DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tgm1 and Tg

DIOPT Version :9

Sequence 1:	NP_001155186.1	Gene:	Tgm1 / 21816	MGIID:	98730	Length:	815	Species:	Mus musculus
Sequence 2:	NP_609174.1	Gene:	Tg / 34093	FlyBaseID:	FBgn0031975	Length:	776	Species:	Drosophila melanogaster

Alignment Length:	771	Identity:	281/771 - (36%)
Similarity:	410/771 - (53%)	Gaps:	60/771 - (7%)

- Green bases have known domain annotations that are detailed below.

Mouse    50 CCGCCSCGNRGDDDW----GPEPSGSRSRGTSSRGRDSRGGRRPESRGSGVNAAGDGT--IREGM 108
            ||..|     ||..|    ..|.|..|.|..::            :..:|: ..||.|  ....:
  Fly     7 CCQKC-----GDWKWCTSKDNEESTLRIRNANA------------NYFTGI-PQGDKTDGASSAV 53

Mouse   109 LVVTGVDLLCSRSDQNRREHHTDEF----EYDELIVRRGQPFHMILFLNREYE-SSDRIALELLI 168
            |.|..|||..   :.|..||||..|    ..:.|:||||:||.:.:..||:|. |.|.|:....:
  Fly    54 LGVLKVDLCL---EDNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHFNRDYSPSKDAISFIFTV 115

Mouse   169 G--SNPEVGKGT-HVIIPVG----KGGSGGWKAQVTKNNGHNLNLRVHTSPNAIIGKFQFTVRTR 226
            .  :.|..|.|| :.::|..    .|.:..|.|.:..:.|..|.:.:.......:.:::..:.|:
  Fly   116 ADDTKPSPGHGTLNALVPHDGIDYLGDTLEWGAGIESHEGQTLTVLIKPPSTCPVTEWKLDIDTK 180

Mouse   227 ---SEAGEFQLPFDPRNEIYILFNPWCPEDIVYVDHEDWRQEYVLNESGRIYYGTEAQIGERTWN 288
               ..:..:.||.    .||:|||||||:|.||::..|.|:|||::::..|:.|:..::....|.
  Fly   181 LLGDGSRSYPLPL----PIYVLFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGSYNRLRPSVWK 241

Mouse   289 YGQFDHGVLDACLYILDRRG-MPYGGRGDPVSVSRVVSAMVNSLDDNGVLIGNWTGDYSRGTNPS 352
            .|||:..||:..|.:|...| :|...|||||.|:|.:||:|||:||:|||:|||:.|:|.|..|:
  Fly   242 IGQFERHVLECSLKVLGTVGRIPPAYRGDPVRVARALSALVNSVDDDGVLLGNWSEDFSGGVAPT 306

Mouse   353 AWVGSVEILLSYLRTGYSVPYGQCWVFAGVTTTVLRCLGFATRTVTNFNSAHDTDTSLTMDIYFD 417
            .|.||||||..:.:|..||.:.|||.|:||.||:.|.||..:|.:|.::|||||..|||:|::.|
  Fly   307 KWTGSVEILQQFYKTQKSVKFAQCWNFSGVLTTIARSLGIPSRIITCYSSAHDTQASLTVDVFID 371

Mouse   418 ENMKPLEHLNHDSVWNFHVWNDCWMKRPDLPSG----FDGWQVVDATPQETSSGIFCCGPCSVES 478
            .|.|.|:....||:||:||||:.||:||||..|    |||||||||||||.|..::..||.||.:
  Fly   372 ANNKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDATPQEASDNMYRVGPASVAA 436

Mouse   479 VKNGLVYMKYDTPFIFAEVNSDKVYWQRQDDGS-FKIVYVEEKAIGTLIVTKAIHSNNREDITHI 542
            ||||.:...:|..|:|||||:||:||:...... .|::..:..|||.||.|||:....|||||..
  Fly   437 VKNGDILRPFDGGFVFAEVNADKLYWRYNGPSQPLKLLRKDTLAIGHLISTKAVLKWEREDITDT 501

Mouse   543 YKHPEGSEAERRAVEKAAAHGSKP-NVYATRDSAEDVAMQVEAQDAV-MGQDLAVSVVLTNRGSS 605
            |||.|.||.||..:.||....... :.|...|:..|:...:|.:|.: :||..:|.:.::|:..|
  Fly   502 YKHAERSEEERSTMLKALKQSRHAFSRYYLNDNFNDIEFDMELKDDIKIGQSFSVVLKVSNKSES 566

Mouse   606 RRTVKLHLYLC-VTYYTGVSGPTFKEAKKEVTLAPGASDSVTMPVAYKEYKPHLVDQGAMLLNVS 669
            |..:......| ...||||.....|....|:.|.|.:||.|.|.|.::||...|..|.|..::.:
  Fly   567 RTHMATGQISCDAVLYTGVGAVEVKTLGFELELEPKSSDYVRMEVIFEEYYDKLSSQAAFQISAA 631

Mouse   670 GHVKESGQVLAKQHTFRLRTPDLSLTLLGAAVVGQ-ECGVQIVFKNPLPVTLTNVVFRLEGSGLQ 733
            ..||::......|..||:|.||:...|..||:|.| |..|.:..:||||:.|...||.:||.|::
  Fly   632 AKVKDTDYDYYAQDDFRVRKPDIKFQLGEAAIVAQKELDVILRLENPLPIPLHKGVFTVEGPGIE 696

Mouse   734 RPKVLNVGDI--GGNETVTLRQTFVPVRPGPRQLIASLDSPQLSQVHGVIQVDVAP 787
            :|....:.:|  ||....|.:.|  |...|...::|...|.:|..|.|....::.|
  Fly   697 QPLKFKIAEIPVGGTAAATFKYT--PPYAGRGTMLAKFTSKELDDVDGYRHYEIEP 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tgm1	NP_001155186.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..48
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	62..101		6/42 (14%)
		Transglut_N	109..226	CDD:366347	34/128 (27%)
		TGc	370..461	CDD:214673	52/94 (55%)
		Transglut_C	578..682	CDD:366371	29/105 (28%)
		Transglut_C	690..787	CDD:366371	32/99 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	791..815
Tg	NP_609174.1	Transglut_N	56..179	CDD:279240	33/125 (26%)
		TGc	324..419	CDD:214673	52/94 (55%)
		Transglut_C	538..644	CDD:279295	29/105 (28%)
		Transglut_C	652..750	CDD:279295	32/99 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850844
Domainoid	1	1.000	129	1.000	Domainoid score	I5238
eggNOG	1	0.900	-	-		E1_2CD5G
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H306
Inparanoid	1	1.050	451	1.000	Inparanoid score	I1596
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153729at33208
OrthoFinder	1	1.000	-	-		FOG0001456
OrthoInspector	1	1.000	-	-		otm43770
orthoMCL	1	0.900	-	-		OOG6_102867
Panther	1	1.100	-	-	O	PTHR11590
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5185
SonicParanoid	1	1.000	-	-		X1344
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.790