Protein Alignment FANCD2 and fancd2

DIOPT Version :10

• Sequence 1: NP_149075.2
• Gene: FANCD2 / 2177
• HGNCID: 3585
• Length: 1471
• Species: Homo sapiens
• Sequence 2: NP_958498.1
• Gene: fancd2 / 394241
• ZFINID: ZDB-GENE-040116-5
• Length: 1445
• Species: Danio rerio
• Alignment Length: 1451
• Identity: 782/1451 - (53%)
• Similarity: 1026/1451 - (70%)
• Gaps: 45/1451 - (3%)

Human     1 MVSKRRLSKSEDKESLTEDASKTRKQPLSKKTKKSHIANEVEENDSIFVKLLKISGIILKTGESQ 65
            |:.|::.|.....|..|.|.||.:|...|.::.||.:.:..:  ||:||:.||.||:.|..|.:.
Zfish     1 MMRKKKRSSVTVDEDPTLDVSKAKKSKSSGRSTKSSVQDSCQ--DSVFVQFLKESGVTLTPGSTA 63

Human    66 NQLAVDQIAFQKKLFQTLRRHPSYPKIIEEFVSGLESYIEDEDSFRNCLLSC----ERLQDEEAS 126
            |::||||:.|||:|.|.||:.|.:|.||:||:|.||:||||.:.||||||.|    ...||..:|
Zfish    64 NEIAVDQVIFQKRLQQRLRKSPRFPNIIQEFISALETYIEDPERFRNCLLPCVPAPTSQQDTNSS 128

Human   127 MGASYSKSLIKLLLGIDILQPAIIKTLFEKLPEYFFENKNSDEINIPRLIVSQLKWLDRVVDGKD 191
               ||.:||::|||||::||..:|.||||||||:.||..:.|.:|:|||||:|||||||:|||||
Zfish   129 ---SYQESLVRLLLGIEMLQTLVINTLFEKLPEFMFEGASEDGLNVPRLIVNQLKWLDRIVDGKD 190

Human   192 LTTKIMQLISIAPENLQHDIITSLPEILGDSQHADVGKELSDLLIENTSLTVPILDVLSSLRLDP 256
            |::|:||::|:||..:|.||||||||||.||||.|:.|||:.||.:||.|.|||||.||||.|..
Zfish   191 LSSKLMQMVSVAPVEIQRDIITSLPEILEDSQHGDMAKELNGLLQQNTQLAVPILDALSSLNLSS 255

Human   257 NFLLKVRQLVMDKLSSIRLEDLPVIIKFILHSVTAMDTLEVISELREKLDLQHCVLPSRLQASQV 321
            ..|.:||:.||..||:::||||||::||:|||::|.|..||:.:||:||:|:.||||:.|||||.
Zfish   256 TLLSEVREAVMGTLSAVQLEDLPVVVKFVLHSISASDANEVVCDLRKKLELEQCVLPAVLQASQS 320

Human   322 KLKSKG-RASSSGNQESSGQSCIILLFDVIKSAIRYEKTISEAWIKAIENTASVSEHKVFDLVML 385
            ::|:|. ..|||....||||..:.|:.||||||||::|||||||:|||||.....:|||.||::|
Zfish   321 RMKNKTVSRSSSVPSCSSGQDSVALILDVIKSAIRFQKTISEAWLKAIENIDESEDHKVVDLLVL 385

Human   386 FIIYSTN-TQTKKYIDRVLRNKIRSGCIQEQLLQSTFSVHYLVLKDMCSSILSLAQSLLHSLDQS 449
            ||::||| ..:::..:|||:.|:|.|.|||.|||.||..|..|::....|||:|||.||.|.|..
Zfish   386 FILHSTNANHSRRGAERVLKVKVRKGLIQESLLQKTFKGHAQVMRGYFPSILALAQGLLRSPDCC 450

Human   450 IISFGSLLYKYAFKFFDTYCQQEVVGALVTHICSGNEAEVDTALDVLLELVVLNPSAMMMNAVFV 514
            ::.||..:||.||..||:||||||||:||||.|||...|||.||::|.|||...|:.|....|||
Zfish   451 VVPFGGHMYKQAFTAFDSYCQQEVVGSLVTHACSGVSGEVDVALELLCELVSQKPAEMSQFTVFV 515

Human   515 KGILDYLDNISPQQIRKLFYVLSTLAFSKQNEASSHIQDDMHLVIRKQLSSTVFKYKLIGIIGAV 579
            ||||||:||::.||||:||::||.|||. |.:...|||||||:||||||||||.|||.|||||||
Zfish   516 KGILDYMDNLTSQQIRRLFHLLSRLAFG-QEQHGGHIQDDMHIVIRKQLSSTVPKYKRIGIIGAV 579

Human   580 TMAGIMAADRSESPSLTQERANLSDEQCTQVTSLLQLVHSCSEQSPQASALYYDEFANLIQHEKL 644
            .|.|.|.|.|::...  .:...|..|...||.:||:||.||||.||:|:||.|||.|||:|..||
Zfish   580 MMVGSMGACRNKHDG--SQGGTLPKETNRQVMALLELVRSCSESSPEAAALCYDELANLLQTCKL 642

Human   645 DPKALEWVGHTICNDFQDAFVVDSCVVPEGDFPFPVKALYGLEEYDTQDGIAINLLPLL-FSQDF 708
            ||....|:|.::..||||.||||......|.|.||...||.|:|.:::.|||:|||||: ..|..
Zfish   643 DPLVQAWIGKSVLEDFQDDFVVDLGPDISGAFMFPTSVLYNLDEEESEGGIAVNLLPLMALDQQH 707

