Protein Alignment FANCD2 and fcd-2

DIOPT Version :10

• Sequence 1: NP_149075.2
• Gene: FANCD2 / 2177
• HGNCID: 3585
• Length: 1471
• Species: Homo sapiens
• Sequence 2: NP_001255848.1
• Gene: fcd-2 / 178418
• WormBaseID: WBGene00012767
• Length: 1440
• Species: Caenorhabditis elegans
• Alignment Length: 1517
• Identity: 301/1517 - (19%)
• Similarity: 574/1517 - (37%)
• Gaps: 306/1517 - (20%)

Human    48 FVKLLKISGIILKTGESQNQLAVDQIAFQKKLFQTLRRHPSYPKII--------EEFVSGLESYI 104
            |.::||...:.:...:.:..:.::.              .||.|.:        |:....||..:
 Worm    74 FEEILKEENVRIVNDQDEGMMDMEM--------------GSYEKCVVFGNNLNSEDLCRNLEKRM 124

Human   105 EDE--DSFRNCLLSCERLQDEEASMGASYSKSLIKL-------LLGIDILQPAIIKTLFEKLPEY 160
            |::  ::|...||:|...||..| :..|.:|||..|       .|.|...|......|.:|| ..
 Worm   125 ENDRGETFAEFLLACGSDQDMLA-LFLSPAKSLFGLQDTIFRAFLQIKATQTKAFDFLLQKL-NI 187

Human   161 FFENKNSDEINIPRLIVSQLKWLDRVVDGKDLTTKIMQL-ISIAPENLQHDIITSLPEILGD--- 221
            ..:.::..::.:.:..|:.::.|.|:.:.:.:...|.:. ......|:::|:|.:||||..|
 Worm   188 LAKRQDERDLLLAQTCVAHMRHLSRLFEPQAVFNTIFEFQWRFWSPNVRNDLIAALPEIFTDISL 252

Human   222 --SQHADVGKELSDL--LIENTSLTVPILDVLSSLRLDPNFLLKVRQLVMDKLSSIRLEDLPVII 282
              |....:.||.|:.  :....|..:.|::.|..||:||....|:|..:.:....:....||.::
 Worm   253 QQSTAVRLHKECSETQGVPGLPSFQLQIIETLRLLRMDPGTARKIRMDLCNLCMDLDPACLPSLV 317

Human   283 KFILHSVTAMDTLEVISELREKLDLQHCVLPSRLQASQVKLKSKGRASSSGNQESSGQSCIILLF 347
            .|.|.|:..         .:.|.|.:.......|:.....||..|....:  .:.|..|.|:.:|
 Worm   318 AFSLGSLLV---------FQGKADDEEAHFHEMLRQLARLLKIDGLKKKT--SKPSSDSLIVEVF 371

Human   348 DVIKSAIRYE-----KTISEAWI----KAI-----------ENTASVSEHK------VFDLVMLF 386
            .......|..     |.|: .||    |.:           |.|.|..|.:      .|:..:.|
 Worm   372 GHFLKFFRLNDKRAWKHIT-TWISKSKKPVVATKPEEDMDSEETPSPPEEESATWLTTFEAFLYF 435

Human   387 IIYSTNTQTKKYIDRVLRNKIRSGCIQEQLLQSTFSVHYLVLKDMCSSILSLA----QSLLH--- 444
            .:.|............:.:||.:       :.:.|:..:|.:.|:..|....|    .:|:|
 Worm   436 SLLSNTESCPPTFVAAVNSKILN-------IPAAFTTKFLRIIDLVISCKKFATCHLPALIHVAR 493

Human   445 ----SLDQSIISFGSLLYKYAFKFFDTYCQQEVVGALVTHICSGNEAEVDTALDVLLELV-VLNP 504
                |.|.::...|..::|..|...:...:::|...|:.|. |.:|.|.:..|||..::: ..|.
 Worm   494 HCFWSSDGNVRQMGVSMWKQLFVGMEKRDREKVFTELMKHF-SQSETECEAVLDVFFKVIKSTNS 557

Human   505 SAMMMNAVFVKGILDYLDNISPQQIRKLFYVLSTL-AFSKQNEASSHIQDDMHLVIRKQLSSTVF 568
            |.:...:..::..::.:..:|...|::||.|:..: :.|.:.||:....|:   :|.:.|.|...
 Worm   558 SVIQEFSTQIQKCIELIHKLSIPNIKRLFQVMLMMPSKSTEKEATRFEIDE---IISRFLLSVSD 619

Human   569 KYKLIGIIGAVTMAGI-MAADRSESPSLTQERANLSDEQCTQVTSLLQLVHSCSEQSPQASAL-- 630
            :.|.:|::..:....: |....||:    ||..            :.:.:..|.|....:|||
 Worm   620 REKFLGLLALLMKIQVEMGKKHSEN----QEHL------------VREGISRCEEAVKSSSALRG 668

Human   631 -YYDEFANLIQHEKLDPK---ALEWVGHTICNDFQDAFVVDSCVVPEGDFPFPVKALYGLEEYDT 691
             :|:....::|..|...:   ..:|     ..|....|..|...:|    |.|        |.:|
 Worm   669 AFYEHMRIVLQQHKRTEEIRFLSDW-----STDLLKRFKNDFFELP----PNP--------ESNT 716

Human   692 QDGIAINLLPLLFSQDFAKDGGPVTSQESGQKLVSP--LCLAPYFRLLRLCVERQHNGNLEEIDG 754
            .                     |.:......||.|.  |.:||.|.|::.....:.....|:.|.
 Worm   717 D---------------------PDSQSTWNLKLNSARLLEIAPMFELIKEIQVLKMRWREEDQDS 760

