Protein Alignment ACSL3 and Acsx3

DIOPT Version :10

• Sequence 1: NP_004448.2
• Gene: ACSL3 / 2181
• HGNCID: 3570
• Length: 720
• Species: Homo sapiens
• Sequence 2: NP_650831.1
• Gene: Acsx3 / 42354
• FlyBaseID: FBgn0038733
• Length: 538
• Species: Drosophila melanogaster
• Alignment Length: 575
• Identity: 123/575 - (21%)
• Similarity: 202/575 - (35%)
• Gaps: 163/575 - (28%)

Human   115 DEVQPNGKIFKKVILGQYNWLSYEDVFVRAFNFGNGLQMLGQKPKTNIAIFCETRAEWMIAAQAC 179
            :|::.:.::..::...:...|:..::...|.:..:.::.||......:.|...........|.||
  Fly    37 NEMRRHPQLIAQISATENTILTRAELQANAMHIASYMRSLGLLQMDIVGIIARNTTHISAVAYAC 101

Human   180 FMYNFQLVTLYATLGGPAIVHALNETEVTNIITSKELLQTKLKDIVSLV-PRLRHIITVDGKPPT 243
            |            ..|.|. |:||        .|.|  |:.::.:.|:. |   :||..||
  Fly   102 F------------FNGIAF-HSLN--------ISYE--QSTIEKLFSITRP---NIIFCDG---- 136

Human   244 WSEFPKGIIVHTMAAVEALGAK-ASMENQPH---------SKPLPSDI------------AVIMY 286
             .||.|     ..:|...|..| .:|.|.|.         |.|:..:.            ..|:.
  Fly   137 -DEFEK-----VRSATAQLDVKIITMRNHPSGSIRIDQVLSTPIEKNFQPVRLEQGNDQTLAILC 195

Human   287 TSGSTGLPKGVMISHSNIIAGITGMAERIPELGEEDVYIGYLPLAHVLELSAELVCLSHGCRIGY 351
            :||:||:||.|.|::|..|...:      ..|...||...:..|..:..|   |..::.|.   :
  Fly   196 SSGTTGIPKAVTITNSRQILNSS------HSLTTNDVQYSHSTLDWITGL---LTTVTSGV---F 248

Human   352 SSPQTLADQSSKIKKGSKGDTSMLKPTLMAAVPEIMDRIYKNVMNKVSEMSSFQRNLFILAYNYK 416
            |:.:.:||....                    ||...|:          :...|....|.|..:.
  Fly   249 STKRIIADNIFD--------------------PEFFMRL----------VEEHQITWIIQAPAHM 283

Human   417 MEQISKGRNTPLCDSFVFRKVRSLLGGNIRLLLCGGAPLSATTQ-----RFMNICFCCPVGQGYG 476
            ...:    |:|   ||....:.||     |..|.||:..|..||     |....|    :...||
  Fly   284 AMMV----NSP---SFTTSDLSSL-----RYYLFGGSRASVETQHRIRSRLSKDC----LHFAYG 332

Human   477 LTESAGAGTISEVWDYNTGRVGAPLVCCEIKLK-NWEEGGYFNTDKPHPRGEILIGGQSVTMGYY 540
            .||......::..:|.....||.  :...:||| ..|:|.....|:.   ||:.:.......|||
  Fly   333 FTELGSMAALNLHFDEKPNSVGR--LVAGLKLKVICEKGESLGPDEV---GELCLWNGQYWAGYY 392

Human   541 KNEAKTKADFFEDENGQRWLCTGDIGEFEPDGCLKIIDRKKDLVKLQAGEYVSLGKVEAALKNLP 605
            .|..:|    .:..:...|..|||:|..:.||.:.|::||||::|.|...|.. .::|:.:..:|
  Fly   393 GNPEET----HKMRDHHNWFHTGDLGYVDDDGFIYIVERKKDMLKFQNIMYYP-NEIESVISKMP 452

Human   606 LVDNICAYANSYHSYVIGFVVPNQKELTELARKKGLKGTWEELCNSCEMENEVLK 660
            .|..:|.:                             |.|.|: |..|....|:|
  Fly   453 DVVEVCVF-----------------------------GVWNEI-NGDEATAAVVK 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACSL3	NP_004448.2	Adenylate forming domain, Class I superfamily	30..717	CDD:473059	123/575 (21%)
Acsx3	NP_650831.1	Firefly_Luc_like	47..522	CDD:341237	122/565 (22%)