DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tek and drpr

DIOPT Version :9

Sequence 1:	NP_038718.2	Gene:	Tek / 21687	MGIID:	98664	Length:	1123	Species:	Mus musculus
Sequence 2:	NP_001261276.1	Gene:	drpr / 38218	FlyBaseID:	FBgn0027594	Length:	1042	Species:	Drosophila melanogaster

Alignment Length:	315	Identity:	84/315 - (26%)
Similarity:	115/315 - (36%)	Gaps:	88/315 - (27%)

- Green bases have known domain annotations that are detailed below.

Mouse   209 RRCEAQKWGPD--------------------------------CSRPCT------------TCKN 229
            |.|||.|:|.|                                |:||||            .|||
  Fly   346 RICEANKYGLDCNRTCECDMEHTDLCHPETGNCQCSIGWSSAQCTRPCTFLRYGPNCELTCNCKN 410

Mouse   230 NGVCHEDTGECICPPGFMGRTCEKACEPHTFGRTCKERCSGPEGCKSYVFCLPDPYGCSCATGWR 294
            ...|....|.|:|.||:.|.|||::|||.|||:.|..||....|.|    |.|:...|.|..||:
  Fly   411 GAKCSPVNGTCLCAPGWRGPTCEESCEPGTFGQDCALRCDCQNGAK----CEPETGQCLCTAGWK 471

Mouse   295 GLQCNEACPSGYYGPDCKLRCHCTNEEICDRFQG-CLCSQGWQGLQCEKEGRPRMTPQIEDLPDH 358
            .::|:..|...::|.||...|.|.|...|:...| |.|:.||.|.:||:
  Fly   472 NIKCDRPCDLNHFGQDCAKVCDCHNNAACNPQNGSCTCAAGWTGERCER---------------- 520

Mouse   359 IEVNSGKFNPICKASGWPLPTSEEMTLVKPDGTVLQPNDFN------------YTDRF-SVAIFT 410
             :.::|||...| |.......:..:.....:|..:...|:.            |.:.. .|....
  Fly   521 -KCDTGKFGHDC-AQKCQCDFNNSLACDATNGRCVCKQDWGGVHCETNCRSGYYGENCDKVCRCL 583

Mouse   411 VNRVLPPDSGVWVCSVNTVAGMVEKP-----FNISVKV-LPEPLHAPNVID--TG 457
            .|....||||..:||.........:|     :.:..|. .||.||.....|  ||
  Fly   584 NNSSCDPDSGNCICSAGWTGADCAEPCPPGFYGMECKERCPEILHGNKSCDHITG 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tek	NP_038718.2	Ig_Tie2_1	24..118	CDD:287411
		EGF_Lam	230..275	CDD:238012	20/44 (45%)
		EGF_2	311..340	CDD:285248	11/29 (38%)
		fn3	445..516	CDD:278470	7/15 (47%)
		fn3	542..625	CDD:278470
		FN3	638..730	CDD:238020
		PTKc_Tie2	815..1117	CDD:133219
		STYKc	823..1091	CDD:214568
drpr	NP_001261276.1	EMI	27..92	CDD:284877
		EGF_CA	274..319	CDD:304395
		DSL	<479..518	CDD:302925	14/38 (37%)
		DSL	<567..606	CDD:302925	9/38 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900