Human   755 L---LDCPI-------FLTDLEPGEKLESMSAKERSFMCSLIFLTLNWFREIVNAFCQETSPEMK 809
            |   .|..:       |...|...|.| .::.:|:   .:.:|..:.|.|.::|.|..::|.:..
 Worm   761 LTSSYDISVIKNLSFAFEAVLPKDENL-PLNRQEK---LAQLFFNVQWTRTVLNGFLSQSSVDFL 821

Human   810 GKVLTRLKHIVELQIIL--EKYLAVTPDYVPPLGNFDVETLDI---TPHTVTAISAKIRKKGKIE 869
            .........|....:::  ||.||.:   :..|..::|..|:.   ....|..||:: :.|.|..
 Worm   822 SSDDVSTLSIKNFYVMMDAEKKLAAS---LVDLATWNVPNLNFGRSGKRDVIVISSE-KTKSKKG 882

Human   870 RKQKTD-------GSKTSSSD-TLSEEKNSECDPTPSHRGQLNKEFTGKEEKTSLLLHNSHAFFR 926
            ||:|:|       ..:|:|:| |::::...|         .|..|.. ||..:.||...||
 Worm   883 RKRKSDETTVIGGDGQTNSADVTVNDDDREE---------NLEAEVV-KEAPSVLLQLKSH---- 933

Human   927 ELDIEVFSILHCGLVTKFILDTEMHTEATEVVQLGPPE---LLFLLEDLSQKLESML-----TPP 983
            .:.:::..|:|                   :::|...:   |.:|.::|...:::::     |||
 Worm   934 YIPLKLRPIVH-------------------LMKLANKKRSALKYLCDELQSVIDTLIKQKKKTPP 979

Human   984 I---ARR--VPFLKNKGSRNIGFSHLQQRSAQEIVHCVFQLLTPMCNHLENIHNYFQCLAAENHG 1043
            :   |||  .|...|...    |.|   ..:..|..||.:.:..:...:|.:...|    ||...
 Worm   980 MLLAARRAAAPTTPNSSK----FYH---GDSVTIWFCVKKAVEQVWGIVELVFGVF----AEQSD 1033

Human  1044 VVDGPGVKVQEYHIMSSCYQRLLQIFHGLFA---------WSGFSQPENQNLLYSALHVLSSRLK 1099
            .......:||:  .|....::.|.:.|.:.:         .|...:.|.:::|   :.::..::.
 Worm  1034 ASQELKSRVQK--DMDDLGEKSLNLIHSILSGELYGGEEKLSPAERVERKSVL---IRIIEKKML 1093

Human  1100 QGEH-SQPLEELLSQSVHYLQNFHQSIPSFQCALYLIRLLMVILEKSTASAQNKEKIASLARQFL 1163
            ..|| |...|:...:...:|....:..|:...|:.::.:...:.......|:.::.:|..|..:|
 Worm  1094 SSEHLSNDSEKARVEIGKFLAKSAEFSPTPAVAVAILDVFEDLKLDEDDDAETRKIMAKYALAYL 1158

Human  1164 CRVWPSGDKEKSN------ISNDQLHALLCIYLEHTESILKAIEEIAGVGVPELINS-------- 1214
            .:.|...|:..|.      ...|.||..  |.|...:..|.||:.|....|.:|:..
 Worm  1159 KKDWSKVDELWSKGTRYTCAVRDILHHY--IRLRKEKDQLLAIQWILTNKVVQLVPEDDKRKSCV 1221

Human  1215 ----------PKDASSSTFPTLTRHTFVVFFRVMMAELEKTVKKIE-PGTAADSQQIH-EEKLLY 1267
                      .|:...:||..:::.||.|.|:.:...|.....|.: ..:||.:..:. |:.|..
 Worm  1222 FSQQSDDDLLEKEDRKATFYCISKTTFGVIFKTLFGNLNSRCLKYDMSASAAKNGGVDIEDTLES 1286

Human  1268 WNMAVRDFSILINLIKV--FDSHPVLHVCLKYGRLFVEAFLKQC--MPLLDFSFRKHREDVL--- 1325
            |..|...|.||..|:::  ..:..||...:|.|:.|:....|:.  :.|:|...:....|.:
 Worm  1287 WETASSCFLILCLLLRINKIRTTAVLTSAIKEGKQFLITVSKKSSFIFLMDNITKGTNFDTICRR 1351

Human  1326 --SLLETFQLDTRLLHHLCGHSKIHQDTRLTQHVPLLKKTLELLVCRVKAMLTLNNCREAFWLGN 1388
              .:|...|...|:|..:...:|.::...|.:..|.|:...|..:..:.:.:..|.|..||.:|.
 Worm  1352 VEKILSAVQQGNRVLQSIGTFAKTNKCVLLLKKFPELRAESENCLRVIHSAMVKNECLNAFTVGL 1416

Human  1389 LKNRDLQGEEIKSQNSQESTAD 1410
            :|:|.:.|:.|..|.:.|..:|
 Worm  1417 VKSRSIDGDIIMDQRASEIDSD 1438

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FANCD2	NP_149075.2	Interaction with FANCE	1..291		58/267 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..37
		FancD2	35..1415	CDD:464225	301/1517 (20%)
		Interaction with BRCA2	248..359		23/115 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	868..906		10/45 (22%)
fcd-2	NP_001255848.1	FANC	142..1431	CDD:473054	284/1426 (20%)