DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sry and cic

DIOPT Version :10

Sequence 1:NP_035694.1 Gene:Sry / 21674 MGIID:98660 Length:395 Species:Mus musculus
Sequence 2:NP_001262755.1 Gene:cic / 53560 FlyBaseID:FBgn0262582 Length:2150 Species:Drosophila melanogaster


Alignment Length:297 Identity:82/297 - (27%)
Similarity:110/297 - (37%) Gaps:112/297 - (37%)


- Green bases have known domain annotations that are detailed below.


Mouse   145 QQQQQQQQQQF----------------------------HNHHQQQQQFYDHHQQQQQQQQQQQQ 181
            :||||||||.|                            .:...||      |||.||||||||.
  Fly    31 KQQQQQQQQVFVVAANKMVIPATGATIAGIPTATTTAAAESTATQQ------HQQHQQQQQQQQH 89

Mouse   182 FHDHHQQKQQFHDHHQ------------QQQQFHDHHHHHQEQQFHDHHQQQQQFHDHQQQQQQ- 233
            .        .|..|.|            ||||......|.::::|......:.:.|..|||||| 
  Fly    90 V--------LFQPHLQTTTATAATCSTPQQQQPPQPRQHPKKRKFDPAELDKTEQHPQQQQQQQV 146

Mouse   234 --QQQQQ----------FHDHHQQKQQF------------HDHHHHQQQQQFHDHQQQQQQFHDH 274
              |:||:          ..:.:||.:..            :....:.......|.:|||||....
  Fly   147 SLQKQQKPAETTGNGDGLANGNQQHRMIVSCGAGAGNNSSNSSSSNNSSHSSSDIKQQQQQRIII 211

Mouse   275 QQQQH----QFHDHPQQKQQFH----DHPQQQQQFHDH----HHQQQQKQQFHDHHQQKQQFHDH 327
            ...||    .:..|.......|    :|   ||:.|..    ::||||:|      ||:||    
  Fly   212 ASPQHASGSTYKQHVASGNNSHAATINH---QQRTHTPTTAVYYQQQQQQ------QQQQQ---- 263

Mouse   328 HQQKQQFHDHHQQQQQFHDHHQQQQQQQQQQQQQFHD 364
             ||:..|:.::||       |.|:|.|||||||...|
  Fly   264 -QQRFSFNSNNQQ-------HLQEQHQQQQQQQSLLD 292

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SryNP_035694.1 Sufficient for interaction with KPNB1. /evidence=ECO:0000250|UniProtKB:Q05066 4..81
HMG-box_SoxA_SoxB_SoxG 4..79 CDD:438837
Required for nuclear localization. /evidence=ECO:0000250|UniProtKB:Q05066 6..22
Sufficient for interaction with EP300. /evidence=ECO:0000250|UniProtKB:Q05066 52..84
Required for nuclear localization. /evidence=ECO:0000250|UniProtKB:Q05066 75..81
Necessary for interaction with ZNF208 isoform KRAB-O. /evidence=ECO:0000269|PubMed:15469996 92..144
Necessary for interaction with SLC9A3R2 and nuclear accumulation of SLC9A3R2. /evidence=ECO:0000269|PubMed:16166090 94..138
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 142..361 80/292 (27%)
cicNP_001262755.1 DUF4819 349..432 CDD:465014
HMG-box_CIC-like 1231..1308 CDD:438806
Blue background indicates that the domain is not in the aligned region.

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