Protein Alignment FANCD2 and Fancd2

DIOPT Version :10

• Sequence 1: NP_149075.2
• Gene: FANCD2 / 2177
• HGNCID: 3585
• Length: 1471
• Species: Homo sapiens
• Sequence 2: NP_001028416.2
• Gene: Fancd2 / 211651
• MGIID: 2448480
• Length: 1450
• Species: Mus musculus
• Alignment Length: 1430
• Identity: 1074/1430 - (75%)
• Similarity: 1215/1430 - (84%)
• Gaps: 6/1430 - (0%)

Human     1 MVSKRRLSKSEDKESLTEDASKTRKQPLSKKTKKSHIANEVEENDSIFVKLLKISGIILKTGESQ 65
            |:||||...|||||:||||||||  .||||..||||.::|||||.|:||||||.||:.|||||:|
Mouse     1 MISKRRRLDSEDKENLTEDASKT--MPLSKLAKKSHNSHEVEENGSVFVKLLKASGLTLKTGENQ 63

Human    66 NQLAVDQIAFQKKLFQTLRRHPSYPKIIEEFVSGLESYIEDEDSFRNCLLSCERLQDEEASMGAS 130
            |||.|||:.||:||||.||:||:|||:|||||:|||||.||.:|.||||||||||||||||||..
Mouse    64 NQLGVDQVIFQRKLFQALRKHPAYPKVIEEFVNGLESYTEDSESLRNCLLSCERLQDEEASMGTF 128

Human   131 YSKSLIKLLLGIDILQPAIIKTLFEKLPEYFFENKNSDEINIPRLIVSQLKWLDRVVDGKDLTTK 195
            |||||||||||||||||||||.||||:|::.||::|.|.||:.|||::|||||||:|||||||.:
Mouse   129 YSKSLIKLLLGIDILQPAIIKMLFEKVPQFLFESENRDGINMARLIINQLKWLDRIVDGKDLTAQ 193

Human   196 IMQLISIAPENLQHDIITSLPEILGDSQHADVGKELSDLLIENTSLTVPILDVLSSLRLDPNFLL 260
            :|||||:||.|||||.||||||||||||||:|||||.:||::|||||||||||.||||||||||.
Mouse   194 MMQLISVAPVNLQHDFITSLPEILGDSQHANVGKELGELLVQNTSLTVPILDVFSSLRLDPNFLS 258

Human   261 KVRQLVMDKLSSIRLEDLPVIIKFILHSVTAMDTLEVISELREKLDLQHCVLPSRLQASQVKLKS 325
            |:|||||.||||:||||.|||:||:|||||...:||||:||||.|::|..:||||:||||.||||
Mouse   259 KIRQLVMGKLSSVRLEDFPVIVKFLLHSVTDTTSLEVIAELRENLNVQQFILPSRIQASQSKLKS 323

Human   326 KGRASSSGNQESSGQSCIILLFDVIKSAIRYEKTISEAWIKAIENTASVSEHKVFDLVMLFIIYS 390
            ||.||||||||:|.:.||:|:||||||||||||||||||.||||...|.:|||..|:|||.||||
Mouse   324 KGLASSSGNQENSDKDCIVLVFDVIKSAIRYEKTISEAWFKAIERIESAAEHKALDVVMLLIIYS 388

Human   391 TNTQTKKYIDRVLRNKIRSGCIQEQLLQSTFSVHYLVLKDMCSSILSLAQSLLHSLDQSIISFGS 455
            |:|||||.::::|||||:|.|||||||.|.||.|||||||:|.|||.|||:|.||.||.||.|||
Mouse   389 TSTQTKKGVEKLLRNKIQSDCIQEQLLDSAFSTHYLVLKDICPSILLLAQTLFHSQDQRIILFGS 453

Human   456 LLYKYAFKFFDTYCQQEVVGALVTHICSGNEAEVDTALDVLLELVVLNPSAMMMNAVFVKGILDY 520
            |||||||||||||||||||||||||:|||.||||||||||||||:|||.|||.:||.||||||||
Mouse   454 LLYKYAFKFFDTYCQQEVVGALVTHVCSGTEAEVDTALDVLLELIVLNASAMRLNAAFVKGILDY 518

Human   521 LDNISPQQIRKLFYVLSTLAFSKQNEASSHIQDDMHLVIRKQLSSTVFKYKLIGIIGAVTMAGIM 585
            |:|:|||||||:|.:|||||||:|...|:||||||||||||||||||||||||||||||||||||
Mouse   519 LENMSPQQIRKIFCILSTLAFSQQPGTSNHIQDDMHLVIRKQLSSTVFKYKLIGIIGAVTMAGIM 583

Human   586 AADRSESPSLTQERANLSDEQCTQVTSLLQLVHSCSEQSPQASALYYDEFANLIQHEKLDPKALE 650
            |.|||...:.:|..||:|.||.|||||||||||||:|.||.||:|||||||||||..||.||.||
Mouse   584 AEDRSVPSNSSQRSANVSSEQRTQVTSLLQLVHSCTEHSPWASSLYYDEFANLIQERKLAPKTLE 648

Human   651 WVGHTICNDFQDAFVVDSCVVPEGDFPFPVKALYGLEEYDTQDGIAINLLPLLFSQDFAKDGGPV 715
            |||.||.||||||||||.|..||||||||||||||||||.|||||.||||| ||.|:.|||....
Mouse   649 WVGQTIFNDFQDAFVVDFCAAPEGDFPFPVKALYGLEEYSTQDGIVINLLP-LFYQECAKDASRA 712

