Protein Alignment FANCD2 and Fancd2

DIOPT Version :10

• Sequence 1: NP_149075.2
• Gene: FANCD2 / 2177
• HGNCID: 3585
• Length: 1471
• Species: Homo sapiens
• Sequence 2: NP_996246.1
• Gene: Fancd2 / 2768674
• FlyBaseID: FBgn0038827
• Length: 1478
• Species: Drosophila melanogaster
• Alignment Length: 1541
• Identity: 368/1541 - (23%)
• Similarity: 673/1541 - (43%)
• Gaps: 229/1541 - (14%)

Human     3 SKRRLSKSEDKESLTEDASKTRKQPLSKKTKKSHIANEVEENDSIFVKLLKISGIILKTGESQNQ 67
            |:....:...:.|:...|:..|.|..|:     :||....:.::.|..:|..:|:.|..|:|. .
  Fly    50 SQEHTQRFLSQHSVILAATLGRTQSSSR-----NIATLSRQPNNFFELVLVRAGVQLDQGDSL-I 108

Human    68 LAVDQIAFQKKLFQTLRRHPSYPKIIEEFVSGLESYIEDEDSF-RNCLLSC-------ERLQDEE 124
            ||.|.:....||.:......||...:|.|.:||.:.:...... :..|..|       |::...:
  Fly   109 LACDHVPIVSKLREIFTSASSYTDKMETFKTGLNAAMAPGSKLVQKLLTGCTVDAAGEEQIYQSQ 173

Human   125 ASMGASYSKSLIKLLLGIDILQPAIIKTLFEKLPEYFFENKNSDEINIPR---------LIVSQL 180
            .||..::        |.||.::.|.::.|..|:.|.    ..||.:.:.:         |:::||
  Fly   174 NSMFMNF--------LMIDFMRDACVEVLLNKIEEV----AKSDRVIMGKAAIPLPLLPLMLTQL 226

Human   181 KWL---DRVVDGKDLTTKIMQLISIAPENLQHDIITSLPEILGDSQHADVGKELSDLLIENTSLT 242
            ::|   .:|    ::.::|..:.:.|.|:.:.|||.:...||..|.|    .|..:||..|.|.|
  Fly   227 RYLTASHKV----EIYSRIEVIFNRATESAKLDIIANAELILDASMH----DEFVELLNINYSST 283

Human   243 -----VPILDVLSSLRLDPNFLLKVRQLVMDKLSSIRLED--LPVIIKFILHSVTAMDT----LE 296
                 :..:..|.:|.|......|:|..::|..:|.:..|  ||.:|:.:| :|..:||    .:
  Fly   284 EDLFHMTTVQTLGNLSLSDRTQAKLRVRILDFATSGQCSDAILPHLIRLLL-NVLKIDTDDSVRD 347

Human   297 VISELREKLDLQHCVLPSRLQASQVKLKSKGRASSSGNQESSGQSCIILLFDVIKSAIRYEKTIS 361
            :|..||...:.:|.....::.||:...||:                 :.||..::..:...|...
  Fly   348 LIGSLRGIFNWRHTNETEKISASEDSKKSQ-----------------LELFGFLELGLIRSKKFY 395

Human   362 EAWIKAIENTASV--SEHKVFDLVMLFIIYSTNTQTKKYIDRVLRNKIRSGCIQEQLLQSTFSVH 424
            :|   ...::|||  :|...||:::|.::...|.....||:.:||.:|:...|...:|:.....:
  Fly   396 QA---CQRSSASVPAAEFTSFDMILLLLLIHVNEDNSLYIENILRRRIKLEHITVSILEEIRQHY 457

Human   425 YLVLKDMCSSILSLAQSLLHSLDQSIISFGSLLYKYAFKFFDTYCQQEVVGALVTHICSGNEAEV 489
            ..:|:...::::::....:...::.:..|....|...||.|:: .|:.::..|:...|..:...:
  Fly   458 RHILEQHITTLMNILHDFMREKNRIVSDFAKSSYSILFKIFNS-IQKNILKKLLELTCDKSSPHL 521

Human   490 DT-ALDVLLELVVLNPSAMMMNAVFVKGILDYLDNISPQQIRKLFYVLSTLAFSKQN-EASSHIQ 552
            .| ||::|.||...:...:...|..:..:||.:.::|..|.|....:|..:||...| .....:|
  Fly   522 TTMALELLRELQRKSAKDVQNCATLLIPMLDRISDLSLTQTRVAMDLLCHVAFPDPNLSPCLQLQ 586

Human   553 DDMHLVIRKQLSSTVFKYKLIGIIGAVTMAGIMA------ADRSESPSLTQERANLSDEQCTQVT 611
            :.:.:|::|||.:::...|..||||.|.:...||      .||.|..:..:...:|.|.:.....
  Fly   587 EQVDMVVKKQLINSIDNIKKQGIIGCVQLIDAMARIANNGVDRDEFIASVENVDSLPDGRGKMAA 651

Human   612 SLLQLVHSCSEQSPQASALYYDEFANLIQHE-------KLDPKALEWVGHTICNDFQDAFVVDSC 669
            :|:....:....|.::.||:::|.|.:....       :||.:.:.|....:...||.:||.::
  Fly   652 NLIIRTEASIGNSTESLALFFEELATVFNQRNEGTSGCELDNQFIAWACDLVTFRFQASFVTEN- 715

Human   670 VVPEGDFPFPVKALYGLEEYDTQD--------GIAINLLPLLFSQDF-AKDGGPVTSQESGQKLV 725
             |||......::....:.|.|..|        .|.||:..|:.|... |.|
  Fly   716 -VPETLKGIKLEYQLNINELDDTDANTESDVLNIGINISKLVLSPKVKACD-------------- 765

