DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tgm3 and Tg

DIOPT Version :9

Sequence 1:	XP_006499214.1	Gene:	Tgm3 / 21818	MGIID:	98732	Length:	704	Species:	Mus musculus
Sequence 2:	NP_609174.1	Gene:	Tg / 34093	FlyBaseID:	FBgn0031975	Length:	776	Species:	Drosophila melanogaster

Alignment Length:	715	Identity:	246/715 - (34%)
Similarity:	376/715 - (52%)	Gaps:	50/715 - (6%)

- Green bases have known domain annotations that are detailed below.

Mouse     2 VVRSKRTDPDAEA-LQIQNVNWQVPMNRRAHHTDKF----SSQDSIVRRGQPWEIILVCNRSLES 61
            :.:..:||..:.| |.:..|:..:..|...|||..|    :.:..:||||:|:.:.:..||....
  Fly    40 IPQGDKTDGASSAVLGVLKVDLCLEDNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHFNRDYSP 104

Mouse    62 GED-LNFIVS----TGPQPSESARTKAVFSISG----RSTGGWNAALKANSGNNLAIAIASPVSA 117
            .:| ::||.:    |.|.|.... ..|:....|    ..|..|.|.::::.|..|.:.|..|.:.
  Fly   105 SKDAISFIFTVADDTKPSPGHGT-LNALVPHDGIDYLGDTLEWGAGIESHEGQTLTVLIKPPSTC 168

Mouse   118 PIGLYTLSVEISSRG---RASSLKLGTFIMLFNPWLQADDVFMSNHAERQEYVEEDSGIIYVGST 179
            |:..:.|.::....|   |:..|.|..:: |||||...|.|::.:..:|:|||..|:.:|:.||.
  Fly   169 PVTEWKLDIDTKLLGDGSRSYPLPLPIYV-LFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGSY 232

Mouse   180 NRIGMVGWNFGQFEEDILNISLSILDRSLNFRRDPVTDVARRNDPKYVCRVLSAMINGNDDNGVI 244
            ||:....|..||||..:|..||.:|.   ...|.|   .|.|.||..|.|.|||::|..||:||:
  Fly   233 NRLRPSVWKIGQFERHVLECSLKVLG---TVGRIP---PAYRGDPVRVARALSALVNSVDDDGVL 291

Mouse   245 SGNWSGNYTGGVDPRTWNGSVEILKNWKKSGFRPVQFGQCWVFAGTLNTVLRCLGVPSRVITNFN 309
            .||||.:::|||.|..|.||||||:.:.|:. :.|:|.|||.|:|.|.|:.|.||:|||:||.::
  Fly   292 LGNWSEDFSGGVAPTKWTGSVEILQQFYKTQ-KSVKFAQCWNFSGVLTTIARSLGIPSRIITCYS 355

Mouse   310 SAHDTDRNLSVDVYYDAMGNPLE-KGSDSVWNFHVWNEGWFVRTDLG----PTYNGWQVLDATPQ 369
            |||||..:|:|||:.||....|: :.:||:||:|||||.|..|.|||    .|::||||:|||||
  Fly   356 SAHDTQASLTVDVFIDANNKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDATPQ 420

Mouse   370 ERSQGVFQCGPASVNAIKAGDVDRNFDMIFIFAEVNADRITWIYNNRNNTQKQNSVDTHSIGKYI 434
            |.|..:::.|||||.|:|.||:.|.||..|:|||||||::.|.||..:...|....||.:||..|
  Fly   421 EASDNMYRVGPASVAAVKNGDILRPFDGGFVFAEVNADKLYWRYNGPSQPLKLLRKDTLAIGHLI 485

Mouse   435 STKAVGSNSRMDVTDKYKYPEGSSEERQVHQKALDKLKPNASFGATSSRNPEG----EDKEPSIS 495
            |||||....|.|:||.||:.|.|.|||....|||.:           ||:...    .|....|.
  Fly   486 STKAVLKWEREDITDTYKHAERSEEERSTMLKALKQ-----------SRHAFSRYYLNDNFNDIE 539

Mouse   496 GKFKVTGILAVGKEVSLSLMLKNMTNDR-KTVTMNMTAWTIVYNGTLVHEVWKDSATISLDPEEE 559
            ...::...:.:|:..|:.|.:.|.:..| ...|..::...::|.|....||......:.|:|:..
  Fly   540 FDMELKDDIKIGQSFSVVLKVSNKSESRTHMATGQISCDAVLYTGVGAVEVKTLGFELELEPKSS 604

Mouse   560 IQYPVKIAYSQYERYLKADNMIRITAVCKVPD-EAEVVVERDVILDNPALTLEVLEQAHV-RKPV 622
            ....:::.:.:|...|.:....:|:|..||.| :.:...:.|..:..|.:..::.|.|.| :|.:
  Fly   605 DYVRMEVIFEEYYDKLSSQAAFQISAAAKVKDTDYDYYAQDDFRVRKPDIKFQLGEAAIVAQKEL 669

Mouse   623 NVQMLFSNPLDQPVNNCVLLVEGSGLLRGSLKIDVPSLRPKEKSRIRFEIFPTRSGTKQLLADFS 687
            :|.:...|||..|::..|..|||.| :...||..:..:.....:...|:..|..:|...:||.|:
  Fly   670 DVILRLENPLPIPLHKGVFTVEGPG-IEQPLKFKIAEIPVGGTAAATFKYTPPYAGRGTMLAKFT 733

Mouse 688 687
Fly 734 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tgm3	XP_006499214.1	Transglut_N	15..129	CDD:366347	31/126 (25%)
		TGc	276..368	CDD:214673	50/96 (52%)
		Transglut_C	494..599	CDD:366371	20/106 (19%)
		Transglut_C	606..702	CDD:366371	23/83 (28%)
Tg	NP_609174.1	Transglut_N	56..179	CDD:279240	30/123 (24%)
		TGc	324..419	CDD:214673	50/94 (53%)
		Transglut_C	538..644	CDD:279295	20/105 (19%)
		Transglut_C	652..750	CDD:279295	23/83 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I7154
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11590
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020