNKKAMGYRNLVKEH 65

Human   106 NEMQPNGKVF---KKLI--------LGNYKWMNYLEVNRRVNNFGSGLTALGLKPKNTIAIFCET 159
            .|.:...||.   ||.:        |.:|.::::.::..:...:...|..|||...:...::..|
pombe    66 VETKMVTKVVDGEKKEVPKSWSYFELSDYNYLSFNDIYDKALRYAGALRKLGLNKGDKFELYAPT 130

Human   160 RAEWMIAAQTCFKYNFPLVTLYATLGKEAVVHGLNESEASYLITSVELLESKLKTALLDISCVKH 224
            .|.|::.|:.|...:..:||.|.|||:|.::|.|.||....:.|...||:: |...|.:|..::.
pombe   131 SAFWLLTAEACLSQSMTIVTAYDTLGEEGLLHSLRESGVRGMYTEGHLLKT-LVNPLKEIESLEV 194

Human   225 IIYVDNKAINKAEYPEGFEIHSMQSVEELGSNP--------ENLGIP--PSRPTPSDMAIVMYTS 279
            |||.::.   |.|        .:::::|:..|.        |.:..|  |..|:|.::..:||||
pombe   195 IIYRNDA---KEE--------DIKTIQEIRPNLKLIKFADFEKMSPPVEPDPPSPEEICCIMYTS 248

Human   280 GSTGRPKGVMMHHSNLIAGMTGQCERIPGLGPKDTYIGYLPLAHVLELTAEISCFTYGCRIGYSS 344
            ||||.||||::.|.|::|.:|...:.:|.:..||..:.||||||:||...|..|..:|..|||::
pombe   249 GSTGLPKGVILSHKNMVAIVTAIVKHVPEVTSKDYLLAYLPLAHILEFAFENICLAWGGTIGYAN 313

Human   345 PLTLSDQSSKIKKGSKGDCTVLKPTLMAAVPEIMDRIYKNVMSKVQEMNYIQKTLFKIGYDYKLE 409
            ..||.|.:.   :..|||....:||:|..||.:.:.:.|.:|||:...:.:::::|...|..|.:
pombe   314 VRTLVDTNC---RNCKGDINTFRPTIMVGVPAVWEMVRKGIMSKLNAASAVKRSVFWTAYYTKAK 375

Human   410 QIKKGYDAP---LCNLLLFKKVKAL-LGGNVRMMLSGGAPLSPQTHRFMNVCFCCPIGQGYGLTE 470
            .::  ::.|   :.:..:|.|:::: .||.:|..||||:.|||.|.||:::.. ||:..||||||
pombe   376 LMR--HNLPGSCVLDTAVFNKIRSMGTGGRLRYTLSGGSALSPDTKRFLSIVL-CPMLIGYGLTE 437

Human   471 SCGAGTVTEVTDYT-TGRVGAPLICCEIKLKDWQEGGYTINDKPNPRGEIVIGGQNISMGYFKNE 534
            ...|..|.....:. ....|:.|.|.|:||.|.:||.|..:..| |||||.:.|.:::.||...:
pombe   438 ISAAAMVQNPACFNLDDSAGSLLPCTEMKLVDCEEGNYNSHGHP-PRGEIWLRGPSLTRGYLNRD 501

Human   535 EKTAEDYSVDENGQRWFCTGDIGEFHPDGCLQIIDRKKDLVKLQAGEYVSLGKVEAALKNCPLID 599
            ::..|.::.|    .||.|||:||..|:|.|:||||||:|||.|.|||::|.|:|:..:...|:.
pombe   502 KENKESFTPD----GWFRTGDVGELTPEGLLRIIDRKKNLVKTQNGEYIALEKLESRYRTSSLVS 562

Human   600 NICAFAKSDQSYVISFVVPNQKRLTLLA-QQKGV--EGTWVDICNNPAMEAEILKEIREAANAMK 661
            |||.:|...:...::.:|||:..:..|| :|.|:  :.:|.::|:|..:...:..::.....:..
pombe   563 NICVYADQTKVKPLAIIVPNEPVVRKLATEQAGLSPDASWEEVCHNKKVRQLVYDDLIRIGRSHH 627

Human   662 LERFEIPIKVRLSPEPWTPETGLVTDAFKLKRKELRNHYLKDIERMY 708
            ....|:...|.|.|..:|||.||||.|.||:|:::.:.:.|:|:..|
pombe   628 FANIELIQNVVLVPIEFTPENGLVTAAQKLQRRKILDRFKKEIDAAY 674

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACSL4	NP_075266.1	LC_FACS_euk1	121..696	CDD:341294	193/592 (33%)
lcf1	NP_595726.1	LC_FACS_euk1	92..662	CDD:341294	193/592 (33%)