DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppp2r5d and wdb

DIOPT Version :9

Sequence 1:	NP_001344613.1	Gene:	Ppp2r5d / 21770	MGIID:	2388481	Length:	595	Species:	Mus musculus
Sequence 2:	NP_001368946.1	Gene:	wdb / 43312	FlyBaseID:	FBgn0027492	Length:	709	Species:	Drosophila melanogaster

Alignment Length:	497	Identity:	326/497 - (65%)
Similarity:	385/497 - (77%)	Gaps:	16/497 - (3%)

- Green bases have known domain annotations that are detailed below.

Mouse    16 AKGTAK--PSSSSKDGGGE-NTDEAQPQP--QSQSPSSNKRPSNSTPPPTQLSKIKYSGGPQIVK 75
            |.|.|.  |.:|.|:..|: ||.:...:.  .|..|.|.|..|.     |.:.:|.......:.|
  Fly   146 AGGAADQFPVASVKNKAGKLNTTQTATETAIDSNEPKSEKMSSG-----TFVDRIDPFAKRSLKK 205

Mouse    76 K-ERRQSSFPFNLNKNRELQKLPALK-DSPTQEREELFIQKLRQCCVLFDFVSDPLSDLKCKEVK 138
            | ::.|.|..:..:::.|||:||.|| |..:.|:|||||:|||||||.|||: ||::|||.||:|
  Fly   206 KGKKSQGSSRYRNSQDVELQQLPPLKADCSSLEQEELFIRKLRQCCVSFDFM-DPVTDLKGKEIK 269

Mouse   139 RAGLNEMVEYITHSRDVVTEAIYPEAVTMFSVNLFRTLPPSSNPTGAEFDPEEDEPTLEAAWPHL 203
            ||.||::..||||.|.|:||.:|||.:.|.|.|||||||||.||   :||||||:|||||:||||
  Fly   270 RAALNDLSTYITHGRGVLTEPVYPEIIRMISCNLFRTLPPSENP---DFDPEEDDPTLEASWPHL 331

Mouse   204 QLVYEFFLRFLESPDFQPNIAKKYIDQKFVLALLDLFDSEDPRERDFLKTILHRIYGKFLGLRAY 268
            |||||.|||||||.|||..|.|:.|||||||.||:|||||||||||||||:|||||||||||||:
  Fly   332 QLVYEVFLRFLESQDFQATIGKRVIDQKFVLQLLELFDSEDPRERDFLKTVLHRIYGKFLGLRAF 396

Mouse   269 IRRQINHIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKVFLVRVLLPLHKVKSLSVYH 333
            ||:|||:||.||||||||.||:.||||||||||||||||||.|||.|||:|||||||||.||:||
  Fly   397 IRKQINNIFLRFIYETEHFNGVGELLEILGSIINGFALPLKAEHKQFLVKVLLPLHKVKCLSLYH 461

Mouse   334 PQLAYCVVQFLEKESSLTEPVIVGLLKFWPKTHSPKEVMFLNELEEILDVIEPSEFSKVMEPLFR 398
            .|||||:||||||:..|||||:.|||||||||.|.||||||.|:|||||||:|.:|.|:.|||||
  Fly   462 AQLAYCIVQFLEKDPFLTEPVVRGLLKFWPKTCSQKEVMFLGEIEEILDVIDPPQFVKIQEPLFR 526

Mouse   399 QLAKCVSSPHFQVAERALYYWNNEYIMSLISDNAARILPIMFPALYRNSKSHWNKTIHGLIYNAL 463
            |:|||||||||||||||||.|||||.||||.:|.|.|:|||||||||.||.|||:||..|:||.|
  Fly   527 QIAKCVSSPHFQVAERALYLWNNEYAMSLIEENNAVIMPIMFPALYRISKEHWNQTIVALVYNVL 591

Mouse   464 KLFMEMNQKLFDDCTQQYKAEKQKGRFRMKEREEMWQKIEEL 505
            |.|||||.||||:.|..||||:||.:.|.::|||:|:|:.||
  Fly   592 KTFMEMNSKLFDELTSSYKAERQKEKKRERDREELWKKLHEL 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppp2r5d	NP_001344613.1	B56	49..>115	CDD:332353	22/67 (33%)
Ppp2r5d	NP_001344613.1	B56	101..506	CDD:307642	299/405 (74%)
wdb	NP_001368946.1	B56	235..633	CDD:396263	296/401 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2085
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54502
OrthoDB	1	1.010	-	-		D345293at33208
OrthoFinder	1	1.000	-	-		FOG0000226
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100293
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3
SonicParanoid	1	1.000	-	-		X167
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.760