DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gpr179 and CG43795

DIOPT Version :9

Sequence 1:	NP_001074689.1	Gene:	Gpr179 / 217143	MGIID:	2443409	Length:	2293	Species:	Mus musculus
Sequence 2:	NP_001097435.2	Gene:	CG43795 / 5740629	FlyBaseID:	FBgn0264339	Length:	1420	Species:	Drosophila melanogaster

Alignment Length:	1104	Identity:	275/1104 - (24%)
Similarity:	430/1104 - (38%)	Gaps:	305/1104 - (27%)

- Green bases have known domain annotations that are detailed below.

Mouse    62 FLYSGDVQRLSGANCSEKYEVRGAEGKAGVPPVLQRAAGTLAQ-----AANFLNMLLQANDIRES 121
            ||...:.|.|.|:||.....:...||      |:.|.|....:     |.|..|||.:.......
  Fly   408 FLQYIEQQHLMGSNCVAGTSLNLGEG------VVDRYAQDRFRVEAEVAVNRANMLTRIFKTTGR 466

Mouse   122 SVEEDVEWYQALVRSVAEGD-----------------------PKAYRALLTFNPAPGASHL--- 160
            ||:|||....|.|.|:.|.|                       |.|||.     |.|....:
  Fly   467 SVQEDVNLLHASVLSMVEFDDDIFAAGNCFDWNEHPAQPGLFCPFAYRL-----PPPNLGAVFAK 526

Mouse   161 QLALQATRMGD------------ETVLQ---------DLSGNKVQEETPGEDLDRPVLQKRVLTN 204
            .||::...:|:            |.|:.         .|..|:.:|....:.|
  Fly   527 DLAMEYHYLGNTSEWFFLARKNAEKVIARNEQYLKSFHLYSNRTEERIEDDTL------------ 579

Mouse   205 DLRSLDSPKWPRGDGYVGDIQQVKLSPPFLECHEGQLRPGWLVTVSATFYGLKPDLTPEVRGQVQ 269
                  :.|:..|          :.|.|:.:|..|.:   |::|.:..|:|.: :.|...:|...
  Fly   580 ------AVKYEDG----------RWSKPYYDCGGGNI---WMLTYTVPFFGYE-NGTYHFKGTSG 624

Mouse   270 MDIDLQSVDINQCAS--GPGW------YSNTHLCDLNSTQCVPLESQGFVLGRYLCRCRPGFYGA 326
            :||||:.|||:||..  .||.      ::.|..|...:|.|..:...||..|.|.|.||.|||..
  Fly   625 IDIDLRRVDIDQCPQRHTPGTKRPLNIFAGTDKCKQRTTMCEAIMGLGFRRGSYKCLCRKGFYFP 689

Mouse   327 ---------SGSGGLEESATQAAGQFGSPQDSLGKLLRCQPCPEGCTSCLDATPCLVEEALALRT 382
                     :||...||......|: .|..:|..: ..|.||.|||.||.|::||:......:||
  Fly   690 DIVSQHKFFNGSLLEEEYEKLMLGK-NSTYNSNSE-YECLPCAEGCDSCEDSSPCIAALNWPMRT 752

Mouse   383 AVLACQACCMLAVF-LSMLVAYRCRGSKRIRASGIVLLETILFGSLLLYFPVFILYFKPSVFRCV 446
            ::||. ||.::.:. .:....:|.:..|.:||:...||..|..|:..:|....::|..|:::.|.
  Fly   753 SILAL-ACIVIGLLPPAAWFTFRYQQVKVVRAASPALLRVIALGAFFIYCTNIVMYPNPNLYTCT 816

Mouse   447 ALRWVRLLGFAVVYGTIILKLYRVLQLFLSRTAQRVPHPSSGQLLRRLGQLLLLVLGFLVVWTAG 511
            |..|:|.:||::.||.::||.:|:..:|..|:|:.| ..:...||:|||.:            .|
  Fly   817 ARIWLREIGFSLTYGALMLKTWRISVIFRVRSAKAV-KITDAALLKRLGII------------CG 868

