Protein Alignment ACSL3 and Fatp2

DIOPT Version :10

• Sequence 1: NP_004448.2
• Gene: ACSL3 / 2181
• HGNCID: 3570
• Length: 720
• Species: Homo sapiens
• Sequence 2: NP_995925.2
• Gene: Fatp2 / 37657
• FlyBaseID: FBgn0265187
• Length: 714
• Species: Drosophila melanogaster
• Alignment Length: 687
• Identity: 158/687 - (22%)
• Similarity: 256/687 - (37%)
• Gaps: 178/687 - (25%)

Human    77 LASVLYPGCDTLDKVFTYAK----NKFKNKRLLGTREVLNEEDEVQPNGKIFKKVILGQYNWLSY 137
            :|:|..|. ||: .:|.|.:    .|.:.::.|...::.......||:    |..|:.:....::
  Fly   109 IAAVTTPR-DTV-ALFAYIRVLLFIKRQERKNLNIGDIFESNVARQPD----KLAIVSESQQWTF 167

Human   138 EDVFVRAFNFGNGLQMLGQKPKTNIAIFCETRAEWMIAAQACFMYNFQLVT--LYATLGGPAIVH 200
            ..|...:....|.....|.|....:.:..|.|||::  |....:....::|  :...|.|.::.|
  Fly   168 RQVNEHSNRVANVFHSHGYKKGDVVGLLLENRAEFV--ATWLGLSKIGVITPLINTNLRGASLQH 230

Human   201 ALNETEVTNIITSKELLQTKLKDIVSLVP-----------RLRHIITVDGKPPTWSEFPKGIIVH 254
            ::...:.|.:|.... .::.:.||...:|           ..:.::..:|.....::...|::
  Fly   231 SITVGQCTALIYGAS-FRSAVMDIAKDLPAHVGLYQFNDESNQEVVASEGLSQGLAQQLNGLL-- 292

Human   255 TMAAVEALGAKASMENQPHSKPLPSDIAVIMYTSGSTGLPKGVMISHSN---IIAGITGMAERIP 316
            ..||.:.:.|.||..:. |.|      .|.:||||:|||||..:|:||.   |.|||.      .
  Fly   293 ETAAKDKVAAGASRADH-HDK------LVYIYTSGTTGLPKAAVITHSRYFFIAAGIH------Y 344

Human   317 ELG--EEDVYIGYLPLAHVLELSAELVCLSHGCRIGYSSPQTLADQSSKIKKGSKGDTSMLKPTL 379
            .||  ::||:...|||.|    :|..| :|.|..:.:.|...:..:.|  ..|...|.:..:.|
  Fly   345 TLGFKDQDVFYTPLPLYH----TAGGV-MSMGQALLFGSTVVIRKKFS--ASGYFSDCARFQCT- 401

Human   380 MAAVPEIMDRIYKNVMNKVSEMSSFQRNLFILAYNYKMEQISKGRNTPLCDSFVFRKVRSLLGGN 444
                          |...:.||:.     :|||             ||........:||.:.|..
  Fly   402 --------------VGQYIGEMAR-----YILA-------------TPSAPHDRNHQVRMVFGNG 434

Human   445 IRLLLCGGAPLSATTQRFMNICFCCPVGQGYGLTE----------SAGA-GTISEVW-------- 490
            :|         .....:|:.......||:.||.||          :.|| |.||.:.
  Fly   435 LR---------PQIWPQFVERFGIRKVGEFYGATEGNANIMNNDSTVGAIGFISRILPQIYPISI 490

Human   491 ---DYNTGRVGAPL-----VC--CEIKLKNWEEGGYFNTDKPHPRGEILIGGQ-SVTMGYYKNEA 544
               |.:||.   ||     :|  ||.     :|.|.|       .|:|:.|.. ...:||...:|
  Fly   491 IKADPHTGE---PLRNSQGLCERCEA-----DEPGVF-------VGKIVRGNPCREFLGYVDQKA 540

Human   545 KTKA---DFFEDENGQRWLCTGDIGEFEPDGCLKIIDRKKDLVKLQAGEYVSLGKVEAALKNLPL 606
            .:|.   |.|  ..|.....:||:...:..|.|...||..|..:.: ||.||..:|||.|.||..
  Fly   541 SSKKVVHDVF--SKGDMAFISGDLLVADERGYLYFKDRTGDTFRWK-GENVSTSEVEAQLSNLAG 602

Human   607 VDNICAYANSYHSYVIGFVVPNQKELTELARKKGLKGTWEEL--CNSCEMENEVLKVLSEAAISA 669
            ..::..|         |..:||    ||  .:.|:...::..  .|..::..|:.|.|...|...
  Fly   603 YKDVIVY---------GVSIPN----TE--GRAGMAAIYDPTREVNVSQLGVELAKSLPNYARPQ 652

Human   670 SLEKFEIPVKIRLSPEPWTPETGLVTDAFKLKRKELK 706
            .|....   ||.|            |..|||::.||:
  Fly   653 FLRFLR---KIDL------------TGTFKLRKVELQ 674

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACSL3	NP_004448.2	Adenylate forming domain, Class I superfamily	30..717	CDD:473059	158/687 (23%)
Fatp2	NP_995925.2	Adenylate forming domain, Class I superfamily	163..680	CDD:473059	145/627 (23%)