DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACSL3 and CG3961

DIOPT Version :9

Sequence 1:	NP_001341087.1	Gene:	ACSL3 / 2181	HGNCID:	3570	Length:	720	Species:	Homo sapiens
Sequence 2:	NP_649067.2	Gene:	CG3961 / 40056	FlyBaseID:	FBgn0036821	Length:	704	Species:	Drosophila melanogaster

Alignment Length:	729	Identity:	231/729 - (31%)
Similarity:	363/729 - (49%)	Gaps:	93/729 - (12%)

- Green bases have known domain annotations that are detailed below.

Human    25 FIHFL------ISLYTILTYIPFYFFSESRQEK-----SNRIKAKPVNSKPDSAYRS---VNSLD 75
            ::::|      ::|.::...:.:||.:....|:     .|:   .|:...|:..:.|   ..|.:
  Fly    29 YLYYLGGTLGTLTLGSLAASVAYYFATRPVPERPLVPLENQ---SPLLEGPEQIHVSKFYKESKN 90

Human    76 G-LASVLYPGCDTLDKVF---TYAKNKFKNKRLLGTREVLNEEDEVQPNGKIFKKVILGQYNWLS 136
            | ..|.:.....||.:.|   .||.|   |...||.||.|.                 ..|.|::
  Fly    91 GKFVSYITENVRTLYQTFREGAYASN---NGPCLGWRETLT-----------------SPYQWIN 135

Human   137 YEDVFVRAFNFGNGLQMLGQKPKTNIAIFCETRAEWMIAAQACFMYNFQLVTLYATLGGPAIVHA 201
            |::..:||.|||.|:..||.:||..|.|:.:.|.||::..|.|:.::..:|.||.|||..|....
  Fly   136 YDEALLRAKNFGAGMLALGARPKQLIGIYSQNRPEWILYEQGCYSFSLVVVPLYDTLGPDACAFI 200

Human   202 LNETEVTNIITSKE-----LLQ---TKLKDIVSLVPRLRHIITVDGKPPTWSEFPKGIIVHTMAA 258
            :.:|::..:|...:     ||:   ..||.||::.| :|.......:       .:||.:.:...
  Fly   201 IRQTDMQVVIVEDDGKAAMLLEKAPRSLKIIVAIKP-IRQTTLERAR-------SRGIQIFSFID 257

Human   259 VEALGAKASMENQPHSKPLPSDIAVIMYTSGSTGLPKGVMISHSNIIAGITGMAERIPELGEE-- 321
            ||.||||.   |.|...|...|:..:.||||:||.|||||::|.|::||:..:   |.::|:.
  Fly   258 VEKLGAKG---NHPEVPPTAEDLCTVCYTSGTTGNPKGVMLTHGNVVAGVCSV---ILQMGDHRI 316

Human   322 ---DVYIGYLPLAHVLELSAELVCLSHGCRIGYSSPQTLADQSSKIKKGSKGDTSMLKPTLMAAV 383
               ||.:.:|||||:.|...|......|..:|:        .|..||: ...|..|||||:|.||
  Fly   317 RAGDVMVSFLPLAHMFERCCENGMYYVGGCVGF--------YSGDIKE-LTNDLKMLKPTVMPAV 372

Human   384 PEIMDRIYKNVMNKVSEMSSFQRNLFILAYNYKMEQISKG--RNTPLCDSFVFRKVRSLLGGNIR 446
            |.:::|:|..:.|.:| .|..:|.||.:|...|.::|::|  |.....|..||:||....|||:|
  Fly   373 PRLLNRVYDKIQNDIS-ASGLKRGLFNMAMRAKEKEIARGVLRRNGCWDKLVFKKVHQAFGGNLR 436

Human   447 LLLCGGAPLSATTQRFMNICFCCPVGQGYGLTESAGAGTISEVWDYNTGRVGAPLVCCEIKLKNW 511
            |::.|.|||:.....||.....|.|.:|||.||..||.|::...|:....||.|:.|..:||.:.
  Fly   437 LMVVGSAPLAGNVLTFMRCALGCLVLEGYGQTECTGAITLTVQGDHVPNHVGPPVSCNAVKLVDV 501

Human   512 EEGGYF---NTDKPHPRGEILIGGQSVTMGYYKNEAKTKADFFEDENGQRWLCTGDIGEFEPDGC 573
            .|..||   ||      ||:.:.|.:|..||||:..|| |:..:.|.   |..|||:|.:.|:|.
  Fly   502 PEMEYFANQNT------GEVCVRGSNVFHGYYKDPEKT-AEAIDSEG---WHHTGDVGMWLPNGT 556

Human   574 LKIIDRKKDLVKLQAGEYVSLGKVEAALKNLPLVDNICAYANSYHSYVIGFVVPNQKELTELARK 638
            |:||||:|.:.||..|||:...|:|........|:.:..|..|..|.:|..|||:...|.:.|.:
  Fly   557 LRIIDRRKHIFKLSQGEYIVPEKIENIYTLSQYVNQVYVYGESLKSCIIAVVVPDTDVLKQWATE 621

Human   639 KGLKGTWEELCNSCEMENEVLKVLSEAAISASLEKFEIPVKIRLSPEPWTPETGLVTDAFKLKRK 703
            ..::||...|||:..::..::..:......:.|:.||....|.|.|:|::.:.||:|..||.||.
  Fly   622 NNVRGTLSVLCNNKNVKELIMNDMLNWGKQSGLKSFEQVKDIYLHPDPFSVQNGLLTPTFKAKRP 686

Human   704 ELKTHYQADIERMY 717
            :||::::..:|.||
  Fly   687 QLKSYFKPQLEDMY 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACSL3	NP_001341087.1	AFD_class_I	30..717	CDD:418409	228/716 (32%)
CG3961	NP_649067.2	LC-FACS_euk	130..701	CDD:341250	207/605 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1022
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53493
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820