Mouse   512 ALEPGTQHTALVTR----------GHTPTGRHFYLCHHDHWDYIMVVAEMLLLCWGSFLCYATRA 566
            |:     .|.|:.|          |.|......:||..|.|||.....|:|.|.||..||...|.
  Fly   869 AI-----GTCLLVRTLVSPPDVVVGRTADDLKAFLCKTDWWDYTFTSMEVLFLAWGVRLCIMVRK 928

Mouse   567 VPSAFHEPRYMSIALHNELLLSTAFHTARFVLVPSLHPDWTLLLFFLHTHSTVTATLALIFIPKF 631
            .||.|:|.|::|:|::||.||:...:.:...|....:||...::||.||..|||..|||||..|.
  Fly   929 APSEFNESRFISMAIYNEFLLTCFLNVSMLFLQSPANPDLLYIIFFCHTQLTVTLLLALIFGSKV 993

Mouse   632 W---KPGAPPREEILDEVYEDELDLQRSGSYLN-----------SSIASAW----SERSLEPGDI 678
            :   :.|...:|.|       .:..:.||:..|           ||:.::.    :|..|...:.
  Fly   994 YIVLRSGKSHQENI-------GMGTKASGAKFNFRPQVRTFANPSSVTTSTVPVAAETKLSDQEA 1051

Mouse   679 RDELKKLYAQLEIRKTKEMAANNPHLPK-------------------------KRGSSHQGLGRS 718
            .:|:::|..||:  :.:|||.     ||                         ..|::.|  |.|
  Fly  1052 LEEIRQLSMQLQ--RIQEMAP-----PKGVAVMTISSLLDGLKTPGGLMVVAAAAGATAQ--GHS 1107

Mouse   719 FMRYLAEFP--------EALARQHSRDSGSLGLGSLPGSSRRRLLSSSLQETEKPPALRKTRSTY 775
            .....:..|        :..::|::..:|..|.|       |..:.:.:.||  ||:.....:.|
  Fly  1108 AANRQSALPLLALNVEMQKYSQQNNNSNGGRGSG-------RTSIPTMVLET--PPSSTPPSAAY 1163

Mouse   776 DHHREHNTLPFDSTLRRTLSKKASPTDGRESL----ADG------------------PPALGFRS 818
            :              .|.::.:.|..|.||.|    |||                  ||    ||
  Fly  1164 E--------------ERAVNTELSGDDFREQLLRRTADGHIICSRCLDASKEHYYCCPP----RS 1210

Mouse   819 ASAHNLTVGERLPRARPISLQKSLSVAAGSREKALLVASQAYLEETYRQAKEREERKKAEAAMVS 883
            |..|   :|.  |:.     :.|||.|   ..|...:.||:  |:..:...:|:.|.....|..:
  Fly  1211 ACDH---LGS--PKE-----EGSLSFA---NIKLECMCSQS--EDLDQDVGQRQRRPTVRTAATN 1260

Mouse   884 PVRRPSTRRLEWP---LRAPLSAP-----------PSPGKSSSMDSSQTTARP---HEEAGRRLP 931
               .|.|.....|   |.|.||..           ...|:..|...||....|   .:.||:.
  Fly  1261 ---TPPTSCKRAPRNLLEAELSISYQICDNCRSKYKLTGRRRSGSYSQAQENPQLGQQPAGQL-- 1320

Mouse   932 HPPIRHQVSTPVLALSGICLGEPRMLSPTPA--STLAPILLPAPAPAPAPVLAPVSKPPQSPTL 993
              ||:.: ||.:|..:.....|..:.:.|.|  ||...:|.   :.||..:.|.:::|..:|:|
  Fly  1321 --PIQSR-STELLDRTTAAEVETEVEARTKAAHSTDDIVLY---SSAPEELAAQLAEPVAAPSL 1378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gpr179	NP_001074689.1	EGF_CA	278..327	CDD:238011	20/65 (31%)
Gpr179	NP_001074689.1	7tm_3	392..632	CDD:278433	79/250 (32%)
CG43795	NP_001097435.2	7tm_3	754..995	CDD:278433	83/259 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	134	1.000	Domainoid score	I4981
eggNOG	1	0.900	-	-		E1_KOG4418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001877
OrthoInspector	1	1.000	-	-		otm43614
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR32546
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2486
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.910