DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lrrtm3 and Fili

DIOPT Version :9

Sequence 1:	NP_848793.1	Gene:	Lrrtm3 / 216028	MGIID:	2389177	Length:	582	Species:	Mus musculus
Sequence 2:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster

Alignment Length:	403	Identity:	93/403 - (23%)
Similarity:	162/403 - (40%)	Gaps:	96/403 - (23%)

- Green bases have known domain annotations that are detailed below.

Mouse    20 PTVLLTMLS------SAERGCPKGCRCEG----KMVYCESQKLQEIPSSISAGCLGLSLRYNSLQ 74
            |.:||.:|:      .....||..|:|.|    ....|....|:::|..::.....::|..|.::
  Fly    22 PVLLLLLLTLVILPPETTAFCPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINLTVNRIR 86

Mouse    75 KLKYN-----------------------QFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELIL 116
            .|:::                       .|:..::|..|.|..|.:|::.::||.|:..|..|.|
  Fly    87 TLEFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNLLLLDL 151

Mouse   117 SSNRISYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCR 181
            |.|||..........:.:|..|||:.|.:.||....|:|:..|..|..|:|.|..:|........
  Fly   152 SFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPASNLWHLH 216

Mouse   182 NLELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYMQWNKISVIGQ 246
            .|:.||:..|.:..:..:.|.|:..|..|.::.|..|:|:|:.|..|:||::|.:..|.::::..
  Fly   217 ALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLDLSDNNLTMVPT 281

Mouse   247 TMSWTWSSLQRLDLSGN------------------------------EIEAF------------S 269
            ......|:|..|:|.||                              :..||            :
  Fly   282 QQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDNTHLQTLHLNN 346

Mouse   270 GPS-------VFQCVPNLQRLNLDSNKL--TFIGQEILDSWISLNDISLAGNIWECSRNICSLVN 325
            .|.       :||..||:..:.:.||.|  .:..|..:|   .|..:.|..|..:|:   |||:
  Fly   347 NPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPVD---QLQKLYLGDNPLQCN---CSLL- 404

Mouse   326 WL-----RSFKGL 333
            ||     .:|:|:
  Fly   405 WLWRLVTGNFEGV 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrrtm3	NP_848793.1	LRRNT	33..61	CDD:214470	8/31 (26%)
		LRR 1	63..83		4/42 (10%)
		leucine-rich repeat	66..86	CDD:275380	4/42 (10%)
		LRR_RI	<81..300	CDD:238064	66/269 (25%)
		LRR_8	86..145	CDD:290566	20/58 (34%)
		LRR 2	86..107		7/20 (35%)
		leucine-rich repeat	87..110	CDD:275380	8/22 (36%)
		LRR 3	110..131		7/20 (35%)
		leucine-rich repeat	111..134	CDD:275380	7/22 (32%)
		LRR_8	133..193	CDD:290566	19/59 (32%)
		LRR 4	134..155		8/20 (40%)
		leucine-rich repeat	135..158	CDD:275380	9/22 (41%)
		LRR 5	158..179		6/20 (30%)
		leucine-rich repeat	159..182	CDD:275380	6/22 (27%)
		LRR_8	181..241	CDD:290566	18/59 (31%)
		LRR 6	182..203		5/20 (25%)
		leucine-rich repeat	183..206	CDD:275380	6/22 (27%)
		LRR 7	206..226		6/19 (32%)
		leucine-rich repeat	207..230	CDD:275380	8/22 (36%)
		LRR_8	230..290	CDD:290566	19/108 (18%)
		LRR 8	230..251		4/20 (20%)
		leucine-rich repeat	231..254	CDD:275380	3/22 (14%)
		LRR 9	254..275		8/69 (12%)
		leucine-rich repeat	255..279	CDD:275380	10/72 (14%)
		LRR 10	279..300		5/22 (23%)
		leucine-rich repeat	280..300	CDD:275380	4/21 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	378..410
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	3/21 (14%)
		leucine-rich repeat	98..121	CDD:275380	1/22 (5%)
		LRR_8	120..180	CDD:404697	20/59 (34%)
		leucine-rich repeat	122..145	CDD:275380	8/22 (36%)
		leucine-rich repeat	146..169	CDD:275380	7/22 (32%)
		LRR	<161..>354	CDD:227223	42/192 (22%)
		leucine-rich repeat	170..193	CDD:275380	9/22 (41%)
		leucine-rich repeat	194..217	CDD:275380	6/22 (27%)
		leucine-rich repeat	218..265	CDD:275380	14/46 (30%)
		leucine-rich repeat	266..289	CDD:275380	3/22 (14%)
		leucine-rich repeat	290..313	CDD:275380	5/22 (23%)
		leucine-rich repeat	314..338	CDD:275380	2/23 (9%)
		LRR_8	337..397	CDD:404697	13/62 (21%)
		leucine-rich repeat	339..360	CDD:275380	2/20 (10%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100