DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sry and Sox15

DIOPT Version :9

Sequence 1:NP_035694.1 Gene:Sry / 21674 MGIID:98660 Length:395 Species:Mus musculus
Sequence 2:NP_523739.2 Gene:Sox15 / 36575 FlyBaseID:FBgn0005613 Length:784 Species:Drosophila melanogaster


Alignment Length:90 Identity:44/90 - (48%)
Similarity:68/90 - (75%) Gaps:2/90 - (2%)


- Green bases have known domain annotations that are detailed below.


Mouse     2 EGHVKRPMNAFMVWSRGERHKLAQQNPSMQNTEISKQLGCRWKSLTEAEKRPFFQEAQRLKILHR 66
            |..::|||||||||::.||.|||.:||.:.|.::||.||.:|:|||..::||:.:||:||:::|.
  Fly   212 ESRIRRPMNAFMVWAKIERKKLADENPDLHNADLSKMLGKKWRSLTPQDRRPYVEEAERLRVIHM 276

Mouse    67 EKYPNYKYQPHRRAKVSQRSGILQP 91
            .::|||||:|.||.:...|:  :||
  Fly   277 TEHPNYKYRPRRRKQSKLRA--MQP 299

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SryNP_035694.1 Sufficient for interaction with KPNB1. /evidence=ECO:0000250|UniProtKB:Q05066 4..81 40/76 (53%)
SOX-TCF_HMG-box 4..74 CDD:238684 35/69 (51%)
Required for nuclear localization. /evidence=ECO:0000250|UniProtKB:Q05066 6..22 11/15 (73%)
Sufficient for interaction with EP300. /evidence=ECO:0000250|UniProtKB:Q05066 52..84 15/31 (48%)
Required for nuclear localization. /evidence=ECO:0000250|UniProtKB:Q05066 75..81 3/5 (60%)
Necessary for interaction with ZNF208 isoform KRAB-O. /evidence=ECO:0000269|PubMed:15469996 92..144 44/90 (49%)
Necessary for interaction with SLC9A3R2 and nuclear accumulation of SLC9A3R2. /evidence=ECO:0000269|PubMed:16166090 94..138
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 142..361
Sox15NP_523739.2 SOX-TCF_HMG-box 214..285 CDD:238684 36/70 (51%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167838582
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0527
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000028
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10270
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.840

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