Human   716 TSQESGQKLVSPLCLAPYFRLLRLCVERQHNGNLEEIDGLLDCPIFLTDLEPGEKLESMSAKERS 780
            |||||.|:.:|.||||.:||||||||.|||:|||:|||||||||:||.||||||||||||||:||
Mouse   713 TSQESSQRSMSSLCLASHFRLLRLCVARQHDGNLDEIDGLLDCPLFLPDLEPGEKLESMSAKDRS 777

Human   781 FMCSLIFLTLNWFREIVNAFCQETSPEMKGKVLTRLKHIVELQIILEKYLAVTPDYVPPLGNFDV 845
            .||||.|||.|||||:||||||:||||||||||:|||.:||||.||||||||.||||||..:.|:
Mouse   778 LMCSLTFLTFNWFREVVNAFCQQTSPEMKGKVLSRLKDLVELQGILEKYLAVIPDYVPPFASVDL 842

Human   846 ETLDITPHTVTAISAKIRKKGKI-ERKQKTDGSKTSSSDTLSEEKNSECDPTPSHRGQLNKEFTG 909
            :|||:.|.:.:|::||.|.|||. .:|||.|.:|.|.||||..|..||||..||.|..::||.||
Mouse   843 DTLDMMPRSSSAVAAKNRNKGKTGGKKQKADSNKASCSDTLLTEDTSECDMAPSGRSHVDKESTG 907

Human   910 KEEKTSLLLHNSHAFFRELDIEVFSILHCGLVTKFILDTEMHTEATEVVQLGPPELLFLLEDLSQ 974
            ||.||.:.|.|..|||||||||||||||.||||||||||||||||||||||||.|||||||||||
Mouse   908 KEGKTFVSLQNYRAFFRELDIEVFSILHSGLVTKFILDTEMHTEATEVVQLGPAELLFLLEDLSQ 972

Human   975 KLESMLTPPIARRVPFLKNKGSRNIGFSHLQQRSAQEIVHCVFQLLTPMCNHLENIHNYFQCLAA 1039
            |||:|||.|.|:|:...||||.:|||||||.|||.|:|||||.|||||||||||||||:||||.|
Mouse   973 KLENMLTAPFAKRICCFKNKGRQNIGFSHLHQRSVQDIVHCVVQLLTPMCNHLENIHNFFQCLGA 1037

Human  1040 ENHGVVDGPGVKVQEYHIMSSCYQRLLQIFHGLFAWSGFSQPENQNLLYSALHVLSSRLKQGEHS 1104
            |:....|......||.|.|:.|||:|||:.|.||||.||:......||:|||.|||:||||.|..
Mouse  1038 EHLSADDKARATAQEQHTMACCYQKLLQVLHALFAWKGFTHQSKHRLLHSALEVLSNRLKQMEQD 1102

Human  1105 QPLEELLSQSVHYLQNFHQSIPSFQCALYLIRLLMVILEKSTASAQNKEKIASLARQFLCRVWPS 1169
            ||||||:|||..||||||.|:|||||.|||:||||.:||||....|.|||:||||:|.|||.||.
Mouse  1103 QPLEELVSQSFSYLQNFHHSVPSFQCGLYLLRLLMALLEKSAVPNQKKEKLASLAKQLLCRAWPH 1167

Human  1170 GDKEKSNISNDQLHALLCIYLEHTESILKAIEEIAGVGVPELINSPKDASSSTFPTLTRHTFVVF 1234
            |:|||:...||.||.:|.||||||:::|||||||.|||||||:::||||:|||||||||||||:|
Mouse  1168 GEKEKNPTFNDHLHDVLYIYLEHTDNVLKAIEEITGVGVPELVSAPKDAASSTFPTLTRHTFVIF 1232

Human  1235 FRVMMAELEKTVKKIEPGTAADSQQIHEEKLLYWNMAVRDFSILINLIKVFDSHPVLHVCLKYGR 1299
            |||||||||||||.::.||||||||:||||||||||||||||||:||:|||||:|||||||||||
Mouse  1233 FRVMMAELEKTVKGLQAGTAADSQQVHEEKLLYWNMAVRDFSILLNLMKVFDSYPVLHVCLKYGR 1297

Human  1300 LFVEAFLKQCMPLLDFSFRKHREDVLSLLETFQLDTRLLHHLCGHSKIHQDTRLTQHVPLLKKTL 1364
            .||||||||||||||||||||||||||||:|.||:|||||||||||||.||||||:|||||||:|
Mouse  1298 RFVEAFLKQCMPLLDFSFRKHREDVLSLLQTLQLNTRLLHHLCGHSKIRQDTRLTKHVPLLKKSL 1362

Human  1365 ELLVCRVKAMLTLNNCREAFWLGNLKNRDLQGEEIKSQ--NSQESTADESEDDMSSQASKSKATE 1427
            |||||||||||.|||||||||||.|||||||||||.||  :|.||.|::|||.::|..|:::|||
Mouse  1363 ELLVCRVKAMLVLNNCREAFWLGTLKNRDLQGEEIISQDPSSSESNAEDSEDGVTSHVSRNRATE 1427

Human  1428  1427
            Mouse  1428  1427

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FANCD2	NP_149075.2	Interaction with FANCE	1..291		222/289 (77%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..37		25/35 (71%)
		FancD2	35..1415	CDD:464225	1044/1382 (76%)
		Interaction with BRCA2	248..359		82/110 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	868..906		18/38 (47%)
Fancd2	NP_001028416.2	Interaction with FANCE. /evidence=ECO:0000250	1..289		222/289 (77%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..37		26/37 (70%)
		FancD2	33..1415	CDD:464225	1044/1382 (76%)
		Interaction with BRCA2. /evidence=ECO:0000250	246..357		82/110 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	853..879		12/25 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1398..1450		14/30 (47%)