DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tead4 and sd

DIOPT Version :9

Sequence 1:	NP_035697.3	Gene:	Tead4 / 21679	MGIID:	106907	Length:	427	Species:	Mus musculus
Sequence 2:	NP_001368984.1	Gene:	sd / 32536	FlyBaseID:	FBgn0003345	Length:	747	Species:	Drosophila melanogaster

Alignment Length:	444	Identity:	255/444 - (57%)
Similarity:	302/444 - (68%)	Gaps:	82/444 - (18%)

- Green bases have known domain annotations that are detailed below.

Mouse     7 SSPDSPEGSSISGGSQALDKPID-------------NDAEGVWSPEIERSFQEALAIYPPCGRRK 58
            :.|....||:.:.||....|.:|             .||||||||:||:||||||:|||||||||
  Fly    51 AGPPGALGSADTNGSMVDSKNLDVGDMSDDEKDLSSADAEGVWSPDIEQSFQEALSIYPPCGRRK 115

Mouse    59 IILTEEGKMYGRNELIARHIKLRTGKTRTRKQVSSHIQVLARRKAREIQAKLKDQAAKNKALQSM 123
            |||::|||||||||||||:|||||||||||||||||||||||||.||||||:|.|
  Fly   116 IILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKLREIQAKIKVQ---------- 170

Mouse   124 AAMSSAQIVSATAFHSKMALARGPGYPAISGFWQGALPG-QPGTSHDVKPFSQNTYPVQPPLPLP 187
                                           |||   || ||.||.|:|||.|..|
  Fly   171 -------------------------------FWQ---PGLQPSTSQDIKPFPQPPY--------- 192

Mouse   188 GFESPAGPTPSPSA-------PLAPPWQGRSIASSKLWMLEFSAFLERQQDPDTYNKHLFVHISQ 245
                |||.|.:..:       |...||:||:||:.|..:|||:||:|.|:| :.|::||||.:.
  Fly   193 ----PAGKTSTAVSGDETGIPPSQLPWEGRAIATHKFRLLEFTAFMEIQRD-EIYHRHLFVQLG- 251

Mouse   246 SSPSYSDPYLETVDIRQIYDKFPEKKGGLKELFERGPSNAFFLVKFWADLNTNI--DDEGSAFYG 308
            ..||:|||.|||||||||:||||||.||||:|:|:||.|||:|||.||||||::  ..|...|||
  Fly   252 GKPSFSDPLLETVDIRQIFDKFPEKSGGLKDLYEKGPQNAFYLVKCWADLNTDLTTGSETGDFYG 316

Mouse   309 VSSQYESPENMIITCSTKVCSFGKQVVEKVETEYARYENGHYLYRIHRSPLCEYMINFIHKLKHL 373
            |:|||||.||:::.|||.|||||||||||||:||:|.||..|:|||.|||:||||||||.|||:|
  Fly   317 VTSQYESNENVVLVCSTIVCSFGKQVVEKVESEYSRLENNRYVYRIQRSPMCEYMINFIQKLKNL 381

Mouse   374 PEKYMMNSVLENFTILQVVTNRDTQETLLCIAYVFEVSASEHGAQHHIYRLVKE 427
            ||:|||||||||||||||:..|:||||||||||||||:|...|..||||||:||
  Fly   382 PERYMMNSVLENFTILQVMRARETQETLLCIAYVFEVAAQNSGTTHHIYRLIKE 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tead4	NP_035697.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32		7/37 (19%)
		TEA	31..98	CDD:128703	60/66 (91%)
		Nuclear localization signal. /evidence=ECO:0000255	78..94		15/15 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	163..206		15/49 (31%)
sd	NP_001368984.1	TEA	88..155	CDD:128703	60/66 (91%)
sd	NP_001368984.1	YBD	224..432	CDD:407601	144/209 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847737
Domainoid	1	1.000	298	1.000	Domainoid score	I1450
eggNOG	1	0.900	-	-		E1_KOG3841
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	465	1.000	Inparanoid score	I1528
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52403
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001013
OrthoInspector	1	1.000	-	-		otm43938
orthoMCL	1	0.900	-	-		OOG6_103264
Panther	1	1.100	-	-	LDO	PTHR11834
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X674
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760