DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment F2RL2 and AstC-R1

DIOPT Version :9

Sequence 1:	NP_004092.1	Gene:	F2RL2 / 2151	HGNCID:	3539	Length:	374	Species:	Homo sapiens
Sequence 2:	NP_649040.2	Gene:	AstC-R1 / 40020	FlyBaseID:	FBgn0036790	Length:	483	Species:	Drosophila melanogaster

Alignment Length:	344	Identity:	94/344 - (27%)
Similarity:	154/344 - (44%)	Gaps:	68/344 - (19%)

- Green bases have known domain annotations that are detailed below.

Human    59 WTGATITVKIKCPEES------ASHLHVKNATMGYLTSSLSTKLIPAIYLLVFVVGVPANAVTLW 117
            |...:.|::   ||||      .::.|. .||    .:|.:......:|..|.::|:..|.:.::
  Fly    44 WISGSSTIQ---PEESLYGTDLPTYQHC-IAT----RNSFADLFTVVLYGFVCIIGLFGNTLVIY 100

Human   118 -MLFFRTRSICTTVFYTNLAIADFLFCVTLPFKIAYHLNGNNWVFGEVLCRATTVIFYGNMYCSI 181
             :|.|......|.::..|||:||..|.:.:|| :.|.:...:|.|||.:|:|..|......:.|.
  Fly   101 VVLRFSKMQTVTNIYILNLAVADECFLIGIPF-LLYTMRICSWRFGEFMCKAYMVSTSITSFTSS 164

Human   182 LLLACISINRYLAIVHPFT---YRGLPKHTYALVTCGLVWATVFLYMLPFFI----LKQE----- 234
            :.|..:|.:||:|:.||.:   ||.|  | .|.|...:.|:|..:.|||..:    ::||
  Fly   165 IFLLIMSADRYIAVCHPISSPRYRTL--H-IAKVVSAIAWSTSAVLMLPVILYASTVEQEDGINY 226

Human   235 -YYLVQPDITTCHDVHNTCESSSPFQLYYFISLAFFGFLIPFVLIIYCYAAIIRTLNAYD----- 293
             ..::.||....|       |.:.|.||.|    |.||..|...|:..|..:||.|.:..
  Fly   227 SCNIMWPDAYKKH-------SGTTFILYTF----FLGFATPLCFILSFYYLVIRKLRSVGPKPGT 280

Human   294 --------HRWLWYVKASLLILVIFTICFAP---SNIILIIHHANYYYNNTDGLYFIYLIALCLG 347
                    ||.:  .:..|.::.::.:|:.|   |.:.||  |:|....:...|..  ||.|.||
  Fly   281 KSKEKRRAHRKV--TRLVLTVISVYILCWLPHWISQVALI--HSNPAQRDLSRLEI--LIFLLLG 339

Human   348 SL---NSCLDPFLYFLMSK 363
            :|   ||.::|.||..:|:
  Fly   340 ALVYSNSAVNPILYAFLSE 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
F2RL2	NP_004092.1	7tmA_PAR3	95..368	CDD:320493	84/302 (28%)
		TM helix 1	95..122	CDD:320493	5/27 (19%)
		TM helix 2	128..153	CDD:320493	9/24 (38%)
		TM helix 3	166..196	CDD:320493	9/29 (31%)
		TM helix 4	208..230	CDD:320493	7/21 (33%)
		TM helix 5	259..288	CDD:320493	10/28 (36%)
		TM helix 6	294..324	CDD:320493	8/32 (25%)
		TM helix 7	337..362	CDD:320493	11/27 (41%)
AstC-R1	NP_649040.2	7tm_4	88..368	CDD:304433	82/292 (28%)
AstC-R1	NP_649040.2	7tm_1	94..353	CDD:278431	78/279 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910