DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tead3 and sd

DIOPT Version :9

Sequence 1:	NP_001091696.2	Gene:	Tead3 / 21678	MGIID:	109241	Length:	465	Species:	Mus musculus
Sequence 2:	NP_001368984.1	Gene:	sd / 32536	FlyBaseID:	FBgn0003345	Length:	747	Species:	Drosophila melanogaster

Alignment Length:	470	Identity:	257/470 - (54%)
Similarity:	304/470 - (64%)	Gaps:	94/470 - (20%)

- Green bases have known domain annotations that are detailed below.

Mouse    16 GSGPEPKATSTIASNSWT-ANSSP----GEAREDGSEGLDKGLD-------------NDAEGVWS 62
            |:.|.|          || .|:.|    |.|..:||....|.||             .|||||||
  Fly    40 GTIPSP----------WTPVNAGPPGALGSADTNGSMVDSKNLDVGDMSDDEKDLSSADAEGVWS 94

Mouse    63 PDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARKK 127
            |||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||:|
  Fly    95 PDIEQSFQEALSIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRK 159

Mouse   128 VREYQVGIKAMNLDQVSKDKALQSMASMSSAQIVSASVLQNKFSPPSPLPQAVFSSSSRFWSSPP 192
            :||.|..||.                                                :||..
  Fly   160 LREIQAKIKV------------------------------------------------QFWQP-- 174

Mouse   193 LLGQQPGPSQDIKPFAQPAYPIQPPLPPALNSYESLAPLPPAAASATASAPAWQDRTIASSRLRL 257
              |.||..|||||||.||.|| ......|::..|:  .:||       |...|:.|.||:.:.||
  Fly   175 --GLQPSTSQDIKPFPQPPYP-AGKTSTAVSGDET--GIPP-------SQLPWEGRAIATHKFRL 227

Mouse   258 LEYSAFMEVQRDPDTYSKHLFVHIGQTNPAFSDPPLEAVDVRQIYDKFPEKKGGLKELYEKGPPN 322
            ||::||||:||| :.|.:||||.:| ..|:||||.||.||:|||:||||||.||||:||||||.|
  Fly   228 LEFTAFMEIQRD-EIYHRHLFVQLG-GKPSFSDPLLETVDIRQIFDKFPEKSGGLKDLYEKGPQN 290

Mouse   323 AFFLVKFWADLNSTIQEG--PGAFYGVSSQYSSADSMTISVSTKVCSFGKQVVEKVETEYARLEN 385
            ||:|||.|||||:.:..|  .|.||||:|||.|.:::.:..||.|||||||||||||:||:||||
  Fly   291 AFYLVKCWADLNTDLTTGSETGDFYGVTSQYESNENVVLVCSTIVCSFGKQVVEKVESEYSRLEN 355

Mouse   386 GRFVYRIHRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTSRDSQETLLVIAFVFEVST 450
            .|:||||.||||||||||||.|||:|||:|||||||||||||||:.:|::|||||.||:||||:.
  Fly   356 NRYVYRIQRSPMCEYMINFIQKLKNLPERYMMNSVLENFTILQVMRARETQETLLCIAYVFEVAA 420

Mouse   451 SEHGAQHHVYKLVKD 465
            ...|..||:|:|:|:
  Fly   421 QNSGTTHHIYRLIKE 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tead3	NP_001091696.2	TEA	56..123	CDD:128703	65/66 (98%)
sd	NP_001368984.1	TEA	88..155	CDD:128703	65/66 (98%)
sd	NP_001368984.1	YBD	224..432	CDD:407601	141/209 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847738
Domainoid	1	1.000	298	1.000	Domainoid score	I1450
eggNOG	1	0.900	-	-		E1_KOG3841
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	465	1.000	Inparanoid score	I1528
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52403
OrthoDB	1	1.010	-	-		D355519at33208
OrthoFinder	1	1.000	-	-		FOG0001013
OrthoInspector	1	1.000	-	-		otm43938
orthoMCL	1	0.900	-	-		OOG6_103264
Panther	1	1.100	-	-	O	PTHR11834
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2507
SonicParanoid	1	1.000	-	-		X674
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.800