DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Slc5a8 and CG31262

DIOPT Version :9

Sequence 1:	NP_663398.2	Gene:	Slc5a8 / 216225	MGIID:	2384916	Length:	611	Species:	Mus musculus
Sequence 2:	NP_001138069.2	Gene:	CG31262 / 318649	FlyBaseID:	FBgn0051262	Length:	579	Species:	Drosophila melanogaster

Alignment Length:	566	Identity:	177/566 - (31%)
Similarity:	292/566 - (51%)	Gaps:	51/566 - (9%)

- Green bases have known domain annotations that are detailed below.

Mouse     1 MDASRDIGSFVVWDYVVFAGMLLISAAIGIYYAF-----------------AGGGQQTSKDFLMG 48
            ||..|    |...||:|...|.|:|...|||:..                 ...|.:...::|||
  Fly     1 MDNYR----FGTVDYLVLVAMTLLSTGTGIYFGALKKKHKNKKSVSEDNRRTNFGSEKIDEYLMG 61

Mouse    49 GRSMSAVPVALSLTASFMSAVTVLGTPAEVYRFGAIFSIFVITYFFVVVISAEVFLPVFYRLGIT 113
            .|:|..:||:::|    ....:::|||:|:|.:|..:.:.::......:..:.|:|||:..|.|.
  Fly    62 SRNMKVIPVSITL----YRVTSIIGTPSEIYHYGTQYYLIIVAIILQGIAFSYVYLPVYSALQIG 122

Mouse   114 STYEYLELRFNRCIRLCGTILFIVQTILYTGIVIYAPALALNQVTGFD--LWGAVVATGVVCTFY 176
            |.||||.||||..||...:.:::...:.|...::|.|||:|:||:|.:  |.|.|:.  :.|..|
  Fly   123 SAYEYLGLRFNSIIRTTASFMYVFGILTYLPFIVYVPALSLSQVSGLNTHLIGLVII--LACVTY 185

Mouse   177 CTLGGLKAVVWTDVFQVGIMVAGFASVIIQASITQHGINKILSDAFNGGRLNFWNFDPNPLQRHT 241
            ..:|||||||.|||:||.:|.....:|...|....:|:..:..||..||||...|.:|:|..|||
  Fly   186 TFMGGLKAVVHTDVWQVAVMFLSLVAVAFLAIYYSNGLVAVFDDAEQGGRLMLANTNPSPYVRHT 250

Mouse   242 FWTIVIGGTFTWTTIYGVNQSQVQRYISCKSRLHAKLSLYVNLVGLWVILTCSIFCGLALYSRYR 306
            .|:::|||...||::....|..||||:|..|...::.:.::..:|:.:.:....|.||.|:|:|:
  Fly   251 VWSVLIGGFSFWTSVNAGGQHMVQRYMSLPSLKKSRQASFIFTIGVSIFIALCCFMGLLLFSKYK 315

Mouse   307 ECDPWTSKKVSAIDQLMPYLVLDILKNYPGVPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKP 371
            :|||.::..:...|||:|..|:..:.:..|:||||:|..:...||::||..|.::.|.:||:::.
  Fly   316 DCDPRSAGMILNDDQLLPLFVVQSVGHIYGMPGLFIAGIFGAGLSSLSSCFNTVSMVFLEDIVRG 380

Mouse   372 RFK-SLSEKSLSWISQGMSVLYGALCIGMAALASLMGALLQAALSIFGMVGGPLLGLFSLGILVP 435
            .|| ..||:..:.:.:...:..|.|...:..|...:..:|....||..:..|...|:|:||:|.|
  Fly   381 FFKMEPSERQSTILIKTCIIFQGILAFLIVFLLQHLRGILSVCNSISSITAGTSFGVFTLGMLFP 445

Mouse   436 FANSIGALTGLLAGFAISLWVGIGAQLYP---PLPERTLPLPLETYGCNITHNGSDWMSTTEMPF 497
            :||:||...|.|:...::.|:..|:|:..   .|....||:.::....|:|.....|:...::
  Fly   446 WANTIGTAVGGLSSVLLAGWISFGSQIAAASGQLKSGMLPVSVKECVGNVTLPEDPWVDQDQV-- 508

Mouse   498 STSAFQIHNAERTPLMDNWYSLSYLYFSTIGTLTTLFVGILISLST 543
                        .||    |.|||.:.|.||.:|.:.||.|:||.|
  Fly   509 ------------FPL----YRLSYHWVSPIGVVTAVVVGALVSLIT 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc5a8	NP_663398.2	SLC5sbd_SMCT1	7..549	CDD:271402	174/560 (31%)
CG31262	NP_001138069.2	SLC5sbd_NIS-SMVT	9..522	CDD:271383	164/536 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836531
Domainoid	1	1.000	46	1.000	Domainoid score	I12033
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.850