DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment F10 and CG11836

DIOPT Version :9

Sequence 1:	NP_000495.1	Gene:	F10 / 2159	HGNCID:	3528	Length:	488	Species:	Homo sapiens
Sequence 2:	NP_001356925.1	Gene:	CG11836 / 43007	FlyBaseID:	FBgn0039272	Length:	333	Species:	Drosophila melanogaster

Alignment Length:	243	Identity:	92/243 - (37%)
Similarity:	143/243 - (58%)	Gaps:	12/243 - (4%)

- Green bases have known domain annotations that are detailed below.

Human   230 NNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRV--GDRN 292
            |...|||||:.....:.||.|.:: .:.:..|||::|::.|:|:||||:.:.::.|:||  ||.:
  Fly    92 NEEIRIVGGKPTGVNQYPWMARIV-YDGKFHCGGSLLTKDYVLSAAHCVKKLRKSKIRVIFGDHD 155

Human   293 TEQEEGGEAVHE-VEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQ 356
            .|.....:|:.. |..||||..|..:||:.|||:|||:.||:|...:.|.|||..::..:    .
  Fly   156 QEITSESQAIQRAVTAVIKHKSFDPDTYNNDIALLRLRKPISFSKIIKPICLPRYNYDPA----G 216

Human   357 KTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLS--SSFIITQNMFCAGYDTKQEDACQGDS 419
            :.|.|.|:|||.|.|...:.:..::||.:....|:..  .|..||.:|.|||..:.  |:|||||
  Fly   217 RIGTVVGWGRTSEGGELPSIVNQVKVPIMSITECRNQRYKSTRITSSMLCAGRPSM--DSCQGDS 279

Human   420 GGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMK 467
            |||.:......||:.||||||.||.|:|..|:|::|:.|:.||..:::
  Fly   280 GGPLLLSNGVKYFIVGIVSWGVGCGREGYPGVYSRVSKFIPWIKSNLE 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
F10	NP_000495.1	GLA	25..85	CDD:214503
		EGF_CA	86..122	CDD:238011
		FXa_inhibition	129..164	CDD:317114
		O-glycosylated at one site	183..203
		Tryp_SPc	235..464	CDD:238113	90/233 (39%)
		O-glycosylated at one site	476..485
CG11836	NP_001356925.1	Tryp_SPc	97..325	CDD:238113	90/234 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H30976
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4142
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.940