Protein Alignment ACSL4 and acs-17

DIOPT Version :10

• Sequence 1: NP_075266.1
• Gene: ACSL4 / 2182
• HGNCID: 3571
• Length: 711
• Species: Homo sapiens
• Sequence 2: NP_001360705.1
• Gene: acs-17 / 180859
• WormBaseID: WBGene00016716
• Length: 721
• Species: Caenorhabditis elegans
• Alignment Length: 721
• Identity: 326/721 - (45%)
• Similarity: 470/721 - (65%)
• Gaps: 20/721 - (2%)

Human     1 MKLKLN------VLTIILLPVHLLITIYSALIFIPWYFLTNAKKKNAMAKRIKAKPTSDKPGSPY 59
            :|..||      .:|:.::.:.::..||..:.|||:....:..:|...::|:||:|.:..|.:|:
 Worm     7 VKSALNGHDRPFTITLAIVLLKIVFFIYDVVTFIPFKIFADPAEKLEKSERVKAEPDNGDPTTPW 71

Human    60 RSVTHFDSLAVIDIPGADTLDKLFDHAVSKFGKKDSLGTREILSEENEMQPNGKVFKKLILGNYK 124
            ::|:..|.|......|...|...::..|.::|.:..:||||:|....|.|.|||:|:|..:|:|.
 Worm    72 KNVSAKDGLMNSSFEGIHDLGTQWEECVRRYGNQPCMGTREVLKVHKEKQSNGKIFEKWQMGDYH 136

Human   125 WMNYLEVNRRVNNFGSGLTALGLKPKNTIAIFCETRAEWMIAAQTCFKYNFPLVTLYATLGKEAV 189
            |.:|.:|::|||...||||:||.:.|..|.:|.|||.|||..|..|.|.|||:.|:|||||.|||
 Worm   137 WRSYAQVDKRVNMIASGLTSLGQQEKEPIILFAETREEWMTTALACMKMNFPIATMYATLGDEAV 201

Human   190 VHGLNESEASYLITSVELLESKLKTALLD-ISCVKHIIYVDNKAINKAEYPEGFEI---HSMQSV 250
            ...:||..|..:.|| |.|.||:|.|:.: .:.:::||:.|  :::.|...|..::   .::.|.
 Worm   202 QFAINEVGAKTIFTS-EALISKVKKAMSNGATSIENIIFFD--SVDPASRGESVDVDLPFTLLSF 263

Human   251 EELGSNPE-NLGIP-PSRPTPSDMAIVMYTSGSTGRPKGVMMHHSNLIAGMTGQCERIPGLGPKD 313
            ::|.|..| ....| |:|....|:|.:|||||:||.|||||:.|.|::|...||...|. |||.|
 Worm   264 DQLLSRGEREYSYPVPTRSKKDDLAFIMYTSGTTGNPKGVMISHQNIVAVTAGQAFNIV-LGPDD 327

Human   314 TYIGYLPLAHVLELTAEISCFTYGCRIGYSSPLTLSDQSSKIKKGSKGDCTVLKPTLMAAVPEIM 378
            .|||||||||:||:.||:..||.|.||||||..||.|::.||.||..|||.||:|||||.||.:|
 Worm   328 RYIGYLPLAHILEVCAEMVVFTKGVRIGYSSAQTLFDRAPKIMKGEHGDCWVLQPTLMACVPAVM 392

Human   379 DRIYKNVMSKVQEMNYIQKTLFKIGYDYKLEQIKKGYDAPLCNLLLFKKVKALLGGNVRMMLSGG 443
            |||:|.|:.:|...:.:.|.|||..|:.|..:.::||.:.:.|.|:|.::..||||.||.:||||
 Worm   393 DRIFKAVIDEVNANSELFKQLFKTCYERKRSRYEEGYTSFILNKLVFNRIGKLLGGKVRQILSGG 457

Human   444 APLSPQTHRFMNVCFCCPIGQGYGLTESCGAGTVTEVTDYTTGRVGAPLICCEIKLKDWQEGGYT 508
            |||||:|.||||:|||||:.|||||||:||.||:.::.|.:||.||.||.||||.|::|.|.||:
 Worm   458 APLSPETQRFMNICFCCPVVQGYGLTETCGGGTIADIHDLSTGTVGPPLTCCEILLQEWAEAGYS 522

Human   509 INDKPNPRGEIVIGGQNISMGYFKNEEKTAEDYSVDENGQRWFCTGDIGEFHPDGCLQIIDRKKD 573
            ..:.| |:|||:|.|.|:::|||||:|||.|:: |..||:.:|.|||||||..||.|:|||||||
 Worm   523 PKNDP-PQGEILISGPNVALGYFKNDEKTKEEF-VKVNGKTFFATGDIGEFREDGSLKIIDRKKD 585

Human   574 LVKLQAGEYVSLGKVEAALKNCPLIDNICAFAKSDQSYVISFVVPNQKRLTLLAQQKGVEG-TWV 637
            |:||..|||:||||||..|...|.:||:|.:..|::|::::.||||||.||.||.:.|... .:.
 Worm   586 LLKLAHGEYISLGKVETNLLTNPNVDNVCVYGDSNKSFLVALVVPNQKNLTQLASKAGASNDNFE 650

Human   638 DICNNPAMEAEILKEIREAANAMKLERFEIPIKVRLSPEPWTPETGLVTDAFKLKRKELRNHYLK 702
            .:|.:..:...:.||:.: ..|.||:|.|||.|:.:..|||||.:||:|:|.|||||.:...:.|
 Worm   651 KLCEDKKVVEALQKELAQ-YGASKLQRVEIPQKIFICHEPWTPASGLLTEALKLKRKNIEKAFRK 714

Human   703 DIERMY 708
            :::.:|
 Worm   715 ELDELY 720

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACSL4	NP_075266.1	LC_FACS_euk1	121..696	CDD:341294	289/581 (50%)
acs-17	NP_001360705.1	LC_FACS_euk1	133..708	CDD:341294	289/581 (50%)