DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Slc5a8 and CG33124

DIOPT Version :9

Sequence 1:	NP_663398.2	Gene:	Slc5a8 / 216225	MGIID:	2384916	Length:	611	Species:	Mus musculus
Sequence 2:	NP_001097056.3	Gene:	CG33124 / 318891	FlyBaseID:	FBgn0053124	Length:	588	Species:	Drosophila melanogaster

Alignment Length:	609	Identity:	201/609 - (33%)
Similarity:	326/609 - (53%)	Gaps:	71/609 - (11%)

- Green bases have known domain annotations that are detailed below.

Mouse     1 MDASRDIGSFVVWDYVVFAGMLLISAAIGIYY--------------------AFAGGGQQTSKDF 45
            ||..|    |...||.||.|:.::|.|||:|:                    :....|.:...::
  Fly     1 MDTYR----FGTVDYTVFLGVTILSIAIGLYFGWIKKTKKEMESSPADTPEISIPNFGSKKMNEY 61

Mouse    46 LMGGRSMSAVPVALSLTASFMSAVTVLGTPAEVYRFGAIFSIFVITYFFVVVISAEVFLPVFYRL 110
            |||...:...|||:||.|||:|.|.:||.|:|:|.:|..:|:.|:......:..:.::||||..|
  Fly    62 LMGSGHLKVFPVAMSLIASFISGVAILGNPSEIYYYGTQYSLIVLAIVIQGLAVSYIYLPVFSAL 126

Mouse   111 GITSTYEYLELRFNRCIRLCGTILFIVQTILYTGIVIYAPALALNQVTGFDLWGAVVATGVVCTF 175
            .:.|:||||.:||:..||...:|:|:::.:|||..|::.|||||||.:|.::....|...|||..
  Fly   127 QVRSSYEYLGMRFHPLIRNIVSIMFVIEVLLYTPFVVFVPALALNQASGLNIHMIEVLIIVVCVI 191

Mouse   176 YCTLGGLKAVVWTDVFQVGIMVAGFASVIIQASITQHGINKILSDAF----NGGRLNFWNFDPNP 236
            |..||||||||.||::||.||   ||||::.|.:....|.. |.|.|    :||||.|.|.:|:|
  Fly   192 YTLLGGLKAVVHTDIWQVVIM---FASVVVVAILATCYITD-LDDFFESLVDGGRLIFGNINPSP 252

Mouse   237 LQRHTFWTIVIGGTFTWTTIYGVNQSQVQRYISCKSRLHAKLSLYVNLVGLWVILTCSIFCGLAL 301
            ..|:|.|::||||.|.||:|..|:|:.|.||:|..:...|:.|:...::|..:..:...|.||.:
  Fly   253 YVRNTVWSVVIGGAFYWTSITAVHQTMVHRYMSLPNLKMARTSIAFFVLGSIIFYSVLSFLGLLI 317

Mouse   302 YSRYRECDPWTSKKVSAIDQLMPYLVLDILKNYPGVPGLFVACAYSGTLSTVSSSINALAAVTVE 366
            ::.|::|||.::.::...|||:|..|:..:.:..|:||||:|..:...||::|..:|:.:.|.::
  Fly   318 FNMYKDCDPLSAGQIMNNDQLVPLFVVQSVGHIYGIPGLFIAGIFGAGLSSLSVFLNSTSLVILQ 382

Mouse   367 DLIKPRFK-SLSEKSLSWISQGMSVLYGALCIGMAALASLMGALLQAALSIFGMVGGPLLGLFSL 430
            |:::..|| ...|.:.:.|.:...|:.|||..|...|...:..:|...:|:..:......|:|:|
  Fly   383 DIVRGCFKMQPGETASAIIVKATIVIMGALVFGEVLLLEKVSGILSICMSLVAIATSSTFGIFTL 447

Mouse   431 GILVPFANSIGALTGLLAGFAISLWVGIGAQLYP---PLPERTLPLPLETYGCNITHNGSDWMST 492
            .:|||:||::|...|.:|||.::.|:..|:|:..   .|....||:.:.:...|:|...:.|:..
  Fly   448 AVLVPWANTVGTAVGGIAGFLLTGWITFGSQIAAASGQLHHHRLPVSVASCPGNVTARENVWVDE 512

Mouse   493 TEMPFSTSAFQIHNAERTPLMDNWYSLSYLYFSTIGTLTTLFVGILISLSTGGRK-QNLDP---- 552
            .::              .||    :.||:.:.:.||.||.:.||.|:||.|.... ::||.
  Fly   513 EQV--------------FPL----FRLSFHWINPIGALTVVVVGSLVSLVTKPTDIKSLDSDLIS 559

Mouse   553 ----RFLLTKQDFLSNFDVFKKRN 572
                |||..        :.||:||
  Fly   560 PVIHRFLPK--------ECFKQRN 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc5a8	NP_663398.2	SLC5sbd_SMCT1	7..549	CDD:271402	189/570 (33%)
CG33124	NP_001097056.3	SLC5sbd_NIS-SMVT	9..533	CDD:271383	180/545 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836528
Domainoid	1	1.000	46	1.000	Domainoid score	I12033
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4891
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.800