DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps41 and lt

DIOPT Version :9

Sequence 1:	NP_742118.3	Gene:	Vps41 / 218035	MGIID:	1929215	Length:	853	Species:	Mus musculus
Sequence 2:	NP_001036415.2	Gene:	lt / 3355130	FlyBaseID:	FBgn0002566	Length:	841	Species:	Drosophila melanogaster

Alignment Length:	845	Identity:	318/845 - (37%)
Similarity:	490/845 - (57%)	Gaps:	42/845 - (4%)

- Green bases have known domain annotations that are detailed below.

Mouse    14 ESTDESEEESEEEPKLKYERLSNGVTEILQKDAASCMTVHDKFLALGTHYGKVYLLDVQGN-ITQ 77
            :|..:|..|.:.|||.||.||:|.:..:|..|..:|..||.|||..||..|:|.:.|.||| :..
  Fly    11 DSWADSINEEDVEPKFKYHRLANDLKYMLNADVITCSAVHLKFLIFGTFRGRVCIFDHQGNSVYS 75

Mouse    78 KFDVS-----PVKINQISLDDSGEHMGVCSEDGKLQVFGLYSGEEFHE-TFDCPIKIIAVHPQFV 136
            ....|     .|.:|.|.:|..||::..||:|||:.:.||:|.:..|. :|...||::::.|. .
  Fly    76 NLSASERHTHQVAVNNIDVDHKGEYVATCSDDGKVNITGLFSSDNNHSLSFGKFIKVVSLEPD-S 139

Mouse   137 RSSCKQFVTGGKKLLLFERTWMNRWKSSVLHEGEGNIRSVKWRGHLIAWANNMGVKVFDITSKQR 201
            ::..|:||.|..||:|:||..:.:.|...|...||::.|:.|.|:.||||:::||:|:|:..:..
  Fly   140 KAHIKRFVVGDDKLILYERNLLKKLKPVELCSVEGSVLSICWHGNFIAWASHIGVRVYDLNERCS 204

Mouse   202 IS----NVPRDDISLRPDMYPCSLCWKDNVTLIIGWGTSIKICSVKERHASEMR--DLPSRYVEI 260
            :.    .||..:   |.:.:.|.|.|.:..||:|||..:|::|.:::|::.|..  :||...|:.
  Fly   205 LGLIKWEVPPQE---RLENFRCHLRWSNKHTLLIGWVDTIRVCVIRKRNSIEASTGNLPVYIVDP 266

Mouse   261 VSQFETEFYISGLAPL-CDQLVVLSYVKEVSEKTEREYC---ARPRLDIIQPLPETCEEISSDAL 321
            :|.|:|.||:.||||| ..|||||.:.||.|.      |   .||.|.:|:......|||.:|:|
  Fly   267 ISTFQTTFYVCGLAPLSAKQLVVLGFRKEKSS------CFKALRPVLCVIEYKMNNSEEICTDSL 325

Mouse   322 TVRGFQENECRDYHLEYSEGESLFYVVSPRDVVVAKERDQDDHIDWLLEKKKYEEALMAAEISQR 386
            |:|||:|....||.|.....|:.||:|:|:|:|||...:.||.|:||::..|:|||:   |:...
  Fly   326 TLRGFEEYTVNDYSLGGIIEENRFYIVAPKDIVVASLIETDDRIEWLIKHSKFEEAM---ELISA 387

Mouse   387 NIKRHKILDIGLAYVNHLVERGEYDMAARKCQKILGKNASLWEYEVYKFKEIGQLKAISPYLPRG 451
            |.....:|.:...|:|||:...:||.||:.|.::||.:..|||.||:||.:..||:::|.|||..
  Fly   388 NGGNVPVLSVAKLYINHLLALKKYDDAAKLCLRMLGNDKVLWEEEVFKFVKCQQLRSVSAYLPTS 452

Mouse   452 DPV-LKPLIYEMILHEFLESDYEGFATLIREWPGDLYNNSVIVQAVRDHLKKDSQNKTLLKTLAE 515
            |.. |.|.:|||:|:|||:.|..||..||:|||..||:...::.|:.|:.:|...|: ||::||.
  Fly   453 DECKLDPHVYEMVLYEFLKFDVCGFLNLIKEWPSHLYDGLAVINAIHDNFRKHYANQ-LLESLAL 516

