Protein Alignment F10 and Ser12

DIOPT Version :10

• Sequence 1: NP_000495.1
• Gene: F10 / 2159
• HGNCID: 3528
• Length: 488
• Species: Homo sapiens
• Sequence 2: NP_523456.1
• Gene: Ser12 / 33406
• FlyBaseID: FBgn0011832
• Length: 245
• Species: Drosophila melanogaster
• Alignment Length: 232
• Identity: 87/232 - (37%)
• Similarity: 112/232 - (48%)
• Gaps: 19/232 - (8%)

Human   234 RIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQA--KRFKVRVGDRNTEQE 296
            |||||......|.||||.|:..| :..||..|.|:..|:|||||:.:.  ..:.||||  :..:.
  Fly    23 RIVGGHPVLISEVPWQAALMYSE-KYICGAVIYSDKIIITAAHCVERPFDTLYSVRVG--SVWKN 84

Human   297 EGGEAVHEVEVVIKHNRFTKETYDF-DIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI 360
            .||:.. .|.|:.||..:...|..| ||||:||...:.|...|.|..|     |:|.........
  Fly    85 LGGQHA-RVAVIRKHEDYVSSTILFNDIAVIRLVDTLIFNAEVRPIQL-----ADSAPAAGTEAS 143

Human   361 VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVT 425
            |||:|.......|.|.|....|..:|.|.||.|..: ||:.|.||....|  |:|.||||||.|:
  Fly   144 VSGWGEIGILWLQPTSLLKTSVKILDPNVCKRSYQY-ITKTMICAAALLK--DSCHGDSGGPLVS 205

Human   426 RFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWI 462
            ..:    :.||||:|.|||.....|:|..|.....||
  Fly   206 GGQ----LVGIVSYGIGCANPFFPGVYANVAELKPWI 238

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
F10	NP_000495.1	GLA	25..85	CDD:214503
		EGF_CA	86..122	CDD:238011
		FXa_inhibition	129..164	CDD:464251
		O-glycosylated at one site	183..203
		Tryp_SPc	235..464	CDD:238113	86/231 (37%)
		O-glycosylated at one site	476..485
Ser12	NP_523456.1	Tryp_SPc	23..238	CDD:214473	85/230 (37%)