DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tek and Dscam1

DIOPT Version :9

Sequence 1:	NP_038718.2	Gene:	Tek / 21687	MGIID:	98664	Length:	1123	Species:	Mus musculus
Sequence 2:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster

Alignment Length:	1162	Identity:	223/1162 - (19%)
Similarity:	379/1162 - (32%)	Gaps:	297/1162 - (25%)

- Green bases have known domain annotations that are detailed below.

Mouse     6 GLVLCGVSLLLYGVVEGAMDLILINSLPLVSDAETS---------LTCIASGWHPHEPITIGRDF 61
            ||..| ::....||.|.:..| .:..||.:...|..         :||..:| :|.:.|...||.
  Fly   506 GLYKC-IAKSKVGVAEHSAKL-NVYGLPYIRQMEKKAIVAGETLIVTCPVAG-YPIDSIVWERDN 567

Mouse    62 EALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFC-----EGRVRGQAIRIRTMKMRQQ 121
            .||      |:...|.|.....  ::.:..:.:.....|.|     ||.....::.::.|.:.|
  Fly   568 RAL------PINRKQKVFPNGT--LIIENVERNSDQATYTCVAKNQEGYSARGSLEVQVMVLPQ- 623

Mouse   122 ASFLPATLTMTVDRGDNVNISFKKVLIKEEDAVIYKNGSFIHSV---------PRHEVPDILE-- 175
              .:|......::.||::::..:   |::.|..|..:.||..|.         |:.....|.|
  Fly   624 --IVPFAYEDLINMGDSIDLFCQ---IQKGDRPIKVHWSFERSAGDYGFDQVQPQMRTNRISEKT 683

Mouse   176 --VHLPHAQPQDAG---VYSARYIGGNLFTSAFTRLIVRRCEAQKWGPDCSRPCTTCKNNGVCHE 235
              :.:|.|.|...|   ..::...|...::...|..:
  Fly   684 SMISIPSASPAHTGRDTCIASNKAGTTTYSVDLTVNV---------------------------- 720

Mouse   236 DTGECICPPGFMGRTCEKACEPHTFGRTCKERCSG-----PE-GCKSYVFCLPDPY-------GC 287
                   ||.::....:||   ...|...|..|..     |: ..|..|...|..|       ..
  Fly   721 -------PPRWILEPTDKA---FAQGSDAKVECKADGFPKPQVTWKKAVGDTPGEYKDLKKSDNI 775

Mouse   288 SCATGWRGLQCNEACPSGYYGPDCKLRCHCTNEEICDRFQGCLCSQGWQG-LQCEKEGRPRMTPQ 351
            ....|...:...:....|||              :|:...|  ...|... :....:..|..|.:
  Fly   776 RVEEGTLHVDNIQKTNEGYY--------------LCEAING--IGSGLSAVIMISVQAPPEFTEK 824

Mouse   352 IEDLPDHIEVNSGKFNPI---CKASGWPLPTSEEMTLVKPDGTV-------LQP-NDFNYTDRFS 405
            :.:      ..:.:..|.   |:|.|           .||.|.:       |.| ||..||.|..
  Fly   825 LRN------QTARRGEPAVLQCEAKG-----------EKPIGILWNMNNMRLDPKNDNRYTIREE 872

Mouse   406 V------AIFTVNRVLPPDSGVWVCSVNTVAGMVEKPFNISVKVLPEPLHAPNVID-TGHNFAII 463
            :      :..::.|....||.::.|......|..:...|:.|:.:||..:|..|:| :|.:   :
  Fly   873 ILSTGVMSSLSIKRTERSDSALFTCVATNAFGSDDASINMIVQEVPEMPYALKVLDKSGRS---V 934

Mouse   464 NIS-SEPYFGDGPIKSKKLFYKPVNQAWKYIE------VTNEIFTLNYLEPRTDYELCVQLARPG 521
            .:| ::||.|:.|:....:.:|....:|..|:      .|.|. .:..|.|.|.|.:.: :|...
  Fly   935 QLSWAQPYDGNSPLDRYIIEFKRSRASWSEIDRVIVPGHTTEA-QVQKLSPATTYNIRI-VAENA 997

Mouse   522 EGGEGHPGPVRRFTTASIGLPPPRGLSLLPKSQTALNLTWQP---IFTNSED-EFYVEVERRSLQ 582
            .|.......|...|........|:.:.:.|.:||.:.:||:|   ...|.|. .:||..:..:..
  Fly   998 IGTSQSSEAVTIITAEEAPSGKPQNIKVEPVNQTTMRVTWKPPPRTEWNGEILGYYVGYKLSNTN 1062