Human   726 SPLCLAPYFRLLRLCVERQHNGNLEEIDGLLDC----PIFLTDLEPGEKLESMSAKERSFMCSLI 786
            |...|||.|..:|:..:.:|..:||.|:.||.|    |.|..|.......|:..|:::..:.|:.
  Fly   766 SIYVLAPLFNYVRVLYKHRHQDSLESINALLGCAIVLPSFFEDDNYVSVFENFEAEQQKDILSIY 830

Human   787 FLTLNWFREIVNAFCQETSPEMKGKVLTRLKHIVELQIILEKYLAVTP-DYVPPLGNFDVETLDI 850
            |.|:||.|..::||..:..|..:.:||:||..::.::..::..||..| |:|.|...|
  Fly   831 FHTVNWMRVSISAFASQRDPPTRRRVLSRLGELIRIEQRMKPLLARAPVDFVAPPYQF------- 888

Human   851 TPHTVTAISAKIRKKGKIERKQKTDGSKTSS--SDTLSEEKNSECDPTPSHRGQLNKEFTGK--- 910
                :|.:...       .:.||..|.|.::  :.||.|...:...|:.:       :||.|
  Fly   889 ----LTNVKLS-------NQNQKRPGPKPAAKLNATLPEPDLTGNQPSIA-------DFTIKVGQ 935

Human   911 ----EEKTSL-LLHNSHAFFRELDIEVFSILHCGLVTKFILDTEMHTEATEVVQLGPPELLFLLE 970
                :.||.. .::.....:|.:::|:..:|   :..||:|:.::..|..... ||..||.||||
  Fly   936 CKTVKTKTDFEQMYGPRERYRPMEVEIIMLL---VEQKFVLNHQLEEEQMGEF-LGLLELRFLLE 996

Human   971 DLSQKLESMLTPPIARRVPFLKNKGSRNIGFSHLQQRSAQEIVHCVFQLLTPMCNHL----ENIH 1031
            |:.||||:.:          |::..|.:...........::.:..:...|..:.|||    |.|.
  Fly   997 DVVQKLEAAV----------LRHHDSYDADSFRPHLAKPEDFICDLLPCLHEVNNHLITLGEAID 1051

Human  1032 NYFQCLAAENHGVVDGPGVKVQEYHIMSSCYQRLLQIFHGLFAWSGFSQPENQNLLYSALHVLS- 1095
            |.   |...:| |.....:...::..:.||:...:::|...||||.:|....:.||:.:|..|.
  Fly  1052 NQ---LTEVSH-VYSNLDLFKDQFCYIKSCFGLCVRLFALYFAWSEWSDKSQEQLLHKSLLKLQP 1112

Human  1096 ----SRLKQGEHSQPLEELLSQSVHYLQNFHQSIPSFQCALYLIRLLMVILE----KSTASA--- 1149
                .||::    |.:.:|.:.:..|...:.:|:.:...|::|.|||..:|:    :|.||.
  Fly  1113 KTQWKRLEK----QSVPQLANLTFQYFLKYEKSVLNLSTAVHLHRLLCNLLKLGSLQSDASQPRF 1173

Human  1150 QNKEKIASLARQFLCRVW--PSGDKEKSNISNDQLHALLCIYLE------HTESILKAIEEIAGV 1206
            |..|.:..|....|.|.|  .||..:|....|..|..|:..:|:      .||.:.:.:::.:
  Fly  1174 QQAEDLRILCGTLLRRKWFHYSGTLDKGGQCNIYLDELVKGFLKKSNAKSQTELLTELVKQCS-- 1236

Human  1207 GVPELINSPKDASSSTFPTLTRHTFVVFFRVMMAELEKTVKKIEPGTAADSQQIHEEKLLYWNMA 1271
                ::|: ||.:.::||...:..|.:.||.:   .|..:..:....:.||:   .:||..|..|
  Fly  1237 ----ILNT-KDKALTSFPNFKKANFPLLFRGL---CEVLIHSLSGQVSVDSR---GDKLKLWESA 1290

Human  1272 VRDFSILINLIKVFDSHPVLHVCLKYGRLFVEAFLKQCMPLLDFSFRKHREDVLSLLETFQLDTR 1336
            |...:.|:::::..:......:.||:..||::..|:..|..|:...|:..|.:...|...|..||
  Fly  1291 VDLLNGLLSIVQQVEQPRNFGLFLKHSLLFLKLLLQHGMSALESIVREDPERLTRFLHELQKVTR 1355

Human  1337 LLHHLCGHSKIHQDTRLTQHVPLLKKTLELLVCRVKAMLTLNNCREAFWLGNLKNRDLQGEEI-- 1399
            .||.||.|||..::|.:..::|.|::|:|.||.||||:|..|||..||.:||:.||||.|:.|
  Fly  1356 FLHQLCCHSKSIKNTAIISYIPSLRETIETLVFRVKALLAANNCHSAFHMGNMINRDLHGDSIIT 1420

Human  1400 -------KSQNSQESTADESEDDMSSQASKSKATEVSLQNPPESGT 1438
                   :..:..|..||::..|.:........|.||:...|..|:
  Fly  1421 PRSSFAGEENSDDELPADDTSVDETVLGDDMGITAVSVSTRPSDGS 1466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FANCD2	NP_149075.2	Interaction with FANCE	1..291		73/314 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..37		6/33 (18%)
		FancD2	35..1415	CDD:464225	356/1484 (24%)
		Interaction with BRCA2	248..359		25/116 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	868..906		8/39 (21%)
Fancd2	NP_996246.1	FANC	132..1422	CDD:473054	338/1407 (24%)