Human   709 AKDGGPVTSQESG---QKLVSPLCLAPYFRLLRLCVERQHNGNLEEIDGLLDCPIFLTDLEPGEK 770
            ..|    |||.:|   ::.||||||:|:|||||||.|.||.|:|||||.||.||:.|||:|..||
Zfish   708 KTD----TSQPAGVKRERRVSPLCLSPFFRLLRLCEEVQHEGDLEEIDALLGCPLILTDMEVVEK 768

Human   771 LESMSAKERSFMCSLIFLTLNWFREIVNAFCQETSPEMKGKVLTRLKHIVELQIILEKYLAVTPD 835
            ::|:|..||.|:|||:|.|:|||||:|||||::..||||.||:||:::|..||.:|:..||.||.
Zfish   769 VDSLSKSEREFLCSLLFHTINWFREVVNAFCRQNDPEMKMKVVTRIQNITYLQSLLQTCLAATPG 833

Human   836 YVPPLGNFDVETLDITPHTVTAISAKIRKKGKIE---RKQKTDGSKTSSSDT-----LSEEKNSE 892
            |:||..|||.|:.|:   .:.:.|...:||||.|   ||:|...||.||.|.     .::.:.|:
Zfish   834 YIPPQANFDGESADV---MIPSSSVVQQKKGKKESSGRKRKASASKNSSGDKSQLEGAADAEESQ 895

Human   893 CDPTPSHRGQLNKEFTGKEEKTSLLLHNSHAFFRELDIEVFSILHCGLVTKFILDTEMHTEATEV 957
            .|| |....:..||   |:.|:.:.|.:...||||||:|..|:|.|||:::.:||||:|::..|.
Zfish   896 PDP-PEKESEKEKE---KDGKSGVSLSSYWPFFRELDVEALSVLQCGLLSRTLLDTELHSKLREE 956

Human   958 VQLGPPELLFLLEDLSQKLESMLTPPIARRVPFLKNKGSRNIGFSHLQQRSAQEIVHCVFQLLTP 1022
            |||||.||||||||:.:||:..||...|::.||||.|..:.:||:||||::|:||..|...||..
Zfish   957 VQLGPAELLFLLEDMWRKLDFSLTSAPAKKAPFLKGKMDKAVGFAHLQQKNAKEIATCCSDLLPT 1021

Human  1023 MCNHLENIHNYFQCLAAENHGVVDGPGVKVQEYHIMSSCYQRLLQIFHGLFAWSGFSQPENQNLL 1087
            :|.||||.||:||.|..||.||||.|.|.|:|..:|.|.||.|||:.|.:|:|||||.||::.||
Zfish  1022 LCTHLENCHNHFQTLLTENQGVVDAPNVDVKENQLMCSAYQLLLQVLHTMFSWSGFSIPEHRGLL 1086

Human  1088 YSALHVLSSRLKQGEHSQPLEELLSQSVHYLQNFHQSIPSFQCALYLIRLLMVILEKSTASAQN- 1151
            .|||.:|:.|||:.:....|::|...:..|||||..::||...||.|.:||:|:.:...::.:.
Zfish  1087 KSALGILAGRLKEDQADLTLDQLSRHAFEYLQNFRSTVPSLNTALCLTQLLIVLPQYGGSNHRTY 1151

Human  1152 KEKIASLARQFLCRVW--PSGDKEKSNISNDQLHALLCIYLEHTESILKAIEEIAGVGVPELINS 1214
            :|:|.||.:.|||:.|  .||:||:.|..|:.|..||.||||||:.:|||:|||||.|||||:|:
Zfish  1152 REQITSLTKHFLCQEWVTASGEKERGNKYNETLQTLLSIYLEHTDDVLKAVEEIAGEGVPELLNA 1216

Human  1215 PKDASSSTFPTLTRHTFVVFFRVMMAELEKTVKKIEPGTAADSQQIHEEKLLYWNMAVRDFSILI 1279
            .|||:|.::|||.|.||:|:::.||:||||.|:||.|....|:|::..||||..|:|||||.|||
Zfish  1217 AKDANSRSWPTLNRQTFLVYYKCMMSELEKAVRKIPPSKQMDNQEMQSEKLLTRNLAVRDFHILI 1281

Human  1280 NLIKVFDSHPVLHVCLKYGRLFVEAFLKQCMPLLDFSFRKHREDVLSLLETFQLDTRLLHHLCGH 1344
            ||:|:|||.|||.|||||||||:|:|||..|||||:||:||:|||..||:||||.||.|||:|||
Zfish  1282 NLVKMFDSRPVLTVCLKYGRLFLESFLKLGMPLLDYSFKKHKEDVQGLLKTFQLSTRQLHHMCGH 1346

Human  1345 SKIHQDTRLTQHVPLLKKTLELLVCRVKAMLTLNNCREAFWLGNLKNRDLQGEEIKSQNSQESTA 1409
            |||.|||.||.|||.|||:||..|.|||||||||:|:|||||||||||||:||||.||.||  .|
Zfish  1347 SKIRQDTGLTNHVPALKKSLEQFVYRVKAMLTLNHCQEAFWLGNLKNRDLKGEEILSQRSQ--AA 1409

Human  1410 DESEDDMS---SQASKSKATE 1427
            ||.|::.|   |:|.:|.:.|
Zfish  1410 DEEEEESSQLQSEAEESDSDE 1430

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FANCD2	NP_149075.2	Interaction with FANCE	1..291		157/293 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..37		12/35 (34%)
		FancD2	35..1415	CDD:464225	766/1400 (55%)
		Interaction with BRCA2	248..359		59/111 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	868..906		13/45 (29%)
fancd2	NP_958498.1	FancD2	37..1410	CDD:464225	761/1393 (55%)