Mouse   583 TTSDQQNIKV---PGNLTSVLLSNLVPREQYTVRARV-NTKAQGEWSEELRAWTLSDILPPQPEN 643
            ::...:.|..   .|...::.|.||....||:|..:. |....|..|||.:.:|........|.:
  Fly  1063 SSYVFETINFITEEGKEHNLELQNLRVYTQYSVVIQAFNKIGAGPLSEEEKQFTAEGTPSQPPSD 1127

Mouse   644 IKISNITDSTAMVSWTIVDGYSISSIIIRYKVQGKNEDQHIDV---KIKNATVTQYQLKGLEPET 705
            ...:.:|..|..|.|......|.:.:|..|||.....|:..|.   ..|....:...|.||:..|
  Fly  1128 TACTTLTSQTIRVGWVSPPLESANGVIKTYKVVYAPSDEWYDETKRHYKKTASSDTVLHGLKKYT 1192

Mouse   706 TYHVDIFAENNIGSSNPAFSHELRTLPHSP-ASADLGGGKMLLIAILGSAGMTCITVLLAFLIML 769
            .|.:.:.|....|....:.....:|.|..| |..|:   |.|   ::|:|     .:|:::....
  Fly  1193 NYTMQVLATTAGGDGVRSVPIHCQTEPDVPEAPTDV---KAL---VMGNA-----AILVSWRPPA 1246

Mouse   770 QLKRANVQRRMAQAFQNVREEPAVQ--------FNSGTLALNRKAKNNPDPTIYPVLDWNDIKFQ 826
            |......|..:....:....|...|        |.:..|..|:           |...|  :...
  Fly  1247 QPNGIITQYTVYSKAEGAETETKTQKVPHYQMSFEATELEKNK-----------PYEFW--VTAS 1298

Mouse   827 DVIGEG-------------------NFGQVLKARIKKD--------GLRMDAAIKRMK--EYASK 862
            ..||||                   :|.....|..|:|        |........::|  |:::.
  Fly  1299 TTIGEGQQSKSIVAMPSDQVPAKIASFDDTFTATFKEDAKMPCLAVGAPQPEITWKIKGVEFSAN 1363

Mouse   863 DD--------------HRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNL---- 909
            |.              :|..||:..  |   |..|.| ...:..|: .:.||...:||..|
  Fly  1364 DRMRVLPDGSLLIKSVNRQDAGDYS--C---HAENSI-AKDSITHK-LIVLAPPQSPHVTLSATT 1421

Mouse   910 ---LDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVAR------GMDYLSQKQFIHRDLA 965
               |....|....:|.|.....            ||:..:...      .:|  |||..|
  Fly  1422 TDALTVKLKPHEGDTAPLHGYT------------LHYKPEFGEWETSEVSVD--SQKHNI----- 1467

Mouse   966 ARNILVGENYIAKIADF---GLSRGQEVYVKKTMGRLP-----VRWMAIESLNYSVY 1014
             ..:|.|..|......|   |.....::...:|.|:.|     .|::.:.|.:.|::
  Fly  1468 -EGLLCGSRYQVYATGFNNIGAGEASDILNTRTKGQKPKLPEKPRFIEVSSNSVSLH 1523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tek	NP_038718.2	Ig_Tie2_1	24..118	CDD:287411	21/107 (20%)
		EGF_Lam	230..275	CDD:238012	8/50 (16%)
		EGF_2	311..340	CDD:285248	3/29 (10%)
		fn3	445..516	CDD:278470	20/78 (26%)
		fn3	542..625	CDD:278470	21/90 (23%)
		FN3	638..730	CDD:238020	20/94 (21%)
		PTKc_Tie2	815..1117	CDD:133219	49/264 (19%)
		STYKc	823..1091	CDD:214568	47/256 (18%)
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653
		Ig	269..340	CDD:143165
		IG_like	353..425	CDD:214653
		IGc2	361..413	CDD:197706
		I-set	433..527	CDD:254352	7/22 (32%)
		IGc2	446..517	CDD:197706	3/11 (27%)
		I-set	533..618	CDD:254352	17/93 (18%)
		IGc2	544..607	CDD:197706	14/71 (20%)
		Ig	641..714	CDD:143165	14/75 (19%)
		IGc2	735..804	CDD:197706	14/84 (17%)
		I-set	819..914	CDD:254352	22/111 (20%)
		Ig	833..921	CDD:299845	23/98 (23%)
		FN3	918..1011	CDD:238020	23/97 (24%)
		FN3	1018..1116	CDD:238020	24/97 (25%)
		FN3	1124..1217	CDD:238020	20/92 (22%)
		FN3	1222..1312	CDD:238020	21/113 (19%)
		Ig	1339..1406	CDD:299845	12/73 (16%)
		FN3	1409..1499	CDD:238020	19/109 (17%)
		FN3	1504..1584	CDD:238020	4/20 (20%)
		Dscam_C	1890..2008	CDD:289151
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000