Protein Alignment FAAH and CG5191

DIOPT Version :9

• Sequence 1: NP_001432.2
• Gene: FAAH / 2166
• HGNCID: 3553
• Length: 579
• Species: Homo sapiens
• Sequence 2: NP_650893.2
• Gene: CG5191 / 42431
• FlyBaseID: FBgn0038803
• Length: 552
• Species: Drosophila melanogaster
• Alignment Length: 574
• Identity: 142/574 - (24%)
• Similarity: 216/574 - (37%)
• Gaps: 164/574 - (28%)

Human    63 RLQNPDLDSEALLALPLPQLVQKLHSRELAPEAVLFTYVGKAWEVNKGTNCVTSYLADCETQLSQ 127
            |.:.|.:.|. ||.:|...|.:.:.:|::..|.|:..|:.:..:||...|.:..  ...|..|.:
  Fly    53 RRKLPPIRSH-LLEIPAVDLAKLIRTRKIKSEEVVEAYIERCRQVNPLINAIVQ--DRFEEALEE 114

Human   128 APR------QGL-----------LYGVPVSLKECFTYKGQDSTLGLSLNEGVPAECDSVVVHVLK 175
            |..      .|:           |.|:||::||....||..:..|........|:.|:.||..:|
  Fly   115 AREIDNVIAMGINSVESMEELTPLLGIPVTVKESIAVKGMTNQAGRVFKTPQIAKSDAPVVEQIK 179

Human   176 LQGAVPFVHTNVPQSMFSYDCSNPLFGQTVNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGG 240
            ..|.:..:.:|.|:....::..|.:.|||.||:...::||||||||.||:.||.|.|||.:||||
  Fly   180 RSGGIILLVSNTPELCLLWETYNNVTGQTKNPYDLKRTPGGSSGGEAALLASGASLLGLTSDIGG 244

Human   241 SIRFPSSFCGICGLKPTGNRLSKSGLKG----CVYGQEAVRLSVGPMARDVESLALCLRALLCED 301
            |.|.|:.|.||.|.|||...:|   .||    ..:.:.....::.||.|..:.|.|.|:.:
  Fly   245 SSRLPAMFSGIWGHKPTPYAVS---FKGHHPTSDFPKWGDFFTIAPMTRYAKDLPLLLKCM---- 302

Human   302 MFRLDPTVPPLPFREEVYTSSQPLRVG---YYETDNYTMPSPAMR-------------------- 343
               .|||.|.|       |..:|:.|.   ::..|| ..||..||
  Fly   303 ---SDPTGPKL-------TLDRPISVNGIRFFFMDN-DGPSGMMRPLSRDLHAAINRVATDFNAK 356

Human   344 --------------RAVLETKQSLEAAGH-TLVPFLPSNIPHALETLSTGGLFSDG-------GH 386
                          .:.:.|.:::|...| |.....|..:  ..||:......||.       ||
  Fly   357 RVNIRKMKWSLDISLSAMLTMKNIETIYHKTEEGEQPKTV--CKETVKYFFGCSDSILPSVIFGH 419

Human   387 TFLQNFKGDFVDPCLGDLVSILKLPQWLKGLLAFLVKPLLPRLSAFLSNMKSRSAGKLWELQHEI 451
              ||||.....:.....|.||::       .|....|.:|.....||......:|.:.:::.|::
  Fly   420 --LQNFMKIIPNSRHKHLASIIE-------ALKTEFKEMLGNDGVFLYPTFPNTAHQHYQIYHKL 475

Human   452 EVYRKTVIAQWRALDLDVVLTPMLAPALDLNAPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAED 516
                               |.||                  |..::|.|.     :|||....
  Fly   476 -------------------LEPM------------------YMAIFNTLG-----LPVTNCMI-- 496

Human   517 EAQMEHYRGYFGDIWDKMLQKGMKKSVGLPVAVQCVALPWQEELCLRFMREVER 570
                                 |:.:. .||:.:|.||.|.|:.|.|...||:||
  Fly   497 ---------------------GLDRR-NLPMGIQVVANPGQDHLSLAVAREMER 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FAAH	NP_001432.2	Amidase	95..562	CDD:279733	128/532 (24%)
		Substrate binding. /evidence=ECO:0000250	238..241		2/2 (100%)
CG5191	NP_650893.2	GatA	61..537	CDD:223232	140/566 (25%)
		PRK07488	63..537	CDD:236030	139/563 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0154
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.69812	Normalized mean entropy	S4795
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D852596at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1914
SonicParanoid	1	1.000	-	-		X256
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.800