DRSC/TRiP Functional Genomics Resources

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Protein Alignment F10 and Sp7

DIOPT Version :10

Sequence 1:NP_000495.1 Gene:F10 / 2159 HGNCID:3528 Length:488 Species:Homo sapiens
Sequence 2:NP_649734.2 Gene:Sp7 / 40918 FlyBaseID:FBgn0037515 Length:391 Species:Drosophila melanogaster


Alignment Length:410 Identity:110/410 - (26%)
Similarity:175/410 - (42%) Gaps:87/410 - (21%)


- Green bases have known domain annotations that are detailed below.


Human    93 SPCQNQGKCKDGLGEYTCTCL-----EGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCA 152
            :|.|.||:|   |..|.|..|     :.:.......|.|....||...       .|..|.|:..
  Fly    33 NPNQKQGQC---LSIYDCQSLLSVIQQSYVSPEDRTFLRNSQCLDGVG-------RQPYVCCTSD 87

Human   153 RGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDL 217
            |.:...:...|..|                  ...||||....|.       .|.|.      :|
  Fly    88 RSFGSQEATSAAPP------------------PTTTSSSSRGQDG-------QAGLG------NL 121

Human   218 LDFNQTQPERGDNNLT-RIVGGQECKDGECPWQALLINEENEG----FCGGTILSEFYILTAAHC 277
            |   .:.|:.|.::.: ::..|.:....|..|.|||...:|.|    .|||::::..|:||||||
  Fly   122 L---PSPPKCGPHSFSNKVYNGNDTAIDEFNWMALLEYVDNRGRRELSCGGSLINNRYVLTAAHC 183

Human   278 LYQAKRFK------VRVGDRNTEQEEGGEAVHE----------VEVVIKHNRF--TKETYDFDIA 324
            :..|...:      ||:|:.:|.::.  :.:.:          :|....|.::  ..:....|||
  Fly   184 VIGAVETEVGHLTTVRLGEYDTSKDV--DCIDDICNQPILQLGIEQATVHPQYDPANKNRIHDIA 246

Human   325 VLRLKTPITFRMNVAPACLPERDWAESTLMTQKTG---IVSGFGRTHEKGRQSTRLKMLEVPYVD 386
            :|||..|:.....:.|.|||    ..||.|...||   :|||:||| ...|:||..:.|::|..|
  Fly   247 LLRLDRPVVLNEYIQPVCLP----LVSTRMAINTGELLVVSGWGRT-TTARKSTIKQRLDLPVND 306

Human   387 RNSC--KLSSSFI-ITQNMFCAGYDTKQEDACQGDSGGPHVTR-FKDTYFVTGIVSWGEGCARKG 447
            .:.|  |.::..| :..:..|.|.:. ..|:|.||||||.:.| |...::..|:||:|..|..:|
  Fly   307 HDYCARKFATRNIHLISSQLCVGGEF-YRDSCDGDSGGPLMRRGFDQAWYQEGVVSFGNRCGLEG 370

Human   448 KYGIYTKVTAFLKWIDRSMK 467
            ..|:||:|..::.||..:::
  Fly   371 WPGVYTRVADYMDWIVETIR 390

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
F10NP_000495.1 GLA 25..85 CDD:214503
EGF_CA 86..122 CDD:238011 9/33 (27%)
FXa_inhibition 129..164 CDD:464251 6/34 (18%)
O-glycosylated at one site 183..203 5/19 (26%)
Tryp_SPc 235..464 CDD:238113 80/257 (31%)
O-glycosylated at one site 476..485
Sp7NP_649734.2 CLIP 31..84 CDD:463440 15/60 (25%)
Tryp_SPc 137..388 CDD:238113 80/258 (31%)
Blue background indicates that the domain is not in the aligned region.

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