DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ube2o and Bruce

DIOPT Version :9

Sequence 1:	NP_776116.2	Gene:	Ube2o / 217342	MGIID:	2444266	Length:	1288	Species:	Mus musculus
Sequence 2:	NP_001262460.1	Gene:	Bruce / 41260	FlyBaseID:	FBgn0266717	Length:	4976	Species:	Drosophila melanogaster

Alignment Length:	969	Identity:	218/969 - (22%)
Similarity:	348/969 - (35%)	Gaps:	298/969 - (30%)

- Green bases have known domain annotations that are detailed below.

Mouse   483 TDDTSSVTSSASSTT----------SSQSG-------------SGTGRKKSIPLSIKNLKRKHKR 524
            :||||....:.::.|          ||..|             ..:|||.::..|        ::
  Fly  4096 SDDTSEAKKTKAACTEPLPSPLQRFSSSGGLSLLAHYLPTVYPEHSGRKTTLVFS--------EK 4152

Mouse   525 KKNKVTRDF---KPGDRVAVEVVTTMTSADVMWQDGSVECNIRSNDLFPVHHLDNNEFCPGDFVV 586
            :|:....|:   :|.|.:..::      .|.:.:..:....:.|   .|.|.|       ..|.:
  Fly  4153 EKSPPLSDWVKLEPNDEIYEDL------EDTLCEPAAKLATVSS---VPQHSL-------AAFGL 4201

Mouse   587 DKRVQSCPDPAVYGVVQSGDHVGRTCMVKWFKLRPSGDDVELIGEEEDVSVYDIADH-PDFRFR- 649
            ..|:     || |..|...|.:...|::: ..|..:||     |:..|:....:|.. |...|.
  Fly  4202 FLRL-----PA-YSDVLLRDKMRAQCLLR-LVLGVTGD-----GDGNDIYSLSLAPSLPTLPFEV 4254

Mouse   650 ----------TTD-------IVIRIG-----------------NTEDGALPKEDEPS-------- 672
                      :||       :||.:|                 |...||...|..||
  Fly  4255 FRQLLDSVPLSTDDGVLLRRVVIEVGAMHLVLNCLGIFSHQSHNNRIGAPISEPSPSGTSSGSGT 4319

Mouse   673 ------VGQVARVDVSSKVEVVWADNSKTIILPQHLYNIESEIEESDYDSVEGSSSGASSDEWED 731
                  .|.|:....::..|   |..|.|.....|:|            ..:|:..|..|
  Fly  4320 IGNGSGNGSVSGTKTNAPEE---ATPSATSDDKSHMY------------WAKGTGFGTGS----- 4364

Mouse   732 DSDSWETDNGLV----DDEHPKIEELAA--------ILPAE---QPTAPEEDKGVVISEEAATAA 781
            .:.||..:..|:    ::||..:..|..        .:|:|   :......|...|..|  ....
  Fly  4365 TTQSWNVEQALLRQKSEEEHVTVLLLVLASYINPGDCIPSEMCGEDILAYHDVRDVTGE--LPPI 4427

Mouse   782 IQGAVAMAAPVAGLMEKAGKDGPPKSFRELKEAIKILESLKNMTVEQLL----------TGSPTS 836
            .|..:..:..:..|......|......|.:.....||:.|:.:::.::|          :|..|.
  Fly  4428 FQTLLQQSCLIPALSSYLRNDSVLDITRHIPLYRAILKLLRALSLSKMLVSLLQPSASGSGDSTP 4492

Mouse   837 PTVEPEKPTREKKFLDD-IKKLQENLKKTLD--------NVAIAEEEKME-AVPDTERKEEKPEV 891
            |.|  |..|..|..:|. .|:|:.|.|..:.        |:...::|.:. .:||..
  Fly  4493 PIV--ELLTSMKTCVDTYAKRLKVNKKSNIKGQTHQLTFNIDDGDDEGLALLIPDIH-------- 4547

Mouse   892 QSPVKAEWPSETPVLCQQ---CGGRPGVTFTSAKG------------------------EVFSVL 929
                      ||.||.|:   ......:..|:..|                        :.|.::
  Fly  4548 ----------ETSVLVQKTTDADALINMLHTNEDGSAQLEPQSKSIEQRYLELMKKRQFDTFDMI 4602

Mouse   930 EFAPSN-------HSFKKI------EFQPPEAKKFFSTVRKEMALLATSLP----DGIMVKTFED 977
            ..:.:|       |.|:|:      .:.|...|:    :.:|...|:||||    ..:.|:...|
  Fly  4603 VESDNNSFRFVVSHHFEKMVRLAGDRYHPSRVKR----LAQEAVTLSTSLPLSFSSSVFVRCDTD 4663

Mouse   978 RMDLFSALIKGPTRTPYEDGLYLFDIQLPNIYPAVPP--HFCYLSQCSGRLNPNLYDNGKVCVSL 1040
            |:|:...||.||..|||.:|.:.||:..|..||..|.  :.....:.|.|.|||||::||||:|:
  Fly  4664 RLDIMKVLITGPADTPYANGCFEFDVFFPPDYPNQPMLINLETTGRHSVRFNPNLYNDGKVCLSV 4728

Mouse  1041 LGTWIGKGTERWTSK-SSLLQVLISIQGLILVNEPYYNEAGFDSDRGLQEGYENSRCYNE---MA 1101
            |.||.|:..|:|.:: ||.||||:|||.||||.|||:||.||:..||...|..:||.||.   .|
  Fly  4729 LNTWHGRPEEKWNAQTSSFLQVLVSIQSLILVPEPYFNEPGFERSRGSPSGTNSSREYNSNIYQA 4793

Mouse  1102 LIRVVQSMTQLVRRPPEVFEQEIRQHFSVGGWRLVNRIESWLE---------------------- 1144
            .:|  .:|.:.:|.|.:.|:..|.:||.:....:..:||.|:|
  Fly  4794 CVR--WAMLEQIRSPSQCFKDVIHKHFWLKREEICAQIEGWIEELGKPQYTERASRTISFNSMVL 4856

Mouse  1145 ----THAMQERAQVMPNGALKD-SSSLEPMAAAELSDSGREEPEDV-GMAPGEASQGSDSEGGAQ 1203
                .|..:|.:::.|...|:| .:...|:|..        .|.|| .:||..|:..:..   ||
  Fly  4857 RRHYRHLREELSKLKPPRGLEDLDAPFNPVATL--------PPMDVSAVAPSLAATNTVQ---AQ 4910

Mouse  1204 GPASASRDHTEQTETAPDASAPPSVRPKRRRKSYRSFLPEKSGYPDIGFPLFPLSKGFI 1262
            ...:...|.|...|.|.:..|....              |..|..|.||..||..:|.:
  Fly  4911 PDDAIVTDITLLGENADECEADGDA--------------EGDGEVDDGFKGFPQEEGLL 4955

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube2o	NP_776116.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	80..109
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	396..529		13/68 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	711..743		5/31 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	872..899		3/27 (11%)
		UBCc	955..1105	CDD:238117	70/159 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1158..1247		18/90 (20%)
Bruce	NP_001262460.1	BIR	251..321	CDD:279047
		DUF3643	3539..3664	CDD:289152
		UQ_con	4636..4790	CDD:278603	69/157 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0895
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810