Mouse   516 LYTYDKNYGNALEIYLTLRHKDVFQLIHKHNLFSSIKDKIVLLMDFDSEKAVDMLLDNEDKISIK 580
            ||:|..::.:||.:||.|::|||||||.::.|:..|...|:.|:..|.:.|.::|||.: ||..:
  Fly   517 LYSYQGDFESALRMYLKLQNKDVFQLIRRYELYDVISKLIIPLIQLDRDCAFEILLDKK-KIKTE 580

Mouse   581 KVVEELEDRPELQHVYLHKLFKRDHHKGQRYHEKQISLYAEYDRPNLLPFLRDSTHCPLEKALEI 645
            .||.:||...|..:.||..|.|:|  ....:.:|.|||||.:||..|||||:.|....:::||.|
  Fly   581 IVVHQLEHNQEYLYWYLDSLLKKD--PSNVFQKKLISLYAIFDRNKLLPFLKRSKDYDIQEALVI 643

Mouse   646 CQQRNFVEETVYLLSRMG--NSRSALKMIMEELHDVDKAIEFAKEQDDGELWEDLILYSIDKPPF 708
            |:|.||..|.||||..||  .:..||.:|:..:.|::.||||.||.||.:||..||......|..
  Fly   644 CKQENFYPEIVYLLGCMGGVEASEALNIIIHRIRDIEMAIEFCKEHDDSDLWNALINEFSKHPEI 708

Mouse   709 ITGLLNNIGTHVDPILLIHRIKEGMEIPNLRDSLVKILQDYNLQILLREGCKKILVADSLSLLKK 773
            :|.:|:.|..:..|.:::.:||.|..|||||.||:|:|:.||||..:....::|.:.|...:..:
  Fly   709 VTKVLDGIVDYFSPAVVVGKIKMGQNIPNLRQSLIKMLRHYNLQGEILSSAQQIQLNDYFEIHSE 773

Mouse   774 MHRTQMKGVLVDEENICESCLSPILPTDAAKPFSVVVFHCRHMFHKECLPMPSMNAPAQYCNICS 838
            :..||.:|..|..|.:|..|..|:|.. ....:.::...|.|::||.|:    .....:.||.|:
  Fly   774 IVTTQRRGQQVSYEQLCSLCHRPVLMA-GTHLYCIIRLECGHVYHKPCI----QGELLKNCNECN 833

Mouse 839 838
Fly 834 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps41	NP_742118.3	Interaction with ARL8B. /evidence=ECO:0000250\|UniProtKB:P49754	1..539		208/542 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32		7/17 (41%)
		WD40 repeat	87..131	CDD:293791	17/44 (39%)
		WD40 repeat	174..206	CDD:293791	11/35 (31%)
		CHCR	567..711		60/145 (41%)
		CLH	570..707	CDD:128594	59/138 (43%)
		Clathrin	574..709	CDD:279031	57/136 (42%)
lt	NP_001036415.2	WD40 repeat	33..81	CDD:293791	17/47 (36%)
		WD40	<42..204	CDD:295369	59/162 (36%)
		WD40 repeat	90..123	CDD:293791	13/32 (41%)
		WD40 repeat	130..168	CDD:293791	13/38 (34%)
		CLH	570..707	CDD:128594	59/139 (42%)
		Clathrin	580..708	CDD:279031	55/129 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850251
Domainoid	1	1.000	388	1.000	Domainoid score	I788
eggNOG	1	0.900	-	-		E1_KOG2066
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69165
Inparanoid	1	1.050	548	1.000	Inparanoid score	I1139
Isobase	1	0.950	-	0.919607	Normalized mean entropy	S2845
OMA	1	1.010	-	-		QHG54432
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004492
OrthoInspector	1	1.000	-	-		oto93014
orthoMCL	1	0.900	-	-		OOG6_103391
Panther	1	1.100	-	-	LDO	PTHR12616
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1654
SonicParanoid	1	1.000	-	-		X3779
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740