Protein Alignment F11 and CG8172

DIOPT Version :10

• Sequence 1: XP_005262878.1
• Gene: F11 / 2160
• HGNCID: 3529
• Length: 626
• Species: Homo sapiens
• Sequence 2: NP_001097235.2
• Gene: CG8172 / 35905
• FlyBaseID: FBgn0033362
• Length: 561
• Species: Drosophila melanogaster
• Alignment Length: 572
• Identity: 153/572 - (26%)
• Similarity: 238/572 - (41%)
• Gaps: 111/572 - (19%)

Human    79 KDSVTETLPR-VNRTAAISGYSFKQCSHQISAC---NKDIYVDLDMKGINYNSSVAK--SAQECQ 137
            ::||.|.|.| :.::....|:.| :|...||..   .|.:  ||...|:.::..|.|  .|:|..
  Fly    61 ENSVMEMLSRMIPQSCRFRGHKF-ECGLSISCVLGGGKPL--DLCSGGMIWSCCVDKDLDAEESP 122

Human   138 -----ERCTDDVHCH-----FFTYATRQFPSLEHRNICLLKHTQTGTPTRITKLDKVVSGFSLKS 192
                 ...:|.:|.|     ..|.|.:....|.|       |:..|          :.:..|..|
  Fly   123 HAAPVNNTSDIIHLHDIYPDLSTNANKPQHHLHH-------HSGNG----------LSAAPSTSS 170

Human   193 CALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFFTFFSQEWPKESQRNLCLL 257
            .|.|:   .|..:|::.:.                   |..|     |.:|...|         .
  Fly   171 TASSS---ARPAYPSSYYG-------------------TKRP-----THYSGSNP---------Y 199

Human   258 KTSESGLPSTRIKKSKALSGFSLQSCRH-------SIP-VFCHSSFYHDTDFLGEELDIVAAKSH 314
            |...|...|:|...|   |..||.|..|       ||. :..|...:.|.:.........|...|
  Fly   200 KPGSSAGGSSRPSSS---SSSSLNSWEHETGGHLGSISGITNHLDSFFDAESQAPLDSAGAPPPH 261

Human   315 EACQKLCTNAVRCQFFTYTPAQASCNEGNRGKCYLKLSSNGSPTKILHGRGGISGYTLRLCKMDN 379
            |.    ..||   |.|    |..:..:.|.|:...:..|.||        ||....:.|......
  Fly   262 EP----LPNA---QAF----AVGNVLDLNAGEAADEYQSGGS--------GGYHDASYRPVPGCG 307

Human   380 ECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHL-CGGSIIGNQWILTAAHCFYGVESPKI- 442
            |..|: ..|||||.::..|..||||.|..:....|.| |||::|.|:|::|||||.....:..:
  Fly   308 EVYTR-SNRIVGGHSTGFGSHPWQVALIKSGFLTRKLSCGGALISNRWVITAAHCVASTPNSNMK 371

Human   443 LRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICLPSKGD 507
            :|:....:...|.:.:...:|::...:|..|..|:...|:||::|:..|.|.....|:|||....
  Fly   372 IRLGEWDVRGQEERLNHEEYGIERKEVHPHYNPADFVNDVALIRLDRNVVYKQHIIPVCLPPSTT 436

Human   508 RNVIYTDCWVTGWG-YRKLRDKIQNTLQKAKIPLVTNEECQKRYRG----HKITHKMICAGYREG 567
            : :......|.||| .|..:..:.:.||:..:.:::|:.||:.:|.    ..|....:||||::|
  Fly   437 K-LTGKMATVAGWGRTRHGQSTVPSVLQEVDVEVISNDRCQRWFRAAGRREAIHDVFLCAGYKDG 500

Human   568 GKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWI 619
            |:|:|:|||||||:...:....|:|:.|||.||.:...||||||:..:|.||
  Fly   501 GRDSCQGDSGGPLTLTMDGRKTLIGLVSWGIGCGREHLPGVYTNIQRFVPWI 552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
F11	XP_005262878.1	APPLE	20..103	CDD:128519	7/24 (29%)
		APPLE	110..193	CDD:128519	18/97 (19%)
		APPLE	200..283	CDD:128519	15/82 (18%)
		APPLE	291..375	CDD:128519	18/83 (22%)
		Tryp_SPc	389..619	CDD:238113	80/236 (34%)
CG8172	NP_001097235.2	Tryp_SPc	316..555	CDD:238113	82/238 (34%)