DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Taok1 and Pak

DIOPT Version :9

Sequence 1:	NP_001351062.1	Gene:	Taok1 / 216965	MGIID:	1914490	Length:	1001	Species:	Mus musculus
Sequence 2:	NP_001138013.2	Gene:	Pak / 44039	FlyBaseID:	FBgn0267698	Length:	840	Species:	Drosophila melanogaster

Alignment Length:	315	Identity:	128/315 - (40%)
Similarity:	176/315 - (55%)	Gaps:	22/315 - (6%)

- Green bases have known domain annotations that are detailed below.

Mouse     2 PSTNRAGSLK----DPEIAE----LFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKK 58
            |:|..|.:.|    |.||.|    :....||.:.:|.:.:||.|:.|.||.|.:..|...||||:
  Fly   532 PNTRAANAKKKKMSDEEILEKLRTIVSVGDPNRKYTKMEKIGQGASGTVYTAIESSTGMEVAIKQ 596

Mouse    59 MSYSGKQSTEKWQDIIKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCL-GSASDLLEVHKKP 122
            |:.|.:...|.   ||.|:..::..||||.:.|...||.....|:||||.. ||.:|:  |.:..
  Fly   597 MNLSQQPKKEL---IINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPGGSLTDV--VTETC 656

Mouse   123 LQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPANS----FV 183
            :.|.:|||:....||.|.:||::.:||||||:.||||...|.|||.|||..:..||..|    .|
  Fly   657 MDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMV 721

Mouse   184 GTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPTL-QS 247
            ||||||||||:   ...||..|||:|||||..||:.|.:||..|.|.:.|||.||.|..|.: :.
  Fly   722 GTPYWMAPEVV---TRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEK 783

Mouse   248 NEWSDYFRNFVDSCLQKIPQDRPTSEELLKHMFVLRERPETVLIDLIQRTKDAVR 302
            ::.|..|::|:|.||:.....|.::.:||||.|:...||...|..||...|:|.:
  Fly   784 DKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFLKLARPLASLTPLIMAAKEATK 838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Taok1	NP_001351062.1	STKc_TAO1	2..318	CDD:270805	128/315 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	324..380
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	404..433
		SbcC	<442..>877	CDD:223496
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	567..587
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	905..1001
Pak	NP_001138013.2	PBD	83..137	CDD:279166
		STKc_PAK_I	558..818	CDD:270814	113/267 (42%)
		S_TKc	566..817	CDD:214567	110/258 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910