DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tead2 and sd

DIOPT Version :9

Sequence 1:	NP_001272427.1	Gene:	Tead2 / 21677	MGIID:	104904	Length:	445	Species:	Mus musculus
Sequence 2:	NP_001368984.1	Gene:	sd / 32536	FlyBaseID:	FBgn0003345	Length:	747	Species:	Drosophila melanogaster

Alignment Length:	451	Identity:	235/451 - (52%)
Similarity:	285/451 - (63%)	Gaps:	82/451 - (18%)

- Green bases have known domain annotations that are detailed below.

Mouse    16 WTGSEEGSEEGTGGSEGVG----------GD--------GSPDAEGVWSPDIEQSFQEALAIYPP 62
            ||....|.....|.::..|          ||        .|.||||||||||||||||||:||||
  Fly    46 WTPVNAGPPGALGSADTNGSMVDSKNLDVGDMSDDEKDLSSADAEGVWSPDIEQSFQEALSIYPP 110

Mouse    63 CGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSREIQSKLKDQVSKDK 127
            |||||||||||||||||||||||||||||||||||||||||||||||||.||||:|:|
  Fly   111 CGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKLREIQAKIK------- 168

Mouse   128 AFQTMATMSSAQLISAPSLQAKLGPSGPQATELFQFWSGSSGPPWNVPDVKPFSQAPFSVSLTPP 192
                                             .|||.....|..: .|:|||.|.|:....|..
  Fly   169 ---------------------------------VQFWQPGLQPSTS-QDIKPFPQPPYPAGKTST 199

Mouse   193 A--SDLPGYEPPPALSPLPPPAPSPPAWQARALGTARLQLIEFSAFVE-PPDAVDSFQRHLFVHI 254
            |  .|..|..|    |.||        |:.||:.|.:.:|:||:||:| ..|.:  :.|||||.:
  Fly   200 AVSGDETGIPP----SQLP--------WEGRAIATHKFRLLEFTAFMEIQRDEI--YHRHLFVQL 250

Mouse   255 SQQCPSPGAPPLESVDVRQIYDKFPEKKGGLRELYDRGPPHAFFLVKFWADLNWGPSAEEAGSSG 319
            ..: ||...|.||:||:|||:||||||.|||::||::||.:||:|||.|||||     .:..:..
  Fly   251 GGK-PSFSDPLLETVDIRQIFDKFPEKSGGLKDLYEKGPQNAFYLVKCWADLN-----TDLTTGS 309

Mouse   320 GGGGFYGVSSQYESRELMTLTCSSKVCSFGKQVVEKVETERAQLEDGRFVYRLLRSPMCEYLVNF 384
            ..|.||||:|||||.|.:.|.||:.|||||||||||||:|.::||:.|:|||:.|||||||::||
  Fly   310 ETGDFYGVTSQYESNENVVLVCSTIVCSFGKQVVEKVESEYSRLENNRYVYRIQRSPMCEYMINF 374

Mouse   385 LHKLRQLPERYMMNSVLENFTILQVVTNRDTQELLLCTAYVFEVSTSERGAQYHIYRLVRD 445
            :.||:.|||||||||||||||||||:..|:|||.|||.||||||:....|..:|||||:::
  Fly   375 IQKLKNLPERYMMNSVLENFTILQVMRARETQETLLCIAYVFEVAAQNSGTTHHIYRLIKE 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tead2	NP_001272427.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47		14/48 (29%)
		TEA	40..107	CDD:128703	65/66 (98%)
		Transcriptional activation. /evidence=ECO:0000255	172..445		146/275 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	191..217		7/27 (26%)
		YBD	226..442	CDD:407601	126/216 (58%)
sd	NP_001368984.1	TEA	88..155	CDD:128703	65/66 (98%)
sd	NP_001368984.1	YBD	224..432	CDD:407601	126/215 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	298	1.000	Domainoid score	I1450
eggNOG	1	0.900	-	-		E1_KOG3841
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	465	1.000	Inparanoid score	I1528
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52403
OrthoDB	1	1.010	-	-		D355519at33208
OrthoFinder	1	1.000	-	-		FOG0001013
OrthoInspector	1	1.000	-	-		otm43938
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11834
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2507
SonicParanoid	1	1.000	-	-		X674
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.970