DRSC/TRiP Functional Genomics Resources

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Protein Alignment F10 and Corin

DIOPT Version :10

Sequence 1:NP_000495.1 Gene:F10 / 2159 HGNCID:3528 Length:488 Species:Homo sapiens
Sequence 2:NP_610297.2 Gene:Corin / 35691 FlyBaseID:FBgn0033192 Length:1397 Species:Drosophila melanogaster


Alignment Length:523 Identity:134/523 - (25%)
Similarity:227/523 - (43%) Gaps:124/523 - (23%)


- Green bases have known domain annotations that are detailed below.


Human    59 EETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTC----TCLEGFEGK 119
            |:....:|.|||...:.      :...||.||:.:.|..|        ||.|    .|::..:..
  Fly   890 EDCVGLDEVREVMRAAT------HPKCDGFQCDQNRCLPQ--------EYVCDGHLDCMDQADEA 940

Human   120 NCE--------------LFTRKLCSLDNG--DCDQFCHEEQNSVVCSCARGYTLADNGKACIPTG 168
            .||              :.|:.:|   :|  || .:..:|:|.:..|...|    |.|...:.. 
  Fly   941 KCERCGPDEIYCGDSQCIGTKHIC---DGIIDC-PYGQDERNCLRLSERNG----DVGTGVLEV- 996

Human   169 PYPCGKQ-----TLERRKRSVAQAT------SSSGEAPDSIT-----------------WKPY-- 203
             |..|::     .::...|:|:.:.      .|:..|...:|                 ||.|  
  Fly   997 -YRIGQRQWMPACVKNWDRAVSPSAVCSILGYSAVNATSVLTQLTHRPLLATVNVSTDIWKMYAK 1060

Human   204 -------DAADLDPTENPFDLLDFNQTQPE-----RGDNNLT-RIVGGQECKDGECPW-QALLIN 254
                   :.|:...||: :.:.|...:..|     ||.:..: ||:||.:...|..|: .|:|..
  Fly  1061 RKSTLMQEFANCKKTED-YPMADLTCSNYECGRVKRGRHKPSRRIIGGTQASPGNWPFLAAILGG 1124

Human   255 EENEGFCGGTILSEFYILTAAHC-----LYQAKRFKVRVG-DRNTEQEEGGEAVHEVEVVIKHNR 313
            .|...:|.|.::|:.::|||:||     :...:.:.:::| .|.......|:.| :|:.||.|.:
  Fly  1125 PEKIFYCAGVLISDQWVLTASHCVGNYSVIDLEDWTIQLGVTRRNSFTYSGQKV-KVKAVIPHPQ 1188

Human   314 FTKE-TYDFDIAVLRLKTPITFRMNVAPACLPE---RDWAESTLMTQKTGIVSGFGRTHEKGRQS 374
            :... .:|.|||:.:|.|.:.|..::.|.|||.   |:....||.|     |.|:|:..:|..:|
  Fly  1189 YNMAIAHDNDIALFQLATRVAFHEHLLPVCLPPPSVRNLHPGTLCT-----VIGWGKREDKDPKS 1248

Human   375 TR---LKMLEVPYVDRNSC-KLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRF---KDTYF 432
            |.   :..::||.:.||.| :...:..:::.|.|||:|...:||||||||||.:..:   |:.:|
  Fly  1249 TYEYIVNEVQVPIITRNQCDEWLDNLTVSEGMVCAGFDDGGKDACQGDSGGPLLCPYPGEKNRWF 1313

Human   433 VTGIVSWGEGCARKGKYGIYTKVTAFLKWI-------DRSMKTRGLPKAKSH--APEV---ITSS 485
            |.||||||..||.....|:|..|..::.||       .|.:|...:.|...|  .|::   |.:.
  Fly  1314 VGGIVSWGIMCAHPRLPGVYANVVQYVPWIQEQIAKHSRPIKEDRVNKYDLHPGGPDILSKIATD 1378

Human   486 PLK 488
            |::
  Fly  1379 PMR 1381

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
F10NP_000495.1 GLA 25..85 CDD:214503 5/25 (20%)
EGF_CA 86..122 CDD:238011 10/39 (26%)
FXa_inhibition 129..164 CDD:464251 10/36 (28%)
O-glycosylated at one site 183..203 6/42 (14%)
Tryp_SPc 235..464 CDD:238113 81/253 (32%)
O-glycosylated at one site 476..485 3/13 (23%)
CorinNP_610297.2 CRD_FZ 778..894 CDD:143549 1/3 (33%)
LDLa 911..942 CDD:238060 10/38 (26%)
LDLa 945..979 CDD:238060 6/37 (16%)
SR 980..>1034 CDD:214555 10/59 (17%)
Tryp_SPc 1104..1346 CDD:238113 81/247 